Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06888219Enrolling by invitation
Acupuncture for Swallowing and Tube Removal After Brain Injury
This study tests if acupuncture on the ear and body can help people with severe brain injuries regain the ability to swallow safely and have their breathing tube removed. It's for patients who are at least 1 month but no more than 3 months after a stroke or brain bleed.
FlorenceAges 18 years+ - NCT05929833Enrolling by invitation
Brain injury education program for recovery at home
This study tests a recovery-focused brain injury education and support program for people with traumatic brain injury (TBI) who plan to go home after hospital stay. If you qualify, you and a caregiver/friend may get training and therapy support aimed at improving recovery.
Durham, North CarolinaAges 18 years+ - NCT06163833RecruitingPhase 2
Stem cell treatment for severe traumatic brain injury
This study tests whether a treatment made from donor stem cells (called mesenchymal stromal cells) can help people recover from a severe traumatic brain injury. The cells are given through a vein within 48 hours of the injury.
Monza, MBAges 18–70 - NCT07215195Recruiting
Brain injury, sleep, and mental health study
This study looks at how brain injuries affect sleep and mental health in the months after injury. It is for people who have had a stroke, brain bleed, or traumatic brain injury within the past year and are willing to let the research team contact their doctor if needed.
OxfordAges 18 years+ - NCT05236010Recruiting
Brain stimulation plus cognitive training for mild TBI memory and thinking
This trial studies whether brain stimulation through the scalp can improve cognitive (thinking and memory) training in people with chronic mild traumatic brain injury (TBI). Participants train on thinking tasks while receiving a targeted “control network neuromodulation” approach to see if it enhances training results.
Minneapolis, MinnesotaAges 18–59 - NCT04349852Recruiting
Memory and attention training for adults after brain injury
This trial tests a therapy that helps improve verbal working memory and attention in adults who had a traumatic brain injury (TBI). It may help by training thinking skills that are often affected after an injury, but it’s only for people who meet timing and mental health substance-use requirements.
New York, New YorkAges 18 years+ - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT05716048RecruitingPhase 1
Rehab program study for adults with lasting brain injury symptoms
This Phase 1 trial tests a combined rehabilitation program to improve function in people living with moderate-to-severe traumatic brain injury (TBI) for at least a year. It may help people who still have new problems with learning and memory and who are not very physically active.
West Orange, New JerseyAges 18–65 - NCT05885529Recruiting
Blood and CT tests after a concussion to track brain injury
This study checks whether two blood proteins (GFAP and UCH-L1) can help identify which brain spots are linked to a significant head injury after a concussion. You may be able to help by providing a blood sample and getting a CT scan as part of usual care, so doctors can better sort out injury risk.
AngersAges 18 years+ - NCT05889650Recruiting
External drainage for severe TBI brain swelling
This study tests whether placing an external drainage tube in the lower back can reduce dangerous pressure in the brain after a severe traumatic brain injury. If you meet safety and brain-scan criteria, it may help the research team understand whether this approach is safe early after injury.
Gainesville, FloridaAges 18–65 - NCT06103201RecruitingPhase 1
Special MRI for Traumatic Brain Injury Recovery
This trial uses a special MRI scan to look at how your brain uses energy after a traumatic brain injury. The goal is to better understand brain healing and find new ways to help people recover.
Baltimore, MarylandAges 18–80 - NCT06127459Recruiting
Virtual reality to help kids with brain injury improve thinking skills
This trial tests if virtual reality exercises can help children aged 8-12 with mild or moderate traumatic brain injury improve their attention and thinking skills. It is designed for children whose challenges were confirmed by a psychologist and who speak Finnish.
OuluAges 8–12 - NCT06146062RecruitingPhase 2
Stem cell therapy for severe traumatic brain injury
This trial tests whether a single infusion of stem cells from donated umbilical cord tissue can help calm inflammation in the brain after severe traumatic brain injury. It is for patients aged 18–50 who need brain pressure monitoring and are not responding to verbal commands 5 days after sedation is stopped.
ClamartAges 18–50 - NCT06184295Recruiting
Robotic balance training for better balance after brain injury
This study tests whether training on a robotic device can help improve balance and posture for people who had a traumatic brain injury (TBI) within the last 6 months to 5 years. It may help if you have some balance issues and can stand without support for 5 minutes.
West Orange, New JerseyAges 18–65 - NCT06581003RecruitingPhase 3
Hyperbaric oxygen for veterans with lasting brain injury symptoms
This trial tests whether breathing pure oxygen inside a pressurized chamber (hyperbaric oxygen therapy) can help reduce long-term symptoms after a mild or moderate traumatic brain injury. It is for veterans and service members who have had a TBI at least one year ago and are still struggling with symptoms.
Tampa, FloridaAges 18–75 - NCT06734026Recruiting
Enriched environment rehab for chronic brain injury
This study tests a rich, supportive environment (including exercise, social activities, and cognitive tasks) to help people with chronic brain injury improve their mobility and overall function. If you have a brain injury that happened more than 3 months ago and can stand with support, you may be able to join a program that focuses on your recovery.
Cleveland, OhioAges 18 years+ - NCT06816199Recruiting
Hyperbaric oxygen for traumatic brain injury recovery
This trial tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps people recover from traumatic brain injury. It aims to see if this treatment is safe and can improve healing for patients starting rehabilitation.
Hangzhou, ZhejiangAges 18–90 - NCT06871124Recruiting
Early brain stimulation for traumatic brain injury
This study tests whether early brain stimulation can help recovery after a moderate to severe traumatic brain injury (TBI). It might help improve thinking and awareness in patients who can already speak and follow directions.
Cincinnati, OhioAges 18–80 - NCT06953674RecruitingPhase 3
Saline versus balanced fluids for traumatic brain injury
This trial compares two types of intravenous fluids (saline vs. balanced crystalloids) given to people with traumatic brain injury when they arrive in the emergency room. The goal is to find out which fluid leads to better outcomes.
Louisville, KentuckyAges 18 years+ - NCT06956404Recruiting
Light therapy for older adults with traumatic brain injury
This study tests whether a painless light therapy applied to the head can help older adults (55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. It aims to see if the treatment improves thinking and memory.
New York, New YorkAges 55–85 - NCT06958406Recruiting
Brain-heart connection after head injury
This study uses brain scans (MRI) to understand how a traumatic brain injury can affect the heart. It may help find better ways to treat the brain-heart connection after a head injury.
ShanghaiAges 18–80 - NCT07072624RecruitingPhase 4
Preventing seizures after severe head injury
This trial tests whether giving medication right after a serious head injury can prevent early seizures. It may help people with certain types of brain injuries seen on CT scans.
Chandigarh, PunjabAges 18–70 - NCT07074938Recruiting
Traditional Chinese medicine for brain injury recovery
This trial tests whether a traditional Chinese medicine called An Gong Niuhuang Wan can help people recover brain function after a traumatic brain injury and surgery. It may be a good fit if you are moderately affected (GCS 6–12) and your condition is stable enough to start treatment within three days.
Wuhan, HubeiAges 18–60 - NCT07092423Recruiting
Special liquid tube feed for brain injury patients
This study tests a special liquid formula (semi-elemental nutrition) given through a feeding tube to people with severe traumatic brain injury. It aims to see if this formula is easier on the stomach and causes fewer digestive problems than standard tube feeds.
Xi'an, ShaanxiAges 18–75
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 266 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.