Clinical trials
Preserved Ejection Fraction clinical trials
Below are recruiting preserved ejection fraction clinical trials, each written for real people, not researchers. We’re tracking 125 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07492524Recruiting
Village doctor telehealth program for heart failure with atrial fibrillation
This trial tests a program where village doctors use telehealth to support patients who have both atrial fibrillation (an irregular heartbeat) and heart failure (when the heart doesn't pump well). It aims to improve their health and quality of life.
Yancheng, DongtaiAges 65–80 - NCT07413198Recruiting
Combined home and clinic exercise coaching for heart failure
This trial tests a program that combines home-based and clinic-based exercise coaching to help people with heart failure get more active. It aims to improve health and quality of life.
Winston-Salem, North CarolinaAges 55 years+ - NCT07416279Recruiting
Can tiny bubbles replace catheters for heart pressure checks?
This trial tests if tiny ultrasound contrast bubbles can measure heart pressure, possibly replacing the need for catheter tubes. If you're already getting a heart catheterization, you may be able to join.
LondonAges 21–81 - NCT07385417Recruiting
Early AF treatment for heart failure with preserved pumping function
This study tests using a new electrical pulse treatment for atrial fibrillation (AF) early on, in people who also have a type of heart failure where the heart pumps normally but is stiff. The goal is to see if this treatment helps manage both conditions better.
Frankfurt am MainAges 18–80 - NCT07365501Enrolling by invitation
Blood pressure cuff therapy for heart failure patients
This trial tests if a simple, non-invasive blood pressure cuff procedure can improve blood vessel health in people with possible heart failure. It is an early, single-session study to see how the body responds.
Cuenca, CuencaAges 18 years+ - NCT07324772Recruiting
Exercise program to improve symptoms in atrial fibrillation and heart failure
This study tests if starting a supervised exercise program can help older adults with both atrial fibrillation and a type of heart failure called HFpEF feel better and have a better quality of life. You'll be asked to join exercise sessions and have regular check-ins to see how you're doing.
Chicago, IllinoisAges 60–99 - NCT07270536Recruiting
Pacing and heart pressure in HFpEF exercise
This study tests whether a special pacing setting during exercise can help improve heart filling pressures in people with heart failure with preserved ejection fraction (HFpEF) who already have a DDD pacemaker. If you have HFpEF and a pacemaker, you may help researchers find better ways to manage your condition during activity.
HasseltAges 18 years+ - NCT07251361Enrolling by invitation
Exercise program for heart failure with preserved ejection fraction
This study tests whether a special exercise program that combines different types of training (like aerobic, strength, and balance) can improve heart and muscle function, daily abilities, and quality of life in people with heart failure with preserved ejection fraction (HFpEF). You may benefit if your heart failure is stable and you are able to exercise safely.
Pamplona, NavarreAges 18 years+ - NCT06065124Recruiting
Study on weight loss surgery for heart failure with irregular heartbeat
This trial tests if weight loss surgery can help people with heart failure and atrial fibrillation (an irregular heartbeat) improve their heart condition. You may join if you are between 45 and 70, have a BMI of 32 to 40, and have mild to moderate heart failure with preserved pumping function.
Arnhem, GelderlandAges 45–70 - NCT07237451Recruiting
Heart and kidney study of SGLT2 inhibitors
This study looks at whether a type of diabetes medicine called SGLT2 inhibitors (also known as flozins) can help protect the heart and kidneys in people with both heart failure with preserved pumping function and moderate chronic kidney disease, with or without diabetes.
IașiAges 18 years+ - NCT07223242RecruitingPhase 2/Phase 3
Tailored exercise training for heart failure with preserved pumping strength
This trial tests a personalized exercise program to help people with a type of heart failure called HFpEF. You may qualify if your heart still pumps well but you have trouble being active, and you are willing to use a phone app and exercise regularly.
Dallas, TexasAges 18 years+ - NCT07215715Recruiting
Heart ultrasound study for older adults with heart failure
This study uses a special ultrasound to measure heart stiffness in people 60 and older who have heart failure with preserved or mildly reduced pumping function, with or without a condition called ATTR amyloidosis (a protein buildup in the heart). It also includes healthy controls.
