Clinical trials
Replacement clinical trials
Below are recruiting replacement clinical trials, each written for real people, not researchers. We’re tracking 507 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07723352Enrolling by invitation
Testing Journavx for Thumb Arthritis Surgery Pain
This trial tests a new pain medicine called Journavx (suzetrigine) for people having thumb arthritis surgery. It aims to see how well the medicine controls pain after the operation.
Philadelphia, PennsylvaniaAges 40–80 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07675213Recruiting
Uterine muscle movements and pregnancy after frozen embryo transfer
This trial explores how natural uterine contractions affect pregnancy success in women using hormone therapy for frozen embryo transfer. It may help doctors understand if uterine activity influences implantation.
Ho Chi Minh CityAges 18–42 - NCT07651462Recruiting
Fasting Before Hip Surgery and Gut Health
This study tests whether fasting for 20 days before hip replacement surgery changes your gut bacteria in ways that might help your recovery. Researchers want to understand if this dietary approach affects how well you heal after the operation.
Berlin, State of BerlinAges 18–75 - NCT07601269RecruitingEarly Phase 1
New Mitral Valve Implant for Heart Valve Disease
This early-stage trial tests a new device called the ReValve System that replaces a damaged mitral valve (the valve that controls blood flow in your heart). The study is for people with a weakened heart who have leaking mitral valves and are experiencing heart failure symptoms.
São Paulo, São PauloAges 18 years+ - NCT07596043Recruiting
Higher protein for intensive care patients with kidney failure
This study compares giving a higher amount of protein to a standard amount in ICU patients with sudden kidney failure who need dialysis. The goal is to see if more protein helps recovery.
Bangkok, BangkokAges 18 years+ - NCT07598539Recruiting
Knee replacement recovery care at UPMC
This study compares different rehabilitation plans after knee replacement surgery to find the best way to help you recover. If you're having knee replacement at a UPMC hospital and plan to use UPMC for your rehab, this trial may be for you.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06357442Recruiting
Comparing progesterone methods for young people on estrogen therapy
This study compares two ways to give progesterone to young people on estrogen replacement therapy to see how they affect the lining of the uterus. It will help find which approach may be safer and more effective for your health.
Aurora, ColoradoAges 12–25 - NCT06722066Recruiting
TAVR and heart valve calcium study
This study looks at how calcium buildup in the aortic valve affects long-term results after a TAVR procedure (a minimally invasive heart valve replacement). It may help doctors understand which patients do better over time.
SeoulAges 19 years+ - NCT07569848Recruiting
Custom ankle replacement for severe bone loss
This study tests a custom-designed ankle replacement device for people with severe ankle bone damage or loss. The device is made specifically for each patient at the Rizzoli Institute in Italy to help restore ankle function and reduce pain.
BolognaAges 35–75 - NCT07556003Recruiting
Physical Therapy After Knee Replacement Surgery
This study tests whether a physical therapy program helps improve walking ability and foot pressure patterns in women who have had knee replacement surgery or have knee problems. The goal is to see if structured rehabilitation helps you walk better and more comfortably.
SakakahAges 40–70 - NCT07548385RecruitingPhase 3
New pain medicine for after knee replacement surgery
This study tests a new medication called suzetrigine to help manage pain after knee replacement surgery. The goal is to see if it reduces pain and discomfort better than current treatments.
New York, New YorkAges 18–85 - NCT07532785Recruiting
Water and Land Exercise Before Knee Replacement Surgery
This trial tests whether a 6-week program combining weekly water-based exercise and three times weekly land-based training can help reduce knee pain and improve strength before total knee replacement surgery. The program aims to help you recover better after your operation.
London, EnglandAges 18 years+ - NCT06493994Recruiting
Looking at Myval valve placed through the armpit
This study collects information on people who have already received a new aortic valve through a small cut in their armpit using the Myval valve. Doctors want to see how well this approach works over time.
Lübeck, Schleswig-HolsteinAges 18 years+ - NCT06688448Recruiting
New biologic aortic valve replacement study
This study is testing a new generation of biologic (tissue) replacement valves for the aortic valve in adults aged 18 to 65. It aims to see how well these newer devices work compared to standard options.
São Paulo, São PauloAges 18–65 - NCT06679816RecruitingPhase 4
Hydrocortisone for hormone replacement in large pituitary tumor surgery
This trial tests hydrocortisone as hormone replacement therapy after surgery for large pituitary tumors. It aims to help patients maintain healthy cortisol levels during recovery.
Beijing, Beijing MunicipalityAges 18–70 - NCT07487818RecruitingPhase 2/Phase 3
Vagus nerve stimulation with nicotine replacement for quitting smoking
This study tests whether adding a gentle nerve stimulation device to nicotine replacement therapy (like patches or gum) can help people quit smoking more effectively. It may be a new option for those who have struggled to quit before.
Rochester, MinnesotaAges 18 years+ - NCT06775197RecruitingPhase 4
Partial meniscus replacement with Spongioflex sponge
This trial tests a sponge-like implant (Spongioflex) to replace part of a torn meniscus in the knee. It may help people with pain on the inner or outer side of the knee who have enough healthy rim left to hold the implant.
Greven, North Rhine-WestphaliaAges 18–60 - NCT06676189Recruiting
Comparing two types of plastic knee implants for replacement
This study compares two different types of plastic knee implants (polyethylene) used in total knee replacement surgery. The goal is to see which one works best for patients with knee arthritis.
Clermont-FerrandAges 18–90 - NCT07469072RecruitingPhase 2
Nafamostat doses for dialysis blood thinning in ICU
This trial is testing different doses of a blood thinner called nafamostat in patients who are in the ICU and need continuous kidney dialysis (CRRT). The goal is to find which dose works best to prevent clots in the dialysis machine without causing bleeding problems.
Guangzhou, GuangdongAges 18–80 - NCT07455292Recruiting
Heart valve study using advanced MRI
This study uses a special type of MRI, called 4D flow MRI, to better understand how severe aortic stenosis (a narrowed heart valve) affects heart function. It may help doctors learn more about different types of this condition and improve future treatment.
San Donato MilaneseAges 18 years+ - NCT06799910Recruiting
Optimizing fluid balance with bioelectrical impedance during dialysis in ICU
This trial tests a method to better manage fluid levels in critically ill patients who are receiving a type of dialysis (CVVH) for kidney failure. It uses a device (bioelectrical impedance) to measure fluid in the body, which may help doctors give the right amount of fluids more safely.
SalouëlAges 18 years+ - NCT07437469Recruiting
Binaural beats for pain and anxiety after surgery
This trial tests if listening to binaural beats (a type of sound therapy) after hip or knee replacement surgery can help reduce pain and anxiety. You would receive the sound therapy through headphones while in the recovery room.
Miami, FloridaAges 18–99 - NCT07431762RecruitingPhase 4
Aspirin vs. Warfarin after bioprosthetic valve surgery
This trial compares aspirin to warfarin in the first six months after receiving a bioprosthetic (tissue) heart valve. It aims to find which treatment better prevents blood clots without causing excessive bleeding.
OsakaAges 19 years+
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Common questions
- Are there clinical trials for replacement?
- Yes. Clin2 currently lists 507 recruiting replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.