Clinical trials
Sarcoma clinical trials
Below are recruiting sarcoma clinical trials, each written for real people, not researchers. We’re tracking 410 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06514313RecruitingPhase 2
Study of a drug combo for children with returning soft tissue sarcoma
This trial tests a combination of three drugs (VIM and VIT) for children and young adults whose soft tissue sarcoma has come back or not responded to previous treatments. The goal is to see if this new combination can help shrink or control the tumor.
Guangzhou, GuangdongAges 2–21 - NCT06564272RecruitingPhase 2
Study of KC1036 for teens with advanced Ewing sarcoma
This trial tests an experimental drug, KC1036, for adolescents with advanced Ewing sarcoma that has not responded to other treatments. It aims to see if the drug can help shrink tumors or slow the cancer.
Beijing, Beijing MunicipalityAges 12–18 - NCT06593899RecruitingPhase 2
Chemotherapy and radiation before surgery for arm or leg sarcoma
This trial tests giving chemotherapy and radiation therapy together before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach can improve outcomes for people with larger, high-grade, or deep tumors.
Fuzhou, FujianAges 18–75 - NCT06638931RecruitingPhase 2
Nivolumab for rare solid tumors with high PD-L1
This trial is testing a drug called Nivolumab (an immunotherapy) for people with rare solid tumors that have high levels of PD-L1. It might be an option if you have tried other treatments and they stopped working or caused too many side effects.
Fortaleza, CearáAges 18 years+ - NCT06669013RecruitingPhase 3
Chemo-immunotherapy for young people with bone or soft tissue sarcoma
This trial tests whether adding immunotherapy (a treatment that helps your immune system fight cancer) to chemotherapy can help young people whose bone or soft tissue sarcoma has come back or hasn't responded to previous treatment.
Saint PetersburgAges Up to 18 years - NCT06699472RecruitingPhase 2
Study of trilaciclib to prevent low blood counts in Ewing's sarcoma chemotherapy
This trial tests whether the drug trilaciclib can reduce low blood cell counts caused by chemotherapy in people with Ewing's sarcoma. If you qualify, you may receive a medication that could help protect your bone marrow during treatment.
Shanghai, Shanghai MunicipalityAges 14–40 - NCT07685405Recruiting
Biomarker study for Ewing sarcoma
This study looks for special markers called 'biomarkers' in the blood of people with Ewing sarcoma and compares them to people without cancer. It aims to find new ways to understand and potentially monitor this tumor using tiny particles in the blood.
Bologna, BOAges Any age - NCT06751355Recruiting
Precision imaging for Kaposi sarcoma
This trial tests a special imaging device to see if it can better evaluate Kaposi sarcoma skin lesions. It may help doctors understand the extent of the disease without relying only on physical exams.
St Louis, MissouriAges 18 years+ - NCT06760221Recruiting
Spotlight on bone cancer: SBRT plus surgery
This trial tests if giving a high dose of focused radiation (SBRT) before surgery can improve outcomes for people with aggressive soft tissue sarcoma in an arm or leg. You may be able to avoid chemotherapy and still have a good result.
Hangzhou, ZhejiangAges 18–80 - NCT06789172RecruitingPhase 1
New drug OKN4395 with or without pembrolizumab for solid tumors
This trial tests a new oral drug called OKN4395, which targets a COX2-related immune pathway, alone or with the immunotherapy pembrolizumab, in people with advanced solid tumors. It may be an option if you have certain types of cancer that have stopped responding to other treatments.
Beverly Hills, CaliforniaAges 18 years+ - NCT06805669Recruiting
Early palliative care for advanced soft tissue sarcoma
This study tests whether adding palliative care early on to standard cancer treatment improves quality of life for people newly diagnosed with advanced or metastatic soft tissue sarcoma.
Toronto, OntarioAges 18 years+ - NCT06805773Recruiting
Educational videos for newly diagnosed sarcoma patients
This study tests whether watching short educational videos helps patients or caregivers of someone with advanced sarcoma that has spread. The trial focuses on people who haven't had any prior treatment for their sarcoma and are comfortable filling out questionnaires in English.
