Clinical trials
Chronic Respiratory Failure clinical trials
Below are recruiting chronic respiratory failure clinical trials, each written for real people, not researchers. We’re tracking 93 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03642002Recruiting
Music therapy for adults on breathing machines in the ICU
This trial tests whether music therapy can improve comfort and recovery for adults who need a breathing machine (mechanical ventilation) in the ICU for at least 48 hours. It may help with stress, mood, and other ICU-related symptoms while you are in critical care.
New York, New YorkAges 18 years+ - NCT04236726Recruiting
Quality of life study for people with chronic breathing failure
This study looks at how chronic respiratory failure affects day-to-day quality of life. It enrolls people who use breathing support at home or in care, and may help clinicians understand what support works best for patients’ daily living.
LondonAges 18 years+ - NCT05089695Recruiting
Compare noninvasive breathing supports for breathing failure
This trial compares different ways to help you breathe without a breathing tube: helmet NIV, CPAP, or high-flow nasal oxygen. It aims to see which support works best for people who have sudden (acute) low oxygen levels.
RomeAges 18 years+ - NCT05150483Recruiting
Study of a blood test in new severe breathing failure
This trial looks at how a test might help evaluate adults who come to the emergency room with a brand-new, sudden breathing problem that needs high-flow oxygen. It may help doctors identify what’s going on faster and guide care in the early hours.
Athens, AtticaAges 18 years+ - NCT06357780Recruiting
Comparing two breath-timing methods for breathing masks in adults
This study compares two ways of timing a breathing mask's support to match your own breaths. If you're in the ICU or ER and need help breathing for at least 2 more hours, this trial may test which method works better.
IzmirAges 18 years+ - NCT06374589Recruiting
Closing the loop on oxygen use during high flow therapy
This trial tests a system that automatically adjusts oxygen levels for patients receiving high flow oxygen therapy. The goal is to see if it can keep oxygen levels in a safe range better than usual care.
IstanbulAges 18 years+ - NCT06501118Recruiting
Oxygen levels in ICU patients on breathing machines
This study tests whether giving a little more oxygen to ICU patients on breathing machines leads to better recovery. It compares usual oxygen levels to a more liberal target to see which is safer and more effective.
Aurora, ColoradoAges 18 years+ - NCT06716463Recruiting
Predicting breathing support failure with wearable monitoring
This study tests if a wearable chest monitor can predict when breathing support (like a mask or nasal prongs) might stop working, so doctors can act faster. It is for hospital patients who need help breathing but are not on a breathing tube.
Toronto, OntarioAges 18 years+ - NCT06952816Recruiting
Testing EMILY AI for respiratory failure
This study tests a new AI device (EMILY) that helps monitor breathing problems like acute respiratory failure. You may join if you are in a hospital for respiratory care and meet certain health criteria.
MadridAges 18 years+ - NCT07071935RecruitingPhase 2
Early ventilation study for newly diagnosed ALS
This trial tests whether starting non-invasive ventilation (breathing support) early in ALS helps people breathe easier and live better. If you've been diagnosed with ALS in the last 6 months and haven't used a breathing machine before, you may qualify.
Hershey, PennsylvaniaAges 18 years+ - NCT07451977Recruiting
Oxygen during a 6-minute walk test for lung disease
This trial tests whether adding extra oxygen during a 6-minute walk test helps people with chronic lung disease breathe better. It is for people with COPD or interstitial lung disease who have low oxygen levels, either during exercise or all the time.
Lumezzane, BresciaAges 18 years+ - NCT07521254Recruiting
High-flow oxygen and breathing support for acute respiratory failure
This trial tests whether high-flow oxygen delivered through the nose, combined with non-invasive breathing support (a mask that helps you breathe without a tube down your throat), can help patients with sudden severe breathing problems. The goal is to improve oxygen levels and avoid the need for a breathing tube.
