Clinical trials
Respiratory Failure clinical trials
Below are recruiting respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 210 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07428694Recruiting
Detecting air leaks during breathing support
This trial tests a machine learning tool to detect if air is leaking while using a breathing machine at night. It may help people who use a non-invasive ventilator at home get better care.
OsloAges 18 years+ - NCT07007715Recruiting
Finding the best oxygen flow setting after extubation
This trial tests different flow rates for a high-flow nasal cannula (a device that delivers warm, moist oxygen) after a breathing tube is removed. It aims to find the best setting for patients moving from a ventilator to breathing on their own.
TaipeiAges 18 years+ - NCT06939361Enrolling by invitation
Tube size study during emergency breathing tube placement
This trial compares different sizes of breathing tubes used in emergencies to see which works best. It helps doctors choose the right tube for patients who need help breathing.
Birmingham, AlabamaAges 18 years+ - NCT01571986Recruiting
Improving non-invasive breathing support
This study is looking at ways to improve non-invasive ventilation, which is breathing support given without a breathing tube. You may be invited if you’re already receiving this kind of support and you agree to take part.
MilanAges 18–99 - NCT07223762Enrolling by invitation
Comparing two types of laryngoscope blades for intubation
This trial compares two types of laryngoscope blades (the tool used to guide a breathing tube) to see which works better for routine intubations. If you are an adult scheduled for a planned breathing tube placement, you may be able to join.
Los Angeles, CaliforniaAges 18 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Little Rock, ArkansasAges 2 months–17 years - NCT03758508Recruiting
Noninvasive breathing support versus high-flow oxygen for pneumonia
This study compares two ways to help breathing in adults with pneumonia who have low oxygen levels: a noninvasive breathing machine versus high-flow oxygen. It aims to see which option helps patients breathe better and avoid getting worse.
MilanAges 18 years+ - NCT07419438Recruiting
Airway device study for preterm babies needing breathing help
This study tests a supraglottic airway device (a tube that sits above the voice box) versus a face mask for helping premature babies breathe right after birth. It may help doctors choose the best way to support your baby's first breaths.
Philadelphia, PennsylvaniaAges birth–1 day - NCT04273607RecruitingPhase 2/Phase 3
Test an ECMO approach without blood thinners for lung failure
This trial studies whether people on a breathing machine called VV-ECMO can be managed without routine blood thinners, to reduce bleeding risk. It is meant for adults with severe lung failure (ARDS) and checks that it is safe for you to avoid anticoagulation.
Toronto, OntarioAges 18 years+ - NCT04445285RecruitingPhase 2
Test drops to thin lung mucus in severe COVID-19
This Phase 2 trial tests rhDNase (a medication similar to Pulmozyme) to improve outcomes and reduce the risk of death in people with severe COVID-19 causing breathing failure. It’s meant for adults who need high-flow oxygen or a breathing machine.
Mobile, AlabamaAges 18 years+ - NCT04666246Recruiting
Studying breathing effort in people with COVID-19 breathing failure
This study looks at how hard people with COVID-19 are working to breathe when they have serious breathing trouble but are not yet fully on a breathing machine. The results may help doctors better understand breathing support needs and improve care.
ModenaAges 18–80 - NCT04707729Recruiting
Checking when to intubate patients on nasal high-flow oxygen
This study looks at a scoring system (ROX Index) to help decide the best timing to place a breathing tube (intubate) for adults who are struggling to get enough oxygen while using nasal high-flow (NHF). The goal is to see if using this timing approach can improve care for acute lung failure in the ICU.
Chicago, IllinoisAges 18–120 - NCT04772183Recruiting
Testing pulse oximeters against a blood-gas test in ICU
This trial compares how well different fingertip pulse oximeters measure oxygen levels, using an arterial blood test as the reference. It may help improve oxygen monitoring for ICU patients, especially when measurements can be hard or inaccurate.
Montreal, QuebecAges 18 years+ - NCT05011877Recruiting
Study for sleep testing after sudden breathing trouble
This trial studies people who unexpectedly end up in the hospital or emergency room because of a sudden worsening in breathing that leads to too much carbon dioxide. It may help doctors understand whether sleep-related breathing issues contribute and how to better prevent repeat episodes.
Toronto, OntarioAges 18 years+ - NCT05014581RecruitingPhase 3
Testing vasopressors to prevent low blood pressure during intubation
This trial studies whether using blood-pressure support medicines (vasopressors) during breathing tube placement (intubation) can prevent dangerous drops in circulation (“cardiovascular collapse”). It may help patients stay stable during and after intubation, especially in critical illness.
NantesAges 18–90 - NCT05108896Recruiting
Testing breathing and swallowing recovery after ICU breathing support
This study looks at aspiration (food or liquid going “the wrong way” into the airway) in people who survived a serious ICU breathing problem. It may help doctors better support safe swallowing and breathing recovery after being on a breathing machine.
Stanford, CaliforniaAges 18 years+ - NCT05261607Recruiting
Study outcomes for people in the intensive care unit
This study looks at how mortality (whether patients survive) changes over time for people treated in an intensive care unit. It may help hospitals understand what happens to ICU patients and improve care planning.
Getafe, MadridAges Any age - NCT05379673Recruiting
Breathing changes with extra oxygen after surgery
This study looks at whether giving extra oxygen during recovery from general anesthesia changes how you breathe after surgery. You may be offered different oxygen levels around the time you wake up to see what helps your breathing most comfortably.
Stanford, CaliforniaAges 18–70 - NCT05513508Recruiting
Tested a protective breathing mask in COPD and respiratory failure
This study tests how well a specific breathing mask setup works in people who need noninvasive ventilation (breathing support without a breathing tube), especially during COPD flare-ups or certain kinds of breathing failure. It may help reduce complications related to the mask while supporting breathing for at least a day.
NovaraAges 18 years+ - NCT05520762Recruiting
Trial for patients after in-hospital cardiac arrest needing breathing support
This trial studies a hospital treatment for people who have a cardiac arrest while in the hospital and still need help breathing. It may help improve care right after this emergency by testing an airway resuscitation approach.
New York, New YorkAges 18 years+ - NCT05590130Recruiting
Test two oxygen targets using different oxygen monitors
This study compares how much oxygen is needed and how well oxygen levels stay in a safe range after heart surgery in the ICU. It also tests whether using different oxygen monitors affects oxygen flow and oxygenation.
Québec, QuebecAges 18 years+ - NCT05686850Recruiting
Noninvasive breathing support vs high-flow oxygen after ICU extubation
This study compares two breathing supports used after a breathing tube is removed in the ICU: a noninvasive ventilator (mask-based) versus high-flow nasal oxygen. It aims to see which one works better when patients develop breathing trouble soon after extubation.
BrusselsAges 18 years+ - NCT05751863Recruiting
Sedation-first vs usual care in ventilated trauma patients
This study compares how pain medicine and calming medicine are started in critically injured (trauma) adults who are on a breathing machine. It aims to see whether a specific “analgesia-first” approach can improve comfort and support breathing weaning.
Long Beach, CaliforniaAges 18 years+ - NCT06039501Recruiting
The Family Perspectives Project Pilot Trial
This study looks at how to improve communication between families and the care team when a loved one is on a breathing machine in the intensive care unit. It may help families feel more supported and involved in care decisions.
Los Angeles, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for respiratory failure?
- Yes. Clin2 currently lists 210 recruiting respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.