Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 126 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04592445Recruiting
Nerve ablation for right-sided symptoms in HFpEF heart failure
This trial tests a procedure to “turn off” the right greater splanchnic nerve to improve symptoms in people with HFpEF (heart failure with preserved pumping function). If successful, it may reduce shortness of breath and fluid congestion in daily life.
Birmingham, AlabamaAges 40 years+ - NCT07270536Recruiting
Pacing and heart pressure in HFpEF exercise
This study tests whether a special pacing setting during exercise can help improve heart filling pressures in people with heart failure with preserved ejection fraction (HFpEF) who already have a DDD pacemaker. If you have HFpEF and a pacemaker, you may help researchers find better ways to manage your condition during activity.
HasseltAges 18 years+ - NCT06762964RecruitingPhase 2
Dapagliflozin for Failing Fontan Circulation
This study tests whether a medication called dapagliflozin (a pill for heart failure) can help people with a Fontan circulation who feel short of breath. It aims to improve symptoms and quality of life.
Rochester, MinnesotaAges 18 years+ - NCT06937827Recruiting
Heart failure follow-up clinic after hospital discharge
This program offers phone follow-ups after you leave the hospital to help manage your heart failure. It is for people who had a recent heart failure flare-up but are going straight home without homecare or hospice services.
Brick, New JerseyAges 18–90 - NCT06992089Recruiting
Pacemaker study for heart failure with low heart rate
This trial tests a special pacemaker setting to help your heart beat faster during exercise. It may improve your ability to be active if you have heart failure with preserved ejection fraction (HFpEF) and a low resting heart rate.
ValenciaAges 18 years+ - NCT06977477Recruiting
Managing fluid buildup in heart failure patients
This study tests a new way to manage fluid buildup in patients with a specific type of heart failure (HFpEF) who are in the hospital. It aims to improve how doctors remove excess fluid and help you feel better.
Magdeburg, Saxony-AnhaltAges 18 years+ - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT07015554Enrolling by invitation
IGF1 levels in women with heart failure
This study looks at a hormone called IGF1 in women with a specific type of heart failure (where the heart pumps normally but is stiff). It may help understand if this hormone is linked to the condition.
Shenzhen, GuangdongAges 18 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT06702501Recruiting
Shunt device to treat heart failure with preserved ejection fraction
This trial tests a tiny tube (shunt) placed in the heart to relieve pressure and ease severe shortness of breath. It's for people with a type of heart failure where the heart pumps well but doesn't relax enough.
Rochester, MinnesotaAges 30 years+ - NCT06309550Recruiting
Testing for heart failure with preserved ejection fraction
This trial uses special tests to see if you have a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It's for people who feel short of breath but haven't been diagnosed with this condition yet.
MilanAges Any age - NCT06905405Recruiting
Imaging for early heart failure with stiff heart muscle (HFpEF)
This study uses advanced imaging to find early signs of a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may help if you have shortness of breath and a slightly enlarged heart chamber but don't yet have a clear heart failure diagnosis.
Sheffield, South YorkshireAges 18 years+ - NCT06486649Recruiting
AI tool for diagnosing HFpEF heart failure
This trial is testing a new AI-powered tool to help doctors better diagnose a specific type of heart failure called HFpEF, where the heart pumps normally but doesn't relax properly. It may help you if you have symptoms like shortness of breath or swelling and your heart ultrasound shows normal pumping ability.
Beijing, Beijing MunicipalityAges 18–80 - NCT06208007Recruiting
Predicting heart failure with stiff arteries
This study looks at whether stiffer arteries can help predict a type of heart failure where the heart doesn't relax properly (HFpEF). It's for people who have risk factors like high blood pressure, diabetes, or being older, and who may have early signs of heart trouble.
Göttingen, Lower SaxonyAges 18 years+ - NCT07251361Enrolling by invitation
Exercise program for heart failure with preserved ejection fraction
This study tests whether a special exercise program that combines different types of training (like aerobic, strength, and balance) can improve heart and muscle function, daily abilities, and quality of life in people with heart failure with preserved ejection fraction (HFpEF). You may benefit if your heart failure is stable and you are able to exercise safely.
Pamplona, NavarreAges 18 years+ - NCT07083011RecruitingPhase 2
PET scan study for heart failure and cardiac sarcoidosis
This study uses a special PET scan (68Ga-FAPI) to look at inflammation in the heart. It may help researchers understand heart failure and cardiac sarcoidosis better.
Rochester, MinnesotaAges 18 years+ - NCT07057323Enrolling by invitation
Coronary sinus reducer for heart failure with preserved pumping function
This trial tests a device placed in a heart vein to improve symptoms in people whose heart pumps normally but still causes shortness of breath and fatigue. The device may help relieve pressure in the heart and improve daily life.
Rochester, MinnesotaAges 18 years+ - NCT06979362RecruitingPhase 2
Study of CDR132L for heart failure with preserved pumping function
This trial tests if CDR132L can improve heart structure and function in people with a type of heart failure where the heart pumps normally but is stiff and thickened. It may help if you have heart failure with preserved ejection fraction and a thickened heart muscle.
Birmingham, AlabamaAges 40–84 - NCT06678841Recruiting
Pacing therapy for heart failure with preserved pumping ability
This study tests a new pacing approach for people with a specific type of heart failure (HFpEF) to see if it can improve symptoms and quality of life. It involves a pacemaker-like device that adjusts heart rate based on your needs.
Phoenix, ArizonaAges 40 years+ - NCT04587648Recruiting
Treating cardiac amyloidosis in heart failure with preserved ejection
This trial studies people with heart failure with preserved ejection fraction (HFpEF) and cardiac amyloidosis (an abnormal protein buildup in the heart). It may help researchers understand better treatment for symptoms and heart function in this group.
TaipeiAges 60 years+ - NCT05057806RecruitingEarly Phase 1
Testing how ketones may affect heart benefits in type 2 diabetes
This early study looks at people with type 2 diabetes and certain types of heart failure to see whether changes in “ketones” relate to heart benefits. It may help researchers understand who could benefit most from treatment-related metabolism changes.
San Antonio, TexasAges 18–80 - NCT05479669Recruiting
Testing detailed heart scans in people with heart failure symptoms
This study looks at whether doing very detailed heart testing helps understand and guide care for people with heart failure with preserved pumping strength. You may be eligible if you’re an adult with specific symptom levels, recent heart-failure-related visits, and matching scan and blood test results.
GroningenAges 18 years+ - NCT05723679Recruiting
Breathing-targeted program to improve function in HFpEF
This trial studies a breathing-focused treatment to help people with HFpEF (a type of heart failure) feel and function better. It may help improve daily activity by addressing breathing limits that commonly come with this condition.
Dallas, TexasAges 55–90
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 126 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.