Clinical trials
Pulmonary Disease clinical trials
Below are recruiting pulmonary disease clinical trials, each written for real people, not researchers. We’re tracking 551 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05061368RecruitingPhase 2
Sildenafil by mouth to improve breathing in COPD
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
Edmonton, AlbertaAges 40–80 - NCT05008081Recruiting
Study for COPD flare-ups given standard rescue medicines
This study looks at people hospitalized for a COPD flare-up (“exacerbation”). It may help improve how flare-ups are treated because participants need to receive the usual rescue medicines like steroids and/or antibiotics and then follow a study plan.
LinzAges 18 years+ - NCT04722835Recruiting
Study lung immune cells in people at risk for COPD
This study looks at different lung immune cell patterns and how they work in smokers who are not yet diagnosed with COPD or asthma. It may help researchers understand why some people are more likely to develop COPD, which could guide future prevention or early treatments.
San Francisco, CaliforniaAges 40–75 - NCT04645602RecruitingPhase 2
Study of pembrolizumab and lenvatinib for lung papillomas
This early-phase trial tests how well pembrolizumab plus lenvatinib can treat respiratory papillomas that have spread to the lungs. It may help people whose lung disease is caused by human papillomavirus (HPV).
New Haven, ConnecticutAges 18 years+ - NCT04676828Recruiting
SPECT-guided radiation to avoid healthy lung in lung cancer
This study tests a special imaging-guided radiation plan that aims to treat lung cancer while reducing radiation to healthy lung tissue. It may help lower lung side effects while keeping the cancer treatment focused on tumor areas.
Sydney, New South WalesAges 18 years+ - NCT04310930RecruitingPhase 2/Phase 3
Find the best treatment plan for a lung infection
This study looks for the best way to treat Mycobacterium abscessus (MABS), a difficult lung infection. You may join a treatment group, or first join an observation group and possibly move into treatment later if you meet the criteria.
Kogarah, New South WalesAges Any age - NCT04179981Recruiting
CPAP treatment effects in older COPD and sleep apnea patients
This study looks at whether using positive airway pressure (often called CPAP) improves health outcomes in older adults who have both COPD and obstructive sleep apnea. It may help find ways to reduce symptoms and complications from “overlap” breathing problems.
Detroit, MichiganAges 60 years+ - NCT03888300Recruiting
Measuring the stickiness of lung mucus in breathing problems
This study measures how thick and stretchy (elastic) lung mucus is. It may help researchers better understand mucus in people with obstructive lung breathing problems.
BrusselsAges 18 years+ - NCT03799354Recruiting
Strength training study for people with COPD
This trial tests whether a maximal strength training program can help people with COPD who are stable. It is looking at people with moderate-to-severe airflow limitation and excludes several other lung and health problems.
Lumezzane, BresciaAges 50–80 - NCT03630211RecruitingPhase 2
Study of stem cell transplant for systemic sclerosis in youth
This Phase 2 study tests whether an “autologous” stem cell transplant—using your own stem cells—can reduce systemic sclerosis disease activity. It is mainly for children, teens, and young adults whose disease did not improve despite standard medicines.
Pittsburgh, PennsylvaniaAges 8–60 - NCT02777879Recruiting
Study gut-like lung bacteria and inflammation in early COPD
This study looks at the lung’s tiny bacteria (microbiome) and inflammation in people with early COPD who have a smoking history. It compares them with smokers who have normal breathing tests, to better understand what may drive COPD early on.
New York, New YorkAges 18–70 - NCT03149341Enrolling by invitation
MRI and computer-heart simulations for heart disease
This study uses MRI scans and computer simulations to learn more about how the heart and blood flow work in people with certain heart or lung conditions. It may help researchers better understand heart problems and improve future care.
Palo Alto, CaliforniaAges Any age - NCT02740868RecruitingPhase 2
Breathing MRI using xenon gas to study lungs
This trial uses a special breathing MRI (you breathe a gas mixture) to measure how well your lungs work. It studies healthy kids and people with lung conditions like cystic fibrosis or asthma, and it may help researchers better understand lung function and flare-ups.
