Clinical trials
Severe Brain Injury clinical trials
Below are recruiting severe brain injury clinical trials, each written for real people, not researchers. We’re tracking 276 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07202494Recruiting
Brain aging and resilience MRI study
This study uses powerful MRI scans to understand how the brain ages and why some people stay healthy while others develop neurological diseases like multiple sclerosis or Alzheimer's. It compares healthy volunteers to people with certain conditions, and all participants get a detailed brain MRI.
MarseilleAges 18–90 - NCT06909071Recruiting
Smart insulin pump for blood sugar control after brain surgery
This trial tests a smart insulin pump (hybrid closed-loop system) to control high blood sugar after brain surgery for bleeding strokes. It's for people with type 2 diabetes who are stable enough to leave the intensive care unit and are getting tube feedings.
Taiyuan, ShanxiAges 18–75 - NCT07176936Recruiting
Can ear stimulation improve hearing in noise?
This study tests whether a gentle, noninvasive ear stimulation device can help people hear speech better in noisy places. It is for people who have had a traumatic brain injury or those with normal hearing.
Gainesville, FloridaAges 25–55 - NCT07120373Recruiting
Sleep after traumatic brain injury: a wearable tracker study
This study looks at how sleep is affected after a traumatic brain injury (TBI). It uses a small wearable tracker to measure sleep patterns at home, either soon after the injury or a year or more later.
Nottingham, NottinghamshireAges 18–60 - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT07065916Enrolling by invitation
Arm More + Camp: Helping kids with arm weakness
This trial tests a program called 'Arm More + Camp' to help kids and teens with arm weakness due to cerebral palsy or a brain injury improve their movement. It’s a group camp-style study that fits into the school year.
Calgary, AlbertaAges 5–17 - NCT07055633Recruiting
Improving cognitive rehab for veterans with concussion and PTSD
This trial tests a program to help veterans with memory, attention, or thinking problems after a mild concussion (mTBI) and with PTSD. It also looks at depression and sleep issues. The goal is to improve thinking and daily life.
San Diego, CaliforniaAges 18 years+ - NCT07063446Recruiting
Brain stimulation with movement therapy for babies with one-sided weakness
This study tests if combining a gentle magnetic head device (sTMS), constraint therapy (CIMT), and a mild nerve stimulator (taVNS) can help babies with one-sided weakness move better. Families join for 2 weeks of treatment and a 3-month follow-up.
Charleston, South CarolinaAges 8 months–2 years - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT06988787Recruiting
Resilience therapy for veterans after trauma
This study tests a program to help female veterans who have experienced intimate partner violence or military sexual trauma and have stress symptoms. It aims to improve emotional well-being and resilience.
Houston, TexasAges 18 years+ - NCT06973018Enrolling by invitation
Online cognitive rehab for mild memory problems
This trial tests an online program to help people with mild to moderate cognitive problems after a brain injury or nervous system disease improve their thinking skills. It is for Swedish speakers with internet access.
Stockholm, Stockholm CountyAges 18 years+ - NCT06979466Recruiting
Electrical device for chronic stroke recovery
This trial tests a device that uses electrical stimulation to help people who had a stroke several months to years ago improve arm and hand movement. You would use the device while sitting and do physical exercises with help from a caregiver.
White Plains, New YorkAges 18–80 - NCT06930716Recruiting
Vagus nerve stimulation with physical therapy for consciousness disorders
This trial tests whether a mild electrical stimulation of the vagus nerve (a nerve in the neck) can help people with long-term disorders of consciousness move better during physical therapy. It may be an option if you are still in a coma, vegetative, or minimally conscious state and have been stable for more than 6 weeks.
New York, New YorkAges 22 years+ - NCT06920784Recruiting
Prismatic glasses therapy for brain injury rehabilitation
This trial tests whether wearing special prismatic glasses during cognitive exercises can help people recovering from a traumatic brain injury. It is designed for patients who are still in the early stages of recovery and have a certain level of consciousness and attention.
BariAges 18 years+ - NCT06893029Recruiting
Dizziness from visual motion in concussion and other causes
This study looks at how people with dizziness from concussion or other causes (like vestibular migraine) react to visual motion. It tests balance during specific visual challenges to understand why dizziness happens.
Zurich, Canton of ZurichAges 18–60 - NCT03170440Recruiting
Non-invasive nerve stimulation for PTSD and sleep
This study tests a non-invasive way to stimulate nerves without surgery in people with PTSD, especially looking at sleep and related symptoms. It may help by improving how your nervous system and sleep patterns work over time.
Gainesville, FloridaAges 18–55 - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT06855186Recruiting
Rehabilitation for concussion based on your symptoms
This study tests a symptom-focused rehabilitation program for people who had a mild traumatic brain injury (concussion) at least 3 months ago. It aims to help with ongoing cognitive complaints like memory or concentration problems.
Wahiawa, HawaiiAges 18–64 - NCT06830291Recruiting
Validating a digital cognitive test for head trauma patients
This study aims to validate a digital cognitive assessment tool (Neuralix) for people who have experienced moderate to severe head trauma within the past 5 years. Participation helps ensure the tool is accurate and useful for monitoring recovery.
ClamartAges 18–65 - NCT06819904Recruiting
Combined talk therapy and balance rehab for mild TBI
This trial tests a new type of therapy that combines acceptance and commitment therapy (a counseling approach) with vestibular rehabilitation (exercises for balance and dizziness). It's designed for people with mild traumatic brain injury who still have symptoms like dizziness, anxiety, or memory problems.
Pittsburgh, PennsylvaniaAges 18–49 - NCT06790095Enrolling by invitationPhase 2
Testing Cyclosporine for Moderate to Severe Brain Injury
This study tests a drug called cyclosporine to see if it can help people with moderate to severe traumatic brain injury. You may be eligible if you have a brain injury seen on CT and can start treatment within 24 hours.
San Francisco, CaliforniaAges 18–65 - NCT06707441Recruiting
Comparing two scores to predict chest injury outcomes
This study tests two different scoring systems (TTSS and TISS) to see which better predicts recovery in people with chest injuries like broken ribs, lung bruises, or collapsed lungs. Doctors use these scores soon after you arrive to guide treatment and predict how you'll do.
BaghdadAges 16 years+ - NCT06525584Recruiting
Ketamine to protect the brain during heart surgery in children
This study tests whether giving ketamine during heart surgery helps protect the brain in young children. It is for children aged 1 month to 5 years who are having surgery to fix a hole in the wall between the heart chambers (atrial or ventricular septal defect).
Kemerovo, Please SelectAges 1 month–5 years - NCT06465290Recruiting
Brain recovery treatment for recent stroke with ankle stiffness
This trial tests a treatment to help your brain recover after a stroke. It focuses on improving ankle movement and leg strength using exercises that promote brain rewiring.
Baltimore, MarylandAges 30–85
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Common questions
- Are there clinical trials for severe brain injury?
- Yes. Clin2 currently lists 276 recruiting severe brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.