Boston, MassachusettsAges 60 years+ - NCT07202000RecruitingPhase 2
Exercise and a drug to reduce inflammation for heart failure with preserved ejection fraction
This trial tests whether combining exercise with a medication that blocks a protein called activin can reduce inflammation, improve heart function, and help with thinking in people with heart failure with preserved ejection fraction (HFpEF).
Boston, MassachusettsAges 40 years+ - NCT07185100Recruiting
Finding early heart failure in at-risk adults across Germany
This study uses heart MRI scans to find unrecognized heart failure in people who have risk factors like diabetes, kidney disease, high blood pressure, or obesity but haven't been diagnosed with heart failure yet. If you join, you will help researchers learn how common hidden heart failure is and take an important step for your own heart health.
BerlinAges 40–69 - NCT07147114RecruitingPhase 4
Combined macitentan and dapagliflozin for heart failure with lung high blood pressure
This trial tests whether adding two medications—macitentan and dapagliflozin—together is safe and effective for people with heart failure and a certain type of high blood pressure in the lungs. It might help improve your symptoms and daily function.
BusanAges 19 years+ - NCT07093528Recruiting
CS Reducer study for heart failure with preserved pumping function
This trial is testing a device called CS Reducer to see if it can help people with a certain type of heart failure (HFpEF) and a problem with small blood vessels in the heart (CMD). The device may improve blood flow and reduce symptoms.
Rochester, MinnesotaAges 18 years+ - NCT07077811Enrolling by invitation
Pulsed field ablation for heart failure with preserved pumping strength
This trial tests a new procedure called pulsed field ablation for people who have both persistent atrial fibrillation and a type of heart failure (HFpEF). It aims to see if this ablation safely helps control the heart rhythm.
Nantong, JiangsuAges 18–80 - NCT07083011RecruitingPhase 2
PET scan study for heart failure and cardiac sarcoidosis
This study uses a special PET scan (68Ga-FAPI) to look at inflammation in the heart. It may help researchers understand heart failure and cardiac sarcoidosis better.
Rochester, MinnesotaAges 18 years+ - NCT06977477Recruiting
Managing fluid buildup in heart failure patients
This study tests a new way to manage fluid buildup in patients with a specific type of heart failure (HFpEF) who are in the hospital. It aims to improve how doctors remove excess fluid and help you feel better.
Magdeburg, Saxony-AnhaltAges 18 years+ - NCT07057323Enrolling by invitation
Coronary sinus reducer for heart failure with preserved pumping function
This trial tests a device placed in a heart vein to improve symptoms in people whose heart pumps normally but still causes shortness of breath and fatigue. The device may help relieve pressure in the heart and improve daily life.
Rochester, MinnesotaAges 18 years+ - NCT07052539Recruiting
Kidney disease in heart failure with obesity
This study looks at how kidney disease relates to a type of heart failure (called HFpEF) that often happens in people with obesity. It will help doctors understand this connection better.
Jackson, MississippiAges 18–75 - NCT07015554Enrolling by invitation
IGF1 levels in women with heart failure
This study looks at a hormone called IGF1 in women with a specific type of heart failure (where the heart pumps normally but is stiff). It may help understand if this hormone is linked to the condition.
Shenzhen, GuangdongAges 18 years+ - NCT06992089Recruiting
Pacemaker study for heart failure with low heart rate
This trial tests a special pacemaker setting to help your heart beat faster during exercise. It may improve your ability to be active if you have heart failure with preserved ejection fraction (HFpEF) and a low resting heart rate.
ValenciaAges 18 years+ - NCT06979362RecruitingPhase 2
Testing a new medicine for heart failure with thickened heart muscle
This study tests an experimental medicine, CDR132L, to see if it can improve heart structure and function in people with a type of heart failure where the heart muscle is thickened. If you have heart failure with normal pumping function and thickened heart walls, this trial may offer access to a new potential treatment.
Birmingham, AlabamaAges 40–84
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Common questions
- Are there clinical trials for preserved ejection fraction?
- Yes. Clin2 currently lists 125 recruiting preserved ejection fraction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a preserved ejection fraction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a preserved ejection fraction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Mildly Reduced Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Normal Ejection Fraction
- Chronic Heart Failure With Reduced Ejection Fraction
- Preserved Ratio Impaired Spirometry (PRISM)
- Preserved Ratio Impaired Spirometry
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.