Toronto, OntarioAges 8 years+ - NCT00307281Recruiting
Emphysema and COPD patient registry with sample storage
This study enrolls people who have emphysema/COPD into a research registry and collects health information and biological samples. It may help researchers understand the disease better and improve future treatments.
Pittsburgh, PennsylvaniaAges 21 years+ - NCT07097961Recruiting
Rehab program for kids with lung damage after TB
This study tests a rehab program for children aged 6-17 who have lung damage from a past tuberculosis (TB) infection. The program uses mild-to-moderate physical activity to help improve their breathing and daily life.
KampalaAges 6–17 - NCT00001532Recruiting
How Genes Affect Lung Disease Development
This research study examines how genetic factors contribute to various lung diseases, including alpha-1 antitrypsin deficiency, cystic fibrosis, and chronic obstructive pulmonary disease. Researchers want to understand why some people develop lung disease and how genetics plays a role, which may help improve treatment in the future.
Bethesda, MarylandAges 2–90 - NCT06855329Recruiting
Studying progressive lung scarring (non-IPF)
This study is for people with a specific type of lung scarring (not IPF) to understand how the disease progresses. Researchers will collect detailed health information, imaging, and blood samples to learn more about the condition.
Aurora, ColoradoAges 18–80 - NCT06668389RecruitingPhase 4
Testing a diabetes medicine for repaired tetralogy of Fallot
This study tests a type of diabetes medicine (SGLT2 inhibitor) to see if it can help people who had surgery for tetralogy of Fallot feel better and have stronger heart and lung function. It may be a good fit if you are an adult with repaired tetralogy of Fallot and do not have certain other health problems.
Hong KongAges 18 years+ - NCT07852403Recruiting
Sleep problems and outcomes in pulmonary arterial hypertension
This study looks at how sleep-disordered breathing (abnormal breathing during sleep) affects the long-term health of people with pulmonary arterial hypertension (PAH), a type of high blood pressure in the lungs. By participating, you will have a sleep study and be followed over time to see how your breathing during sleep relates to your PAH outcomes.
BeijingAges 18 years+ - NCT06090838Recruiting
Balloon angioplasty for blood clots in the lungs after pulmonary embolism
This trial tests whether balloon angioplasty can improve breathing and exercise ability in people who still have symptoms and blood flow problems 3 months or more after a pulmonary embolism. It is for those who have completed a pulmonary rehabilitation program.
Amsterdam, North HollandAges 18–80 - NCT07656259Recruiting
Comparing breathing support methods in the heart ICU
This study compares different ways to support breathing in patients who need a ventilator in the cardiac intensive care unit. It aims to find the best approach for people with certain heart conditions, like cardiogenic shock or heart failure.
Rochester, MinnesotaAges 18 years+ - NCT06815185Recruiting
Counseling help for people with interstitial lung disease
This study tests a counseling program to help people with interstitial lung disease (a group of lung conditions that cause scarring and make breathing harder) with rehabilitation and support. It may help you cope better and stay active.
Bologna, BolognaAges 18 years+ - NCT07320703Recruiting
Diagnosing breathlessness in primary care
This project tests whether a tool called "Breathlessness Diagnostics in a Box" helps doctors find the cause of breathlessness more quickly. If you have unexplained or ongoing trouble breathing, this study may help improve your care.
GroningenAges 18 years+ - NCT04114435Recruiting
Heart and lung testing in extremely premature babies
This study looks at how the hearts and lungs work in babies born very early (before 29 weeks). It may help researchers understand why some babies develop breathing and heart circulation problems and how to measure their recovery.
Montreal, QuebecAges 1 week–5 years
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Common questions
- Are there clinical trials for pulmonary disease?
- Yes. Clin2 currently lists 551 recruiting pulmonary disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a pulmonary disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a pulmonary disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.