Clinical trials
Resistance clinical trials
Below are recruiting resistance clinical trials, each written for real people, not researchers. We’re tracking 1,215 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06396312Recruiting
Predicting lithium response in difficult depression
This study looks at how to predict which people with hard-to-treat depression will benefit from adding lithium to their antidepressant. If you have treatment-resistant depression and are considering lithium, this trial may help find the best treatment for you.
Munich, BavariaAges 18 years+ - NCT06423430Recruiting
Deep brain stimulation for treatment-resistant depression (TRANSCEND)
This trial tests a new brain stimulation treatment (deep brain stimulation, or DBS) for people with hard-to-treat depression. It aims to see if targeting a specific brain area can help when other treatments have failed.
Birmingham, AlabamaAges 22–70 - NCT06425380Recruiting
Resistant potato starch for liver cirrhosis and confusion
This study is testing whether a special type of starch (resistant potato starch) can help people with cirrhosis who have had episodes of confusion from liver problems. It may help by changing the bacteria in your gut, which could reduce the risk of future confusion episodes.
Rochester, MinnesotaAges 18–99 - NCT06426173Recruiting
Strength training for people waiting for a heart transplant
This study tests whether resistance training (strength exercises) can help people waiting for a heart transplant. It is for patients who have been on the transplant list for less than a month and are stable enough to exercise safely.
São Paulo, São PauloAges 18–70 - NCT06439225RecruitingPhase 3
Chemo for prostate cancer with DNA repair changes
This trial tests a combination of two chemotherapy drugs (carboplatin and docetaxel) for men whose prostate cancer has spread and has specific changes in DNA repair genes. It aims to see if this treatment can help when other hormone therapies have stopped working.
Calgary, AlbertaAges 18 years+ - NCT06441006RecruitingPhase 2/Phase 3
Personalized treatment for rifampicin-resistant TB
This trial tests a personalized treatment approach for people with rifampicin-resistant TB that is still sensitive to fluoroquinolones. It aims to find the best combination of medicines based on your specific TB profile.
UlaanbaatarAges 14 years+ - NCT06450327Recruiting
Resistant Hypertension: A Complex Condition Study
This study looks at why some people with hard-to-control high blood pressure (resistant hypertension) may also have other health problems. It aims to better understand the condition and how to help patients like you.
Votuporanga, São PauloAges 18–85 - NCT06451172RecruitingEarly Phase 1
New antibiotic eye drops for drug-resistant eye infections
This trial tests a new type of antibiotic eye drop for people with serious eye infections that don't respond to standard antibiotics. It aims to see if these drops can safely treat the infection and help improve vision.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06470243RecruitingPhase 3
Adding carboplatin to cabazitaxel for advanced prostate cancer
This study tests whether adding a chemotherapy drug called carboplatin to another chemotherapy called cabazitaxel works better than cabazitaxel alone for men with advanced prostate cancer that has spread and no longer responds to hormone therapy. All participants must have already had docetaxel chemotherapy.
Fayetteville, ArkansasAges 18 years+ - NCT06476210RecruitingPhase 4
New drug combo for drug-resistant tuberculosis
This trial tests a three-drug combination (bedaquiline, delamanid, and linezolid) to see if it's safe and works well for people with multi-drug resistant or rifampicin-resistant tuberculosis. It may offer a new treatment option if standard drugs aren't working.
Hefei, AnhuiAges 18 years+ - NCT06478784Recruiting
Strength training for multiple sclerosis: a randomized trial
This study tests whether a strength-training program (like lifting weights or using resistance bands) can help people with multiple sclerosis feel better and move better. It is for people who can walk on their own and have been stable (no recent relapses).
ValladolidAges 18 years+ - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65 - NCT03972657RecruitingPhase 1/Phase 2
Testing a new prostate and kidney cancer drug with immunotherapy
This early trial tests whether REGN5678 (nezastomig) is safe and how well it works, either by itself or with an immunotherapy drug (cemiplimab). It targets adults with metastatic castration-resistant prostate cancer and certain metastatic kidney cancers that have already been treated.
Gilbert, ArizonaAges 18 years+ - NCT07206745Recruiting
Chinese and Western medicine for severe pneumonia from drug-resistant bacteria
This trial tests a combination of traditional Chinese and Western medicine for adults with severe pneumonia caused by bacteria that are resistant to multiple antibiotics. It aims to see if this combined approach can improve treatment outcomes.
Zhengzhou, HenanAges 18–80 - NCT06492720Recruiting
Testing focused ultrasound for drug-resistant epilepsy
This study tests a new device called NaviFUS that uses focused sound waves to gently stimulate a small area of the brain. It is for people whose seizures start in one part of the brain and are not fully controlled by seizure medicines.
TaipeiAges 18–65 - NCT06511544Recruiting
Brain stimulation for treatment-resistant depression with rumination
This study tests whether a specific form of brain stimulation (called rTMS) can help people with treatment-resistant depression by targeting brain circuits linked to rumination (repetitive negative thinking). If you have tried at least one antidepressant without success and do not have other major mental health conditions, this trial may be worth exploring with your doctor.
Indianapolis, IndianaAges 18–70 - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT06512220RecruitingPhase 2
Psilocybin for treatment-resistant depression brain imaging study
This study tests whether a psilocybin-based treatment can help people with depression that has not improved after trying several antidepressants. You will receive the study treatment and have brain scans to see how it affects brain connections.
Toronto, OntarioAges 18–65 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Tucson, ArizonaAges 18–65 - NCT06526299RecruitingPhase 2
Higher dose of targeted radiation for prostate cancer with low PSMA levels
This trial tests a higher dose of a radioactive drug (177Lu-PSMA-617) for men whose prostate cancer has spread and does not produce much of a protein called PSMA on scans. The goal is to see if a stronger dose can work better than the standard dose.
San Francisco, CaliforniaAges 18 years+ - NCT06538454Recruiting
Strength training for high blood pressure in postmenopausal women
This study tests whether different levels of resistance (strength) training can help improve heart health in women with high blood pressure who have gone through menopause. It may help you safely lower your blood pressure.
Ribeirão Preto, São PauloAges 50–65 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT06557720Recruiting
Imaging study for hard-to-control epilepsy
This study looks at how different brain scans (like MRI, PET, and EEG) can help find the exact spot where seizures start in people whose epilepsy hasn't been controlled by medicines. It aims to better understand drug-resistant epilepsy so doctors can plan more accurate treatments.
Xi'anAges 18–65 - NCT06566898Recruiting
Tracking antibiotic resistance in pneumonia patients
This study uses advanced genetic testing to monitor antibiotic-resistant bacteria in people with pneumonia. It aims to understand how resistance develops and improve treatment choices.
Shanghai, Shanghai MunicipalityAges Any age
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Common questions
- Are there clinical trials for resistance?
- Yes. Clin2 currently lists 1,215 recruiting resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.