Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 266 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05900778Recruiting
HABIT-ILE program for school-aged children after brain injury
This trial tests whether a structured HABIT-ILE program helps children with a brain injury improve daily functioning at school and during therapy sessions. It may help families build skills and routines, but it requires meeting specific health and timing criteria.
Ottignies-Louvain-la-Neuve, Brabant-WallonAges 5–18 - NCT05916417Recruiting
Personalized TMS dosing for PTSD using brain monitoring
This study tests a “personalized dosing” approach for transcranial magnetic stimulation (TMS) in adults with PTSD. It aims to see whether using brain measurements to guide the TMS settings can improve treatment while keeping participants safe.
Tallahassee, FloridaAges 18–70 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT06028334Recruiting
GetUp&Go: Helping you get active after a brain injury
This study tests a program to help people with traumatic brain injury become more physically active. You would use a smartphone app and get coaching to increase your daily movement, which may improve your recovery and quality of life.
Elkins Park, PennsylvaniaAges 18 years+ - NCT06034509Recruiting
Thinking and blood vessel health after head injury
This study looks at how a past traumatic brain injury (TBI) might affect your thinking skills and blood vessel health over time. You may be eligible if you had a TBI at least 3 years ago and have already completed an earlier evaluation at the National Intrepid Center of Excellence (NICoE).
Bethesda, MarylandAges 18–74 - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06098833RecruitingPhase 2
Sildenafil for newborn brain injury after birth asphyxia
This trial tests whether a liquid form of the medicine sildenafil can help repair brain damage in newborns who had a difficult birth and were treated with cooling. If your baby meets the cooling criteria and has brain injury on an MRI, this study may offer an additional treatment option.
Montreal, QuebecAges birth–2 days - NCT06148324Recruiting
Wellness program for traumatic brain injury recovery
This study tests a wellness program for people who had a moderate or severe traumatic brain injury (TBI) at least a year ago. The program is done online, so you can join from home, and it aims to help you with your recovery and well-being.
New York, New YorkAges 18–70 - NCT06222450Recruiting
Vestibular rehab app for dizziness after mild brain injury
This study tests a smartphone app with exercises to help improve balance and dizziness in people who have had a mild traumatic brain injury. You may be eligible if you are still experiencing dizziness or balance problems.
Tampa, FloridaAges 18 years+ - NCT06292585Recruiting
Blocking the artery to treat epidural hematoma
This trial tests a new way to treat a blood clot outside the brain (epidural hematoma) after a head injury. Instead of surgery, doctors use a thin tube to block the artery feeding the clot, which may help the body absorb the clot more safely.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06311604Recruiting
Inhaled sedation safety for head trauma patients
This trial tests a new way to give sedation through a breathing mask (isoflurane gas) to people with severe head injuries. It aims to see if this method is safe and may help when IV sedatives alone are not enough.
Grenoble, Choisir Une RégionAges 18 years+ - NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT06462703Recruiting
Tablet app for cognitive problems after brain injury
This study tests a tablet app designed to help with thinking and memory problems caused by a brain injury. You would use the app at home to practice attention, memory, and other mental skills.
ViennaAges 18 years+ - NCT06473987Recruiting
Virtual reality training for better walking after brain injury
This trial tests a virtual reality program that combines thinking and walking exercises to help improve your balance and walking speed. It may be a good fit if you have a traumatic brain injury and walk more slowly than usual.
West Orange, New JerseyAges 18–65 - NCT06494319Recruiting
PTSD treatment app for veterans with combat trauma
This study tests a virtual training program and mobile app to help veterans manage PTSD from combat. It aims to reduce symptoms and improve daily life.
Houston, TexasAges 18–79 - NCT06525584Recruiting
Ketamine to protect the brain during heart surgery in children
This study tests whether giving ketamine during heart surgery helps protect the brain in young children. It is for children aged 1 month to 5 years who are having surgery to fix a hole in the wall between the heart chambers (atrial or ventricular septal defect).
Kemerovo, Please SelectAges 1 month–5 years - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT06589362Recruiting
Nerve stimulation plus cognitive training for brain injury recovery
This study tests if a gentle, noninvasive nerve stimulation (on the neck) combined with computerized thinking exercises can help people recovering from a traumatic brain injury improve memory and attention. It is for adults currently in inpatient rehab who can use a keyboard and are medically stable.
Chicago, IllinoisAges 18–65 - NCT06698172Recruiting
Home vision training to improve movement after brain injury
This study tests whether home-based visual exercises can improve movement skills in people who have vision loss after a stroke or head injury. If you have partial blindness (on one side or top/bottom) and your brain injury is more than 6 months old, this program may help you regain motor function.
Zaragoza, ZaragozaAges 18–80 - NCT06707441Recruiting
Comparing two scores to predict chest injury outcomes
This study tests two different scoring systems (TTSS and TISS) to see which better predicts recovery in people with chest injuries like broken ribs, lung bruises, or collapsed lungs. Doctors use these scores soon after you arrive to guide treatment and predict how you'll do.
BaghdadAges 16 years+ - NCT06723743Recruiting
Nerve stimulation for attention and memory
This study tests if a gentle, non-invasive nerve stimulation device can help improve attention and memory in veterans with PTSD, depression, or mild brain injury. It uses a small device on the ear to stimulate a nerve that may influence brain function.
Houston, TexasAges 25–64 - NCT06792877Recruiting
Mindfulness for thinking in early Alzheimer's
This study tests if mindfulness training can help protect thinking and memory in early-stage Alzheimer's disease. It compares mindfulness to other activities to see if it slows down memory loss.
Boston, MassachusettsAges 50–100 - NCT06830291Recruiting
Validating a digital cognitive test for head trauma patients
This study aims to validate a digital cognitive assessment tool (Neuralix) for people who have experienced moderate to severe head trauma within the past 5 years. Participation helps ensure the tool is accurate and useful for monitoring recovery.
ClamartAges 18–65
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 266 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.