Minya, Minya GovernorateAges 18 years+ - NCT06938217Enrolling by invitation
Low-flow ECMO for adults with severe breathing failure
This study tests whether a gentler, low-blood-flow version of ECMO (a machine that helps oxygenate blood outside the body) is safe and effective for adults with very severe breathing failure. It is for patients who are already on a breathing machine and have very low oxygen levels despite that support.
San Antonio, TexasAges 18–65 - NCT07279831Recruiting
Brain-lung interaction study in acute respiratory failure
This trial looks at how the lung and brain communicate during serious breathing problems. If you are in the ICU with a new breathing issue and need high-flow oxygen therapy, researchers want to study your brain and lung activity together.
ParisAges 18 years+ - NCT07189078Recruiting
Comparing intubation methods for patients with low blood oxygen
This study tests two different ways to place a breathing tube in patients who are in intensive care with very low oxygen levels and need help breathing. The goal is to find which method is safer and works better for patients like you.
AngersAges 18 years+ - NCT05756387Recruiting
Improving nighttime home breathing support for people with COPD
This study tests different ways to improve chronic noninvasive nighttime breathing support at home for people with COPD. It may help make home treatment easier and more effective, using better tools and setup.
GroningenAges Any age - NCT04970888Recruiting
Exercise program to improve thinking and brain blood flow in heart failure
This trial tests whether doing a combined mental (cognitive) and physical exercise program can improve thinking and how well blood flows to the brain in people with chronic heart failure. It may help by strengthening both brain function and physical capacity while your heart condition stays stable.
Montreal, QuebecAges 50 years+ - NCT05675345Recruiting
Negative pressure breathing device for sudden low-oxygen breathing failure
This trial studies a continuous negative external pressure device (a “cuirass” that helps breathing) for people with sudden, severe low oxygen levels. It aims to see whether the device improves breathing and oxygen levels without needing immediate intubation.
New York, New YorkAges 18 years+ - NCT06247397Recruiting
High-flow therapy for long-term oxygen users
This trial tests if adding high-flow oxygen therapy to your usual long-term oxygen therapy can help you breathe better. It is for people with COPD or ILD who use oxygen at home for at least 15 hours a day.
Karlskrona, Blekinge CountyAges 18 years+ - NCT07428694Recruiting
Detecting air leaks during breathing support
This trial tests a machine learning tool to detect if air is leaking while using a breathing machine at night. It may help people who use a non-invasive ventilator at home get better care.
OsloAges 18 years+ - NCT07047092RecruitingPhase 3
CPAP vs. NIV for sleep apnea in COPD after breathing failure
This trial compares two breathing devices (CPAP and NIV) for people with both COPD and sleep apnea who recently needed breathing help in the hospital. The goal is to see which device works better at preventing future breathing emergencies.
ParisAges 18–84 - NCT06690203Enrolling by invitation
Herbal Medicine for Chronic Lung Conditions (NRICM102)
This trial tests an herbal medicine called NRICM102 for people with chronic cough and long-term lung diseases like asthma or COPD. It aims to see if the medicine is safe and helps improve symptoms.
Taichung, No.1650, Taiwan Boulevard Sect. 4Ages 18 years+ - NCT06912360Recruiting
CPAP support for severe breathing failure in Burkina Faso
This trial tests if CPAP, a breathing machine that keeps airways open, helps adults with severe breathing problems and low oxygen levels. It is for people in Burkina Faso who need extra oxygen to breathe well.
Bobo-Dioulasso, HouetAges 18 years+ - NCT06047405Recruiting
Comparing two breathing machine settings for high carbon dioxide failure
This trial tests two different ways of setting a noninvasive breathing machine (BiPAP) to help patients with high carbon dioxide levels in the blood due to respiratory failure. It aims to find which setting works better for patients at Lenox Hill Hospital.
New York, New YorkAges 18 years+
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Common questions
- Are there clinical trials for chronic respiratory failure?
- Yes. Clin2 currently lists 93 recruiting chronic respiratory failure studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic respiratory failure trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic respiratory failure trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.