Clinical trials
Proton Therapy clinical trials
Below are recruiting proton therapy clinical trials, each written for real people, not researchers. We’re tracking 110 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04648462Recruiting
Proton therapy planning for certain brain tumors
This study builds and tests how proton therapy planning could better protect the brain compared with standard radiation (photon therapy) for adults with certain brain tumors. It may help reduce radiation to sensitive areas like the hippocampus, with the goal of better long-term brain function.
Maastricht, LimburgAges 18 years+ - NCT04934293Recruiting
Virtual reality support during proton radiation for children
This trial tests whether virtual reality (VR) can be used safely and comfortably for children receiving proton radiation. It aims to improve the experience of treatment by using a VR helmet during radiotherapy sessions.
NiceAges 7–18 - NCT05860361Recruiting
Registry to collect proton therapy data for cancer patients
This study collects high-quality information about people who are planning to receive proton therapy for cancer or other tumors. It does not change your treatment; it helps researchers improve proton therapy for future patients.
MilanAges 18 years+ - NCT05861245Recruiting
Proton radiation in 5 or 25 treatments for skull-base tumors
This trial tests a radiation plan using protons given in either 5 or 25 sessions for chordoma or chondrosarcoma at the skull base. The goal is to shrink or control the tumor while protecting nearby critical nerves and brain structures.
Madrid, MadridAges 18 years+ - NCT05917301Recruiting
Pre-surgery proton radiation for soft tissue sarcoma
This trial studies a shorter-course proton radiation plan given before surgery for certain soft tissue sarcomas. The goal is to treat the tumor locally while helping surgery be safer or more effective.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06029218Recruiting
Comparing one vs two proton beams for bone and spine tumors
This trial is testing whether using only one proton beam per day is as safe and effective as using two beams for treating certain bone and spine tumors. It may help reduce treatment time and side effects.
NiceAges 18 years+ - NCT06036706Recruiting
Radiation types and thinking skills for skull base meningioma
This study compares different radiation methods for treating a slow-growing, non-cancerous brain tumor at the base of the skull. It aims to see which approach best protects memory and thinking abilities.
CaenAges 20–65 - NCT06183268Recruiting
Proton therapy for head and neck cancer skin side effects
This study looks at how proton therapy affects skin in people with head and neck cancer. It aims to better understand and manage skin reactions during treatment.
Knoxville, TennesseeAges 18 years+ - NCT06484491Recruiting
Higher-dose proton therapy for stage III lung cancer
This trial tests whether giving a higher dose of a special, precise form of radiation (proton therapy) to the main tumor can improve outcomes for people with stage III lung cancer who are already scheduled for chemoradiation and immunotherapy. It may help by targeting the tumor more effectively while protecting nearby organs.
GroningenAges 18 years+ - NCT06591819RecruitingPhase 2
Shorter pelvic radiation with HDR boost for prostate cancer
This trial tests a shorter course of radiation therapy (hypofractionated whole-pelvis radiation) combined with a high-dose-rate (HDR) brachytherapy boost for men with high-risk or unfavorable intermediate-risk prostate cancer. The goal is to see if this approach controls cancer while possibly reducing side effects.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07317245Recruiting
Humanitas Proton Therapy Study for Solid Tumors
This study collects information from people with solid tumors who are getting proton therapy at Humanitas Hospital in Italy. It helps doctors learn more about how well proton therapy works and who benefits most.
Rozzano, MichiganAges 18 years+ - NCT00991094Recruiting
Study follow-up after proton radiation treatment
This study collects information about both short-term and long-term side effects in people who receive proton radiation. It may help doctors better understand what happens to normal tissues over time and improve follow-up care.
Houston, TexasAges 18 years+ - NCT02070328Recruiting
Proton therapy patient registry for outcomes and long-term follow-up
This study keeps a secure record of people receiving proton therapy to track outcomes over time. It may help researchers understand how proton therapy works in real life and improve future care.
