Clinical trials
Sarcoma clinical trials
Below are recruiting sarcoma clinical trials, each written for real people, not researchers. We’re tracking 401 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05111964Recruiting
Ultrasound treatment for soft tissue sarcoma tumors
This trial tests a non-surgical ultrasound treatment (HIFU) that targets the tumor from the outside of the body. It may help by shrinking or controlling certain types of soft tissue sarcoma or desmoid tumors when they are hard to remove surgically or when surgery/chemo/radiation is not a good option.
Oxford, OxfordshireAges 18 years+ - NCT05054335Recruiting
Testing personalized walking models for pelvic sarcoma surgery rehab
This study uses personalized computer models and movement measurements (often with MRI) to improve how surgery and physical rehab plans are tailored after pelvic sarcoma surgery. It aims to better understand walking and movement patterns so rehabilitation can be more effective.
Houston, TexasAges 18 years+ - NCT04941274RecruitingPhase 1/Phase 2
Abemaciclib for Kaposi sarcoma in people with or without HIV
This Phase 1/2 study tests the medicine abemaciclib to shrink Kaposi sarcoma (KS) lesions and control the disease. It includes both people with HIV and people without HIV, and may help when KS has not responded well to prior treatment or when certain KS stages are present.
Bethesda, MarylandAges 18–99 - NCT04921917Recruiting
Exercise during treatment for soft tissue sarcoma in an arm or leg
This trial studies whether adding an exercise program helps people with soft tissue sarcoma in an arm or leg during a planned treatment course. The treatment they look at is radiation before surgery, then surgery to remove the tumor, and they want to see how exercise affects outcomes and recovery.
Durham, North CarolinaAges 18–85 - NCT04851119RecruitingPhase 1/Phase 2
Tegavivint for kids and young adults with hard-to-treat solid tumors
This early-phase study tests tegavivint to see how well it works and how safe it is for children and young adults with solid cancers that have come back or are not responding. It may be an option if your tumor type (including certain lymphomas or desmoid tumors) matches the study’s rules.
Birmingham, AlabamaAges 1–30 - NCT04771520RecruitingPhase 2
Avapritinib for tumors with specific KIT or PDGFRA changes
This Phase 2 trial studies avapritinib, a targeted medicine, for people whose cancer has specific KIT or PDGFRA genetic changes. It may help shrink or slow growth of certain advanced cancers, including some brain tumors, when standard treatments have not worked or for specific glioblastoma cases.
Houston, TexasAges 18 years+ - NCT04698785RecruitingPhase 2
Regorafenib to help prevent cancer return after treatment
This Phase 2 study tests whether regorafenib, given after your main treatments, can help keep high-grade bone sarcoma from coming back or progressing. It checks safety and whether this “maintenance” approach works better than best supportive care alone.
BesançonAges 12 years+ - NCT04605770RecruitingPhase 2
Pemetrexed and cisplatin for advanced soft tissue cancer
This Phase 2 trial tests whether pemetrexed plus cisplatin can shrink advanced or metastatic soft tissue sarcoma. It may help people whose cancer has spread and who can safely receive chemotherapy.
SeoulAges 19 years+ - NCT04383119RecruitingPhase 2
Study for advanced leiomyosarcoma after prior chemo
This Phase 2 trial studies how well gemcitabine or trabectedin works for people with leiomyosarcoma that cannot be fully removed or has spread. It’s for tumors that have grown or worsened despite prior standard chemotherapy.
Bologna, BOAges 18 years+ - NCT04461171Recruiting
Better recovery steps after surgery for arm or leg tumors
This trial looks at whether an organized “enhanced recovery” plan can help people recover better after surgery for a suspected sarcoma in the arm or leg. If you’re having surgery at Vanderbilt, it may support faster, smoother recovery regardless of whether you use opioid pain medicine before surgery.
Nashville, TennesseeAges 18 years+ - NCT04305691RecruitingPhase 2
Ixazomib for skin Kaposi sarcoma in people with HIV
This trial studies ixazomib (a targeted anti-cancer medicine) to treat cutaneous (skin) Kaposi sarcoma. It aims to shrink measurable skin lesions and improve symptoms, especially in people living with HIV.
San Diego, CaliforniaAges 18 years+ - NCT04303117RecruitingPhase 1/Phase 2
Test drug PDS01ADC alone and with immunotherapy for Kaposi sarcoma
This Phase 1/2 study tests PDS01ADC, a targeted cancer drug, for advanced Kaposi sarcoma (KS). It also studies how well the drug works when added to the immunotherapy M7824, especially if KS has not responded to prior treatments.
