Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06388226Recruiting
Leg heat therapy for heart failure with preserved pumping ability
This study tests if applying heat to your legs can improve symptoms and heart function in people with a type of heart failure where the heart pumps normally but doesn't relax properly. It aims to find a simple, drug-free way to help you feel better.
Indianapolis, IndianaAges 18 years+ - NCT05174351Recruiting
Stopping beta-blockers in heart failure with preserved pumping
This study checks whether safely stopping beta-blocker medicine is possible in some people with heart failure with preserved pumping (EF ≥50%). It may help by testing whether reducing the medication is safe and workable for certain patients.
Farmington, ConnecticutAges 50–80 - NCT05383287Recruiting
Study of heart failure with preserved pumping function
This study looks at the different features and patterns of people with heart failure where the heart’s pumping strength is preserved. It may help doctors better understand your type of heart failure and tailor care.
ManchesterAges 18 years+ - NCT05784753Recruiting
Exercise coaching for adults with heart failure and preserved heart strength
This study tests an exercise-focused program (including coaching/support) for adults with heart failure where the pumping strength is preserved. It may help improve exercise ability and daily function while monitoring safety.
Detroit, MichiganAges 18 years+ - NCT05651919Recruiting
Blood test study to understand diabetic heart weakness
This study measures immune cells from your blood to find markers (biomarkers) that may explain or predict diabetic cardiomyopathy, a type of heart condition linked to diabetes. You may benefit mainly by being closely monitored and contributing to research that could improve future diagnosis or risk tracking.
BronAges 40–85 - NCT05525663Recruiting
Rehab for older adults after heart failure with strong pumping
This trial studies whether a physical rehabilitation program helps older adults recover and function better after a recent hospital stay for heart failure when the heart’s pumping strength is preserved. It may help you regain walking ability and daily independence after your episode.
Winston-Salem, North CarolinaAges 60 years+ - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+ - NCT04237701Recruiting
Tracking heart failure in real time at Yale
This trial looks at how people with heart failure are doing using real-time monitoring across the Yale New Haven Health System. It may help improve care by spotting problems sooner and tracking treatment effects.
New Haven, ConnecticutAges 18 years+ - NCT06820099RecruitingPhase 2
A drug for heart failure with obesity
This trial tests an oral drug called HRS-7535 for people with a certain type of heart failure (where the heart pumps normally but doesn't relax properly) and who also have obesity. It aims to see if the drug can improve symptoms and daily function.
Beijing, Beijing MunicipalityAges 18–80 - NCT07250529Recruiting
Comparing two pacemaker pacing methods for heart block
This study compares two types of pacemaker pacing methods in people with heart block and normal heart pumping function. It looks at how often short bursts of fast heart rhythm occur in the upper heart chambers, which may help improve long-term heart health.
PátraiAges 18 years+ - NCT07878325Recruiting
Specialized heart and diabetes clinic for people with type 2 diabetes
This trial tests a specialized clinic that combines diabetes and heart care for people with type 2 diabetes who also have heart or blood vessel problems. The clinic will also check for unrecognized heart failure to improve overall health.
SvendborgAges 18 years+ - NCT07575672RecruitingPhase 3
Finerenone after heart valve replacement
This study tests if the drug finerenone helps people with heart failure who had a heart valve replacement (TAVI) for severe aortic stenosis. The goal is to see if it improves heart function and outcomes.
Bengbu, AnhuiAges 65 years+ - NCT07830758RecruitingPhase 1
Resmetirom for fatty liver disease with heart failure
This trial tests a drug called resmetirom for people who have both a type of fatty liver disease (MASH) and a type of heart failure (HFpEF). It aims to see if the drug can help both conditions. You may be able to join if you have both conditions and meet certain health criteria.
Peoria, ArizonaAges 18 years+ - NCT07835828Recruiting
Optimised heart and kidney protection for chronic kidney disease and heart disease
This study tests a new approach to protect the heart and kidneys in people with both chronic kidney disease and heart or blood vessel problems. By optimising treatment, researchers hope to reduce the risk of further kidney or heart damage.
SvendborgAges 18 years+ - NCT05490901Recruiting
Test exercise heart pressure measurements with an ultrasound
This study looks at how well two heart tests taken during exercise—direct heart pressure measurement and an ultrasound—can explain shortness of breath with activity. It may help doctors better diagnose what’s causing your symptoms.
SeoulAges 19 years+ - NCT04343430Recruiting
Hospital study for fluid buildup in heart failure with preserved heart function
This study looks at how well doctors can assess fluid buildup before you leave the hospital if you have a type of heart failure called “preserved ejection fraction.” It may help improve decisions about when and how safely people are discharged.
Vandœuvre-lès-NancyAges 18 years+ - NCT06125925Recruiting
Ablation for AFib in patients with heart failure and preserved ejection fraction
This study tests whether a catheter ablation procedure can help people with atrial fibrillation and a kind of heart failure where the heart pumps normally but doesn't relax properly (HFpEF). It looks at whether the procedure can improve symptoms and heart function.
NanjingAges 18–80 - NCT06208007Recruiting
Predicting heart failure with stiff arteries
This study looks at whether stiffer arteries can help predict a type of heart failure where the heart doesn't relax properly (HFpEF). It's for people who have risk factors like high blood pressure, diabetes, or being older, and who may have early signs of heart trouble.
Göttingen, Lower SaxonyAges 18 years+ - NCT05479669Recruiting
Testing detailed heart scans in people with heart failure symptoms
This study looks at whether doing very detailed heart testing helps understand and guide care for people with heart failure with preserved pumping strength. You may be eligible if you’re an adult with specific symptom levels, recent heart-failure-related visits, and matching scan and blood test results.
GroningenAges 18 years+ - NCT07643818Enrolling by invitationPhase 2
Intravenous iron for heart failure patients with low iron
This study tests whether giving intravenous iron improves symptoms, quality of life, and exercise ability in people with heart failure and low iron levels. Participants will receive iron infusions and be monitored over time to see if their condition improves.
Saint HelierAges 18 years+ - NCT07554638RecruitingPhase 4
Incretin drugs for heart failure with obesity
This trial tests whether incretin-based diabetes medications (like GLP-1 drugs) can help people with a specific type of heart failure called HFpEF that is linked to obesity. The goal is to see if these drugs improve heart function and symptoms.
New York, New YorkAges 40 years+ - NCT06465043Recruiting
Understanding Heart Failure When the Heart Stiffens
This study is for people with a type of heart failure called HFpEF, where the heart pumps normally but doesn't relax well. It aims to better understand heart failure through advanced testing, and it includes people who are newly diagnosed or have had a recent hospitalization.
HelsinkiAges 18–85 - NCT07539766Recruiting
Obesity Surgery Study to Prevent Heart Problems
This study follows people with obesity who are having weight-loss surgery to see if the surgery can help prevent a specific type of heart problem (HFpEF) that sometimes develops in people carrying excess weight. Researchers will track your heart health and metabolism before and after surgery.
Heerlen, LimburgAges 35 years+ - NCT07493915Recruiting
Personalized rehab for veterans with heart failure with preserved ejection fraction
This study tests a tailored exercise program for veterans who have heart failure with preserved ejection fraction (HFpEF). It aims to see if a personalized rehab plan can improve your heart function and quality of life.
Columbia, South CarolinaAges 18 years+
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 125 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.