Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06024122Recruiting
Brain development after mild concussion in young children
This study looks at how a mild concussion affects brain development in young children (ages 3–5) compared to kids with other minor injuries like a broken arm. It involves one MRI scan and some simple check-ups to see how the brain heals over time.
RennesAges 3 years–5.9 years - NCT05446584RecruitingPhase 2
Study memory changes in people with past mild head injury
This Phase 2 study looks at how memory problems (amnestic mild cognitive impairment) may relate to a history of a mild traumatic brain injury. It compares people with a past mild head injury to people without one to better understand what might be driving memory symptoms.
Dallas, TexasAges 55 years+ - NCT07127224Recruiting
Predicting recovery with smell tests in coma
This study tests whether a simple smell test can help predict recovery of consciousness in patients who remain in a coma or minimally conscious state after a severe brain injury. If you or your loved one has been unresponsive for several days after sedation is stopped, this trial may provide useful information about prognosis.
Paris, GHU Psychiatrie Et NeurosciencesAges 18 years+ - NCT07535593RecruitingPhase 2/Phase 3
Electrical Acupoint Stimulation for Consciousness Disorders
This trial tests a non-invasive treatment called transcutaneous electrical acupoint stimulation (TEAS) to help people recover consciousness after severe brain injury. The treatment uses mild electrical pulses on specific points on the hands and may help improve awareness and responsiveness.
Xi'an, ShaanxiAges 18–80 - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT06797752Recruiting
Stellate ganglion block and retina blood flow study
This trial looks at how a nerve block (stellate ganglion block) affects blood flow in the retina. It may help people who already get this block for conditions like complex regional pain syndrome understand eye effects.
Dallas, TexasAges 18 years+ - NCT06939348Recruiting
Ultrasound therapy for patients with consciousness disorders
This trial tests whether ultrasound stimulation can help people with disorders of consciousness, like coma or a minimally conscious state. It aims to improve brain function and recovery for patients who have been injured for over a month.
Los Angeles, CaliforniaAges 18–79 - NCT07456020Recruiting
Measuring awareness after brain injury in the ICU
This study checks how awake and aware you are using two standard checklists (CRS-R and SECONDs). It's for people with recent brain injuries in intensive care who are still very dependent.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT07606300Recruiting
Light Training to Help Light Sensitivity After Head Injury
This trial tests whether a training program using colored light targets can help reduce light sensitivity (photophobia) that some people experience after a traumatic brain injury. The training involves focusing your eyes on lights during several visits.
Columbus, OhioAges 18–80 - NCT06583252Recruiting
Monitoring care for severe traumatic brain injury
This study tests a special monitoring approach for people with severe traumatic brain injury who are not opening their eyes or following commands. The goal is to see if close watching and coordinated care can improve recovery.
Changsha, HunanAges 18 years+ - NCT05566431Recruiting
Check monitoring for high brain pressure after child head injury
This study looks at a way of measuring and responding to high pressure inside the brain in children after a non-penetrating head injury. It may help doctors decide which monitoring approach works best for children who are very sick right after injury or become worse quickly.
Seattle, WashingtonAges 1–12 - NCT06839079Recruiting
Brain training for trauma survivors with head injury
This study tests a cognitive rehabilitation program for people with traumatic brain injury who have also experienced war, violence, or other trauma. It aims to improve memory and thinking skills using exercises and strategies.
Boston, MassachusettsAges 18–65 - NCT07664358Recruiting
Predicting lung injury after traumatic brain injury
This study looks at whether a simple blood test measuring fibrinogen and albumin levels can help predict if someone with a traumatic brain injury will develop a serious lung condition called acute respiratory distress syndrome (ARDS). It may help doctors identify patients who need extra monitoring and care.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06866691RecruitingPhase 4
Seizure prevention after traumatic brain injury
This trial tests two medicines, levetiracetam and lacosamide, to see which works better at preventing seizures in people who have had a traumatic brain injury. The goal is to find the safest and most effective way to protect your brain after injury.
Winston-Salem, North CarolinaAges 18 years+ - NCT07256704Recruiting
Hypnosis and Attention in Brain Conditions
This study tests whether hypnosis can help improve attention and focus in people with stroke, traumatic brain injury, or multiple sclerosis. It involves an EEG (a test that records brain activity) to see how the brain responds.
LucerneAges 18 years+ - NCT07385105Recruiting
CBT for insomnia after mild brain injury
This study tests whether a type of talk therapy called cognitive behavioral therapy for insomnia can help people with mild traumatic brain injury sleep better. It focuses on those who have had sleep problems for over a month.
Columbia, MissouriAges 18–60 - NCT07568301Enrolling by invitation
Music and nature self-care for brain injury survivors
This study explores whether music and nature-based activities can help people who have experienced brain injuries (like stroke or traumatic brain injury) and their caregivers manage stress and improve wellbeing. You and a care partner would participate together in the program.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT06923683Enrolling by invitation
Social skills treatment for brain injury
This trial tests a treatment called T-ScEmo for people with brain injury who have trouble with social skills and emotions. The treatment involves you and a support person (like a partner or close friend) working together to improve social understanding and behavior.
Boekel, North BrabantAges 18–70 - NCT03502967Enrolling by invitationEarly Phase 1
Hyperpolarized carbon-13 brain scan for recent traumatic brain injury
This early study tests a special brain imaging scan that looks at brain metabolism after a recent concussion/traumatic brain injury (TBI). It may help researchers understand what’s happening in the brain soon after injury.
Dallas, TexasAges 18–60 - NCT05819008Recruiting
Online brain testing for people with neurological conditions
This trial studies how well a remote, online memory and thinking assessment works for people with neurological disorders or injuries. You may be invited if you can do the computer-based testing and speak Swedish.
UmeåAges 18 years+ - NCT07109804Recruiting
Deep brain stimulation to improve walking after spinal cord injury
This study tests whether stimulating a small area deep in the brain (the cuneiform nucleus) with a device called deep brain stimulation (DBS) can help people walk better after a spinal cord injury. The goal is to see if it improves walking speed and stability.
Miami, FloridaAges 22–70 - NCT04869059Recruiting
tDCS for mild brain injury memory word finding
This trial tests whether a noninvasive brain stimulation treatment (tDCS) can improve word-retrieval problems after a mild or moderate concussion-like brain injury. It may help if testing shows trouble finding the right words when speaking.
Dallas, TexasAges 18–75 - NCT07135791Recruiting
Tracking daily fatigue in adults with brain injury or cerebral palsy
This study uses a smartphone app to track how fatigue changes throughout the day in adults with cerebral palsy or acquired brain injury. The goal is to better understand fatigue patterns so doctors can offer better support.
Glostrup MunicipalityAges 30–65
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 266 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.