Bethesda, MarylandAges 18–99 - NCT04307277RecruitingPhase 3
Chemotherapy before and after surgery for high-risk soft tissue sarcoma
This trial tests whether giving chemotherapy both before and after surgery helps people with high-risk soft tissue sarcoma live longer and prevents the cancer from coming back. It aims to see if this treatment plan is more effective than surgery alone.
BesançonAges 18 years+ - NCT04219202Recruiting
Pre-surgery radiation for retroperitoneal soft tissue cancer
This study tests giving special radiation (ions) before surgery for a specific cancer in the back of the abdomen (retroperitoneal soft tissue sarcoma). The goal is to shrink or control the tumor so surgery may be safer or more effective.
HeidelbergAges 18 years+ - NCT04031677RecruitingPhase 3
Surgery with or without chemotherapy for high-risk retroperitoneal sarcoma
This trial studies whether adding chemotherapy before surgery helps people with high-risk retroperitoneal (abdominal-area) leiomyosarcoma or liposarcoma. The goal is to improve outcomes while comparing surgery alone versus surgery plus neoadjuvant chemotherapy.
Birmingham, AlabamaAges 18 years+ - NCT04040205RecruitingPhase 2
Abemaciclib for sarcoma with specific cell-growth gene changes
This trial tests abemaciclib (a cancer medicine) in adults with advanced, unresectable bone or soft-tissue sarcoma that has certain gene changes in the “CDK pathway.” It aims to shrink tumors or slow growth in people whose tumors match the study’s biomarker and lab requirements.
Jacksonville, FloridaAges 18 years+ - NCT03818412Recruiting
Liquid biopsy for soft tissue sarcoma
This study checks if a blood test can detect DNA from soft tissue sarcomas. The goal is to see if circulating tumor DNA can help doctors monitor the disease and plan treatment.
Toronto, OntarioAges 18 years+ - NCT03823144Recruiting
Imaging small live tumor details during surgery
This study uses a special camera to look at solid tumors from inside the body during an operation. It tests whether “live” tumor imaging (using a medicine called fluorescein) can be safely performed in people with certain solid cancers.
Jacksonville, FloridaAges 18 years+ - NCT03715933RecruitingPhase 1
Test drug INBRX-109 for advanced or metastatic solid tumors
This Phase 1 trial tests INBRX-109, a cancer-targeting drug, in people whose solid cancers are locally advanced or spread to other parts of the body. Because it’s Phase 1, the main goal is to see whether it’s safe and how well it can work for different tumor types that meet specific requirements.
Scottsdale, ArizonaAges 12–85 - NCT03624244RecruitingPhase 2
Stopping or continuing hormone pill for low-grade uterine cancer
This Phase 2 trial tests whether it is better to stop a hormone tablet (an aromatase inhibitor) versus keep taking it in people with low-grade endometrial stromal sarcoma whose cancer is currently controlled. It may help find the safest way to maintain disease control while avoiding unnecessary treatment if stopping is possible.
BesançonAges 18 years+ - NCT03465592RecruitingPhase 1/Phase 2
Nivolumab after mismatched bone marrow transplant for sarcoma
This trial studies nivolumab (an immune treatment) in people with sarcoma who already had a partially mismatched bone marrow transplant. It may help the new immune system recognize and attack cancer, and researchers will also watch closely for side effects like GVHD (immune reaction after transplant) and autoimmune problems.
St. Petersburg, FloridaAges 1–40 - NCT03054792Enrolling by invitationPhase 1
MRI test to map low-oxygen areas in childhood sarcomas
This Phase 1 study uses special MRI scans to look at “low-oxygen” parts of a childhood sarcoma. It aims to help doctors better understand the tumor before standard treatment that may include chemotherapy and sometimes radiation.
Toronto, OntarioAges 6–18 - NCT03175718Recruiting
Pre-surgery radiation to reduce complications after leg sarcoma surgery
This study looks at whether giving radiation before surgery can lower wound healing problems and improve outcomes after operating on a leg soft-tissue sarcoma. It focuses on patients whose surgeons can close the wound directly after surgery and who can return for follow-up visits.
Ottawa, OntarioAges 18 years+ - NCT02789384Recruiting
Study of tumor markers to predict chemotherapy benefit in sarcoma
This study looks at stored tumor tissue (or takes a new biopsy) to measure specific tumor markers. Researchers want to see whether these markers match how well chemotherapy works before surgery for soft-tissue sarcoma.
BordeauxAges 18 years+
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Common questions
- Are there clinical trials for sarcoma?
- Yes. Clin2 currently lists 401 recruiting sarcoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a sarcoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a sarcoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.