Jacksonville, FloridaAges Any age - NCT06677879RecruitingPhase 2
Proton vs photon radiation for left-sided breast cancer
This study is comparing two types of radiation therapy—proton therapy and standard photon therapy—for people with left-sided breast cancer who need radiation after surgery. The goal is to find out which method best protects the heart while effectively treating the cancer.
ShanghaiAges 18–80 - NCT07580300RecruitingPhase 3
Proton vs. Standard Radiation for Head and Neck Cancer
This trial compares two types of radiation therapy for head and neck cancer: proton therapy (a newer, more targeted approach) versus standard photon therapy (the current common treatment). The goal is to see if protons reduce side effects while treating the cancer just as well.
BergenAges 40–90 - NCT04525989Recruiting
Short-course proton vs photon radiation before rectal surgery
This study compares two types of pre-surgery radiation—protons versus standard photons—in people with high-risk rectal cancer. The goal is to shrink and control the tumor while safely getting you ready for surgery, and to see which approach works better.
Stockholm, SolnaAges 18 years+ - NCT06831461Recruiting
Proton vs photon radiation for brain tumors
This study compares two types of radiation therapy for adults with primary brain tumors that have a good outlook (expected survival longer than 5 years). You will receive either standard photon radiation or the more targeted proton radiation, to see if one works better or causes fewer side effects.
MumbaiAges 18–70 - NCT04656041RecruitingPhase 2
Test chemo with radiation for gastroesophageal cancer
This Phase 2 study tests a combination of chemotherapy (5-FU/leucovorin plus irinotecan and oxaliplatin) together with radiation for certain types of esophagus/stomach-junction cancer. It may help shrink tumors and control cancer that is locally advanced but not spread to distant organs.
Boston, MassachusettsAges 18 years+ - NCT04732065RecruitingPhase 1
ONC206 for certain brain tumors in children and young adults
This Phase 1 study tests ONC206, a new targeted medicine, for diffuse midline gliomas (DMG) with a specific gene change (H3K27 altered) and for some other recurrent brain/spinal cord cancers. It is designed to find the right dose and see whether it can control or shrink tumors after initial treatment or when the cancer returns.
San Francisco, CaliforniaAges 2–21 - NCT05191940Recruiting
Radiation for advanced pancreatic cancer you can’t remove by surgery
This trial studies how well radiation therapy works for pancreatic cancer that is locally advanced (near important blood vessels) and cannot be removed with surgery. It may help shrink or control the cancer when surgery isn’t an option.
Wiener Neustadt, Lower AustriaAges 18 years+ - NCT04466189Enrolling by invitation
Pancreatic cancer patients receiving proton beam treatment
This study follows people with pancreatic cancer who are planning to receive proton beam therapy. It’s meant to learn about their care and outcomes after this treatment, and you would join by agreeing to participate.
Goyang-si, Gyeonggi-doAges 19 years+ - NCT04462042Recruiting
Proton vs photon radiation for anal canal cancer
This study compares two types of radiation—protons versus photons—for anal canal squamous cell carcinoma. It may help find which option delivers treatment more effectively or with fewer side effects.
GothenburgAges 18 years+ - NCT05190172Recruiting
Proton versus photon radiation for IDH-mutated brain tumors
This trial compares two types of radiation—proton therapy versus photon (standard) therapy—for adults with an IDH-mutated grade 2 or 3 brain tumor. The goal is to see which approach works better and/or causes fewer side effects while treating the tumor.
OsloAges 18–65 - NCT02559752Recruiting
Computer brain testing during proton radiation for childhood tumors
This trial studies how children’s thinking and learning skills change while they receive proton beam radiation for a brain/spinal cord tumor. It uses computer-based cognitive tests to better understand brain effects during treatment, which may help future care.
St Louis, MissouriAges 4–21
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Common questions
- Are there clinical trials for proton therapy?
- Yes. Clin2 currently lists 110 recruiting proton therapy studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a proton therapy trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a proton therapy trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.