Clinical trials
Respiratory Failure clinical trials
Below are recruiting respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 198 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07366541Recruiting
Predicting oxygen therapy failure using a monitoring device
This study tests a monitoring device to predict if a patient with low oxygen levels will need a breathing tube within 72 hours. It aims to help doctors decide earlier if a patient needs more intensive support.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07517497Recruiting
Lung Vibration Device for Seniors With Hip Fracture and Breathing Problems
This study tests a special vibration device on the chest to help older adults who have both a hip fracture and acute breathing failure recover better. The device uses gentle vibrations to help clear the lungs and improve breathing.
AstanaAges 60–85 - NCT07211529Recruiting
Nerve block during chest surgery to reduce complications
This trial tests whether a numbing injection near the spine (paravertebral block) given during keyhole chest surgery can lower the risk of problems after surgery. It might help patients recover more comfortably.
Wuhan, HubeiAges 18–80 - NCT05689476Recruiting
Measuring diaphragm breathing signals during ICU ventilation
This study measures electrical activity of the diaphragm and how your breathing system works while you are on a breathing machine in the ICU. It may help doctors better understand breathing during recovery after major lung events.
Padova, ItalyAges 18 years+ - NCT07701096Enrolling by invitation
Home breathing support monitoring for advanced COPD
This study tests a home monitoring system that watches how well noninvasive breathing support (a mask that helps you breathe) works for people with severe COPD. The system sends early warnings to your care team if your breathing patterns change, which may help prevent flare-ups.
BeijingAges 18 years+ - NCT04445285RecruitingPhase 2
Test drops to thin lung mucus in severe COVID-19
This Phase 2 trial tests rhDNase (a medication similar to Pulmozyme) to improve outcomes and reduce the risk of death in people with severe COVID-19 causing breathing failure. It’s meant for adults who need high-flow oxygen or a breathing machine.
Mobile, AlabamaAges 18 years+ - NCT06401083RecruitingPhase 4
Extra caffeine dose before removing breathing tube in preemies
This study tests if giving an extra dose of caffeine (a medicine that helps premature babies breathe) right before removing the breathing tube can make the transition easier. It is for very premature babies who have been on a ventilator for at least two days and are ready for their first try at breathing on their own.
BudapestAges Any age - NCT06425354Recruiting
Can breathing machine energy predict lung inflammation?
This study looks at a new measure called 'mechanical power' (the energy from the breathing machine) to see if it can predict inflammation in the lungs and blood of patients with low oxygen levels. It may help doctors better understand how the breathing machine affects lung damage.
RomaAges 18 years+ - NCT02299921Recruiting
Alcohol and drug effects on immunity in ICU breathing patients
This study looks at how alcohol and other drugs can affect the body’s immune system in people who are very sick in the ICU due to breathing problems. It may help doctors better understand immune changes during critical illness and respiratory failure.
Aurora, ColoradoAges 18–90 - NCT05108896Recruiting
Testing breathing and swallowing recovery after ICU breathing support
This study looks at aspiration (food or liquid going “the wrong way” into the airway) in people who survived a serious ICU breathing problem. It may help doctors better support safe swallowing and breathing recovery after being on a breathing machine.
Stanford, CaliforniaAges 18 years+ - NCT06609577Recruiting
Ultrasound-guided diaphragm pacing for patients on ventilators
This trial tests a personalized pacing device that uses ultrasound to help your diaphragm muscle work better while you are on a breathing machine. It may help you breathe on your own sooner and improve your recovery.
Nantong, JiangsuAges 18–95 - NCT05513508Recruiting
Tested a protective breathing mask in COPD and respiratory failure
This study tests how well a specific breathing mask setup works in people who need noninvasive ventilation (breathing support without a breathing tube), especially during COPD flare-ups or certain kinds of breathing failure. It may help reduce complications related to the mask while supporting breathing for at least a day.
NovaraAges 18 years+ - NCT07613918Recruiting
Brain Blood Flow Monitoring in Critically Ill Children
This study measures how well blood flows to your child's brain while they're in the intensive care unit on a breathing machine. Understanding this flow may help doctors better care for critically ill children.
Madison, WisconsinAges 1 day–17 years - NCT07615010RecruitingPhase 2
agenT-797 Plus Standard Care for Severe Pneumonia With Respiratory Failure
This trial tests whether adding an experimental drug called agenT-797 to standard pneumonia treatment helps patients in the ICU who have severe pneumonia and serious difficulty breathing (acute hypoxemic respiratory failure). The drug is designed to help the immune system fight severe infection.
San Francisco, CaliforniaAges 18 years+ - NCT06699433Recruiting
AI virtual pediatric patient training for primary care doctors
This trial uses artificial intelligence to create virtual standardized pediatric patients. It helps train doctors who work in primary care settings, like community health centers and clinics.
Guiyang, GuizhouAges Any age - NCT07536750Recruiting
Comparing Two Sedation Drugs for ICU Patients on Breathing Support
This study compares two medications (ciprofol and propofol) used to keep ICU patients calm and comfortable while they receive non-invasive breathing support, such as oxygen masks or tubes that help them breathe without a breathing tube in their windpipe. Researchers want to see which drug works better and is safer.
Guangzhou, GuangdongAges 18 years+ - NCT07536984Enrolling by invitation
Personalized Oxygen Levels for Breathing Machine Patients
This study tests whether adjusting oxygen levels on a breathing machine (ventilator) to match each patient's individual needs improves outcomes. Doctors will carefully monitor your oxygen levels and see how different targets affect your recovery.
Nashville, TennesseeAges 18 years+ - NCT07532811Recruiting
How Lungs Distribute Air and Blood in Critically Ill Children
This pilot study uses a special belt around the chest to measure how air and blood are distributed in the lungs of children on breathing machines in the intensive care unit. The goal is to better understand lung function in critically ill children.
Bron, FranceAges Up to 12 years - NCT07518862Recruiting
Using heart rate to guide oxygen therapy settings
This study uses a simple, non-invasive test (heart rate monitoring) to help doctors adjust the flow of oxygen therapy through a nasal cannula. It may help improve how well this breathing support works for you.
Toronto, OntarioAges 18 years+ - NCT07522450Recruiting
Sleep monitoring in critically ill patients on breathing support
This study measures sleep quality in patients hospitalized in intensive care who need help breathing. Researchers will use EEG (brain wave monitoring) to see if tracking sleep helps improve patient care and outcomes.
RouenAges 18 years+ - NCT07502677Recruiting
Can a sleep test detect breathing trouble in ALS?
This study tests a new wearable device called SleepImage to see how well it detects breathing problems during sleep in people with ALS. The goal is to catch early signs of respiratory failure before they become serious, helping doctors decide when to start breathing support.
LondonAges 18 years+ - NCT07503509Recruiting
Study of high PEEP in noninvasive ventilation
This study tests whether using higher pressure settings (PEEP) on a noninvasive breathing mask can help people with low oxygen levels. The doctors will measure the pressure inside your esophagus to guide the treatment.
Chongqing, Chongqing MunicipalityAges 18–100 - NCT07428694Recruiting
Detecting air leaks during breathing support
This trial tests a machine learning tool to detect if air is leaking while using a breathing machine at night. It may help people who use a non-invasive ventilator at home get better care.
OsloAges 18 years+ - NCT06220825Recruiting
Breathing support practices in critically ill children
This trial looks at how doctors manage breathing support for children in the intensive care unit. It may help improve care for kids who need help breathing.
GroningenAges Up to 18 years
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Common questions
- Are there clinical trials for respiratory failure?
- Yes. Clin2 currently lists 198 recruiting respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.