Toronto, OntarioAges 18 years+ - NCT06815666RecruitingPhase 2
Lung fluid study for sarcoma patients having surgery
This study looks at fluid from the lungs of people with soft tissue sarcoma who are having surgery to remove a lung tumor. Researchers hope these samples can help understand the disease better.
Toronto, OntarioAges 18 years+ - NCT06827717RecruitingPhase 2
Liposomal irinotecan combo for advanced Ewing sarcoma
This trial tests a combination of three drugs (liposomal irinotecan, temozolomide, and fluzoparib) for people with Ewing sarcoma that has spread or come back after first treatment. The goal is to see if this combination can help shrink tumors or slow the disease.
Guangzhou, GuangdongAges 18–75 - NCT06829654Recruiting
Reimplanting frozen ovarian tissue in sarcoma and blood cancer survivors
This study looks at transplanting ovarian tissue that was frozen before cancer treatment to help restore fertility and hormone function in people who survived sarcomas or blood cancers. It aims to see if this procedure is safe and effective.
BolognaAges 18–38 - NCT06835049RecruitingPhase 2
Heating therapy before surgery for high-risk soft tissue sarcoma
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
AarauAges 18 years+ - NCT06848582Recruiting
NK cell therapy for high-risk pediatric soft tissue sarcoma
This trial tests whether giving immune cells called NK cells from donated umbilical cord blood can help children and teens with high-risk or returning soft tissue sarcoma. The goal is to see if it is safe and effective when other treatments have been tried.
Guangzhou, GuangdongAges Up to 18 years - NCT06849986RecruitingPhase 2
Immunotherapy & AI for first-line soft tissue sarcoma
This trial tests a combination of immunotherapy (a treatment that helps your immune system attack cancer) and artificial intelligence (AI) technology as the first treatment for certain types of advanced soft tissue sarcoma. It aims to see if this approach can shrink tumors or stop them from growing better than current options.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06873685Recruiting
Soft tissue sarcoma: surgery, rehab, and nutrition study
This trial is for people with a newly diagnosed soft tissue sarcoma that has not spread. It will study how surgery, physical therapy, and nutrition affect your recovery and quality of life.
Rome, LazioAges 18 years+ - NCT06889766RecruitingPhase 1
NY-ESO-1 T cells for advanced melanoma and sarcoma
This trial tests a personalized cell therapy using your own immune cells (T cells) that have been modified to recognize a protein called NY-ESO-1, which is found on some melanoma and sarcoma tumors. It may help people whose cancer has progressed after standard treatments.
Lausanne, Canton of VaudAges 18 years+ - NCT06905132RecruitingPhase 2
Short radiation before surgery for soft tissue sarcoma
This study tests a 5-day course of radiation before surgery instead of the usual 5 weeks. It may help people who face challenges like travel or tumor growth that make the longer schedule difficult.
Charleston, South CarolinaAges 18 years+ - NCT06958107Recruiting
Liquid biopsy study for sarcoma patients
This study uses a simple blood test (liquid biopsy) to look for tiny pieces of tumor DNA in people with sarcoma. It may help doctors learn more about the disease and guide treatment decisions, whether you are just diagnosed, being treated, or have finished treatment recently.
Charlotte, North CarolinaAges Any age - NCT06962072Recruiting
Outcomes after limb-sparing surgery for soft tissue sarcoma
This study looks at how well patients do after surgery to remove a soft tissue sarcoma from an arm or leg while saving the limb. It helps doctors understand recovery and function after this type of surgery.
AmsterdamAges 18 years+ - NCT06980259Recruiting
Comparing two types of radiation for soft tissue sarcoma
This trial tests a newer way of giving radiation (spatially fractionated) compared to standard radiation for people with large soft tissue sarcomas. It aims to see if the new method works better.
Jinan, ShandongAges 18–70
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Common questions
- Are there clinical trials for sarcoma?
- Yes. Clin2 currently lists 410 recruiting sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.