Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 276 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07732374RecruitingPhase 2
Long-term results after hyperbaric oxygen therapy in veterans
This study follows veterans who previously finished a 40-session hyperbaric oxygen therapy (HBOT) program. It tracks how their memory, mood, and daily function are doing 12 weeks later, to understand long-term benefits.
Boise, IdahoAges 18 years+ - NCT06698172Recruiting
Home vision training to improve movement after brain injury
This study tests whether home-based visual exercises can improve movement skills in people who have vision loss after a stroke or head injury. If you have partial blindness (on one side or top/bottom) and your brain injury is more than 6 months old, this program may help you regain motor function.
Zaragoza, ZaragozaAges 18–80 - NCT07624825Recruiting
Emotional Awareness Therapy After Brain Injury
This study tests whether a therapy focused on recognizing and understanding emotions can help people recover better after a moderate or severe traumatic brain injury (TBI). You'll participate if you're at least 6 months past your injury and struggle to identify or describe your feelings.
Edison, New JerseyAges 18 years+ - NCT07625098RecruitingPhase 1
Social Support Program for People After Brain Injury
This study tests whether a program that helps connect people with social support can improve quality of life for adults living at home after a traumatic brain injury. You might qualify if your injury happened more than 6 months ago and you feel isolated or lack strong social connections.
St Louis, MissouriAges 18 years+ - NCT06473987Recruiting
Virtual reality training for better walking after brain injury
This trial tests a virtual reality program that combines thinking and walking exercises to help improve your balance and walking speed. It may be a good fit if you have a traumatic brain injury and walk more slowly than usual.
West Orange, New JerseyAges 18–65 - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT07549997RecruitingPhase 1
Social Participation Recovery Program After Brain Injury
This study tests whether a group program can help people who've had a traumatic brain injury (TBI) get back to social activities they enjoyed before their injury. You'll work with others and learn strategies to re-engage with friends, family, and community.
St Louis, MissouriAges 18 years+ - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT07466589Recruiting
Electric stimulation for dizziness after concussion
This trial tests if a portable electric stimulation device can help improve balance and reduce dizziness in people recovering from a concussion. If you have had ongoing imbalance for at least 4-6 weeks, this study may help you feel steadier.
Ann Arbor, MichiganAges 18–55 - NCT06792877Recruiting
Mindfulness for thinking in early Alzheimer's
This study tests if mindfulness training can help protect thinking and memory in early-stage Alzheimer's disease. It compares mindfulness to other activities to see if it slows down memory loss.
Boston, MassachusettsAges 50–100 - NCT07448103Recruiting
Robot-assisted rehab for kids with brain injury
This trial uses a social robot and artificial intelligence to help children with acquired brain injury do rehabilitation exercises at the hospital or at home. The robot guides them through arm and hand activities to improve movement and recovery.
Madrid, MadridAges 7–16 - NCT07332299Recruiting
Brain stimulation and training for seniors with TBI
This study tests if a wearable brain stimulation device (tDCS) combined with computer-based training can improve attention and concentration in older veterans with a history of mild brain injury. It involves several sessions from home using a headset and computer.
Minneapolis, MinnesotaAges 65 years+ - NCT07319208RecruitingPhase 3
Testing a continuous infusion of a treatment for traumatic brain injury
This trial tests whether starting a continuous infusion of a concentrated salt solution (HSS) early in the ICU can improve brain recovery at 6 months in patients with traumatic brain injury. It may help control brain swelling and pressure.
AngersAges 18–75 - NCT07301710RecruitingPhase 1/Phase 2
Low-tech treatments for sleep apnea
This study tests simple, low-tech treatments (like exercises) for sleep apnea. It's for people who are newly diagnosed or whose current treatment isn't working, and who are willing to pause their usual treatment for 3 months.
Bethesda, MarylandAges 18–65 - NCT07282691Recruiting
Validating eye tests for mild brain injury
This study looks at eye tests for people who had a mild brain injury (mTBI) in the last 1 to 6 months. It aims to better understand and measure eye movement problems that can happen after such an injury.
Philadelphia, PennsylvaniaAges 18–35 - NCT06028334Recruiting
GetUp&Go: Helping you get active after a brain injury
This study tests a program to help people with traumatic brain injury become more physically active. You would use a smartphone app and get coaching to increase your daily movement, which may improve your recovery and quality of life.
Elkins Park, PennsylvaniaAges 18 years+ - NCT06589362Recruiting
Nerve stimulation plus cognitive training for brain injury recovery
This study tests if a gentle, noninvasive nerve stimulation (on the neck) combined with computerized thinking exercises can help people recovering from a traumatic brain injury improve memory and attention. It is for adults currently in inpatient rehab who can use a keyboard and are medically stable.
Chicago, IllinoisAges 18–65 - NCT06897553Recruiting
ACT for Better Mental Health with Neurologic Illness
This study tests a type of talk therapy (ACT) to help people with neurological conditions like Parkinson’s, MS, or epilepsy feel better emotionally. It's for those who are struggling with depression, anxiety, or stress and are ready to work on their mental health.
BielefeldAges 18 years+ - NCT07248995Recruiting
Ultrasound to set breathing support in brain injury patients with lung issues
This trial tests if chest and head ultrasound can help doctors adjust the breathing machine (PEEP) for patients with both a severe brain injury and a serious lung condition called ARDS. The goal is to improve care without harming the brain.
ThessalonikiAges 18 years+ - NCT07234890RecruitingPhase 2
Testing AV-001 to protect the brain during hemodialysis
This study tests a new medicine called AV-001 to see if it can protect the brain from damage caused by hemodialysis. If you qualify, you may help find a way to reduce thinking and memory problems linked to dialysis.
London, OntarioAges 18 years+ - NCT06292585Recruiting
Blocking the artery to treat epidural hematoma
This trial tests a new way to treat a blood clot outside the brain (epidural hematoma) after a head injury. Instead of surgery, doctors use a thin tube to block the artery feeding the clot, which may help the body absorb the clot more safely.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07214415RecruitingPhase 2
Hyperbaric oxygen therapy for veterans with brain injury or mental health issues
This trial tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve thinking, mood, and quality of life in veterans with mild traumatic brain injury, PTSD, anxiety, or depression. You must have already tried at least one evidence-based therapy like CBT or EMDR.
Boise, IdahoAges 18–75 - NCT07209657Recruiting
Familiar songs for children with brain injury
This study tests whether listening to familiar songs can increase awareness in children with disorders of consciousness after a severe brain injury. Your child may be eligible if they are in a low-responsive state and you can give consent.
Parkville, VictoriaAges 1–18
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 276 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.