Clinical trials
Resistance clinical trials
Below are recruiting resistance clinical trials, each written for real people, not researchers. We’re tracking 1,198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03973268RecruitingPhase 1
Ketamine study to understand treatment response in hard-to-treat depression
This early-stage study tests ketamine and looks at what brain changes may explain why it helps people with major depression that hasn’t improved with usual treatments. You may be asked to stay in the hospital and complete detailed interviews, mood rating scales, and brain imaging.
Bethesda, MarylandAges 18–70 - NCT03819101RecruitingPhase 3
Aspirin plus atorvastatin for advanced, treatment-resistant prostate cancer
This trial studies whether daily aspirin and atorvastatin can slow advanced prostate cancer that has continued to grow despite hormone therapy. It may help by reducing cancer growth and inflammation, but you would need to meet several specific safety and medication rules.
OlomoucAges 18 years+ - NCT03868293Recruiting
Low-intensity ultrasound for drug-resistant temporal lobe seizures
This pilot study tests whether low-intensity focused ultrasound can reduce seizures in adults whose temporal lobe epilepsy hasn’t improved with at least two anti-seizure medicines. You may be asked to track seizure timing and undergo brain imaging before and during the study.
Boston, MassachusettsAges 18 years+ - NCT03522064RecruitingPhase 2
HRD-positive advanced prostate cancer trial with androgen therapy and chemo
This Phase 2 study tests whether blocking male hormones (androgen therapy) plus the chemotherapy drug carboplatin can shrink advanced prostate cancer in men with specific DNA repair problems. It is for cases where prostate-specific antigen (PSA) is rising even though testosterone is already kept very low.
Sydney, New South WalesAges 18 years+ - NCT03587701RecruitingPhase 2
Anakinra for steroid-resistant inner ear inflammation
This trial tests an anti-inflammatory drug (anakinra) in people whose inner-ear hearing problems have not improved with steroid treatment. It aims to reduce worsening hearing caused by autoimmune inner ear disease or difficult-to-control Meniere’s disease.
New Hyde Park, New YorkAges 18–75 - NCT03573791Recruiting
Testing markers to predict chemo-radiation response in rectal cancer
This trial studies lab “biomarkers” (measurable cancer features) to predict whether rectal cancer will resist chemo-radiation before surgery. The goal is to help doctors better choose treatments and avoid ineffective therapy.
Wuhan, HubeiAges 18–75 - NCT03320304Recruiting
VNS for long-term depression that hasn’t improved with treatment
This trial studies how well and how efficiently VNS therapy works for people with long-lasting or repeated major depression that hasn’t responded to enough antidepressant treatments. It may help patients who are already receiving depression treatment but are still struggling.
ViennaAges 18 years+ - NCT03308773Enrolling by invitation
Prevention program for people at risk of type 2 diabetes
This trial looks at a personalized prevention approach for people who are at risk of developing type 2 diabetes. It may help by targeting your specific health factors before diabetes starts.
Ages 18–100 - NCT03407833Enrolling by invitation
Study changes in the body after weight, gut, or liver treatment
This study looks at how the body’s insulin-sensitivity (how well your body uses sugar/insulin) and organ function change after certain medical procedures. It may help researchers understand why some people improve after surgery or liver transplant and guide future care.
Nashville, TennesseeAges 18 years+ - NCT03041883Recruiting
Crosslinking to help a KPro eye resist corneal melting
This trial tests a treatment called corneal collagen crosslinking to strengthen the tissue under a KPro type I (an artificial cornea). It may help reduce the risk of corneal melting in people who need a KPro.
Montreal, QuebecAges 18–80 - NCT02880631Recruiting
Barostim therapy for resistant hypertension
This trial is evaluating a device called BAROSTIM NEO, which sends electrical signals to help lower high blood pressure. It is for people who have recently had the device implanted and still have high blood pressure despite taking multiple medications.
BerlinAges Any age - NCT02994433RecruitingPhase 1
Testing nitrous oxide for depression brain circuit activity
This early study tests whether nitrous oxide, aimed at specific brain circuits, can change depression-related brain activity. It is mainly for adults with major depression or treatment-resistant depression, and includes brain imaging during the study.
St Louis, MissouriAges 18–65 - NCT02861781Recruiting
Collecting body tissue samples during bariatric surgery
This study collects small tissue samples during planned weight-loss surgery to better understand metabolism and how insulin works in people with and without type 2 diabetes. You may help researchers by allowing their team to take these samples while you are already having surgery.
MontpellierAges 18–65 - NCT02531880RecruitingPhase 1
MRI test of a brain barrier issue in hard-to-treat epilepsy
This early-phase study uses a special MRI approach to look for signs that the “blood-brain barrier” is breaking down in people with drug-resistant epilepsy. It may help researchers understand what is happening in the brain and guide future treatments, though it is primarily a testing/study study.
Bethesda, MarylandAges 18–60 - NCT02646475RecruitingPhase 1
Study angiotensin medicine to improve metabolism in obesity
This Phase 1 study tests how a medication that affects the body’s angiotensin system (angiotensin-(1-7)) changes metabolism in adults with obesity, insulin resistance, and high blood pressure. It may help researchers understand whether this approach can improve blood sugar/insulin function and related body changes.
Nashville, TennesseeAges 18–60 - NCT02333110Recruiting
Grid radiation therapy for advanced, painful tumors
This trial tests a way of giving palliative radiation using a “grid” to treat advanced tumors that are large, resistant to standard radiation, or already needed more than one palliative radiation session. It may help better control symptoms when a cure is not the goal.
Montreal, QuebecAges 18 years+ - NCT01933620Enrolling by invitation
NIH study of the microbiome using stored body samples
This study looks at the community of microbes in the body (your “microbiome”) using samples like stool, urine, and possibly tissue. It may help researchers understand how these microbes relate to health in hospital patients.
Bethesda, MarylandAges 2–120 - NCT02122562RecruitingPhase 2
Ketamine treatment for depression that hasn’t responded to care
This Phase 2 study tests ketamine for people with major depression that hasn’t improved after at least one antidepressant. It aims to see whether ketamine can reduce depression symptoms during a current depressive episode.
Iowa City, IowaAges 18–55 - NCT01746836RecruitingPhase 2
Ponatinib for CML that didn’t respond to prior pills
This trial studies ponatinib as a second treatment for chronic myeloid leukemia (CML) when it didn’t fully respond or couldn’t be tolerated with at least one prior CML pill. It aims to see whether ponatinib can better control leukemia levels after earlier treatments.
Houston, TexasAges 18 years+ - NCT01580982Recruiting
Analyze tumor genetic changes to understand lung cancer resistance
This study looks at lung cancer tumor tissue to find genetic “on/off” changes and why treatments may stop working. It may help your care team choose better next tests or treatments based on what the tumor is doing.
Aurora, ColoradoAges 18–85 - NCT00001987Recruiting
Understanding genetics of insulin resistance and diabetes
This research study looks at the genes and immune system factors that cause severe insulin resistance—a condition where the body doesn't respond well to insulin. Researchers want to understand why some people develop this problem and study family members and healthy volunteers to learn more.
Bethesda, MarylandAges 6 months–120 years - NCT01143480Recruiting
Testing how the body responds to endotoxin
This study checks how your immune system (your body’s defense system) reacts to a controlled substance that triggers inflammation. It may help researchers understand why some people have stronger or weaker inflammatory responses.
Research Triangle Park, North CarolinaAges 18–100
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Common questions
- Are there clinical trials for resistance?
- Yes. Clin2 currently lists 1,198 recruiting resistance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a resistance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a resistance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.