Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06584591Recruiting
Balance training study for people with traumatic brain injury
This study tests a new balance training program called NEUROBALANCE to help improve postural control in people who have had a traumatic brain injury. It uses a non-invasive brain stimulation technique (TMS) to see if it can help improve balance and walking.
West Orange, New JerseyAges 18–75 - NCT07664358Recruiting
Predicting lung injury after traumatic brain injury
This study looks at whether a simple blood test measuring fibrinogen and albumin levels can help predict if someone with a traumatic brain injury will develop a serious lung condition called acute respiratory distress syndrome (ARDS). It may help doctors identify patients who need extra monitoring and care.
Tanta, Gharbia GovernorateAges 18 years+ - NCT06733025Recruiting
Comparing surgery and Botox for arm spasticity
This trial compares two treatments—Botox injections or surgery—for arm and hand spasticity after a stroke, brain injury, or spinal cord injury. It may help you decide which option works best for you.
MölndalAges 18 years+ - NCT06734026Recruiting
Enriched environment rehab for chronic brain injury
This study tests a rich, supportive environment (including exercise, social activities, and cognitive tasks) to help people with chronic brain injury improve their mobility and overall function. If you have a brain injury that happened more than 3 months ago and can stand with support, you may be able to join a program that focuses on your recovery.
Cleveland, OhioAges 18 years+ - NCT06816199Recruiting
Hyperbaric oxygen for traumatic brain injury recovery
This trial tests whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) helps people recover from traumatic brain injury. It aims to see if this treatment is safe and can improve healing for patients starting rehabilitation.
Hangzhou, ZhejiangAges 18–90 - NCT06836856RecruitingPhase 1/Phase 2
Beta blockers after traumatic brain injury: a study
This trial tests whether giving a beta blocker drug after a moderate or severe traumatic brain injury can improve recovery. It is for patients who have a brain injury but only minor or no other injuries.
ZagazigAges 18–75 - NCT06848140Recruiting
Brain stimulation for word-finding problems after TBI
This study tests whether non-invasive brain stimulation can help people with chronic traumatic brain injury (TBI) find words more easily. It involves sessions at Beth Israel Deaconess Medical Center in Boston.
Boston, MassachusettsAges 18–85 - NCT06851156Recruiting
Brain stimulation for disorders of consciousness after severe injury
This trial tests a new type of brain stimulation called transcranial temporal interference stimulation to see if it can help people with severe brain injury who are in a vegetative or minimally conscious state. It uses gentle electrical currents to try to improve awareness and recovery.
Xi'an, ShaanxiAges 18–65 - NCT06866691RecruitingPhase 4
Seizure prevention after traumatic brain injury
This trial tests two medicines, levetiracetam and lacosamide, to see which works better at preventing seizures in people who have had a traumatic brain injury. The goal is to find the safest and most effective way to protect your brain after injury.
Winston-Salem, North CarolinaAges 18 years+ - NCT06867666Recruiting
Behavioral sleep therapy for insomnia in Navy members with TBI
This study tests a behavioral talk therapy for insomnia (CBT-I) in active duty Sailors who also have a history of traumatic brain injury. You'll learn better sleep habits using an app and coaching, with the goal of improving your sleep and recovery.
San Diego, CaliforniaAges 18 years+ - NCT06871124Recruiting
Early brain stimulation for traumatic brain injury
This study tests whether early brain stimulation can help recovery after a moderate to severe traumatic brain injury (TBI). It might help improve thinking and awareness in patients who can already speak and follow directions.
Cincinnati, OhioAges 18–80 - NCT06873477Recruiting
Brain injury study for children and young adults
This study looks at children and young adults who have brain damage from a severe head injury or lack of oxygen at birth. It aims to learn more about these conditions and how to help patients.
Rome, LazioAges Up to 20 years - NCT06953674RecruitingPhase 3
Saline versus balanced fluids for traumatic brain injury
This trial compares two types of intravenous fluids (saline vs. balanced crystalloids) given to people with traumatic brain injury when they arrive in the emergency room. The goal is to find out which fluid leads to better outcomes.
Louisville, KentuckyAges 18 years+ - NCT06956404Recruiting
Light therapy for older adults with traumatic brain injury
This study tests whether a painless light therapy applied to the head can help older adults (55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. It aims to see if the treatment improves thinking and memory.
New York, New YorkAges 55–85 - NCT06958406Recruiting
Brain-heart connection after head injury
This study uses brain scans (MRI) to understand how a traumatic brain injury can affect the heart. It may help find better ways to treat the brain-heart connection after a head injury.
ShanghaiAges 18–80 - NCT06966713Recruiting
Predicting recovery after severe brain injury
This study looks at patients with severe traumatic brain injury (TBI) who already need brain pressure or oxygen monitoring. Doctors want to see if certain tests can help predict how well someone might recover.
Chicago, IllinoisAges 18 years+ - NCT07025317Recruiting
Study on concussions and brain training in older adults
This study looks at how repeated concussions affect the brain as we age. It tests a computer-based brain training program and uses MRI scans to see if training can help improve thinking and memory.
Victoria, British ColumbiaAges 60 years+ - NCT07056348Recruiting
Brain stimulation to improve movement in Parkinson's or tremor
This study tests brain stimulation in a region called VOP/VIM to see if it can improve motor function. It is for people with movement disorders who are already getting deep brain stimulation (DBS) surgery.
Pittsburgh, PennsylvaniaAges 18–80 - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT07072624RecruitingPhase 4
Preventing seizures after severe head injury
This trial tests whether giving medication right after a serious head injury can prevent early seizures. It may help people with certain types of brain injuries seen on CT scans.
Chandigarh, PunjabAges 18–70 - NCT07074938Recruiting
Traditional Chinese medicine for brain injury recovery
This trial tests whether a traditional Chinese medicine called An Gong Niuhuang Wan can help people recover brain function after a traumatic brain injury and surgery. It may be a good fit if you are moderately affected (GCS 6–12) and your condition is stable enough to start treatment within three days.
Wuhan, HubeiAges 18–60 - NCT07092423Recruiting
Special liquid tube feed for brain injury patients
This study tests a special liquid formula (semi-elemental nutrition) given through a feeding tube to people with severe traumatic brain injury. It aims to see if this formula is easier on the stomach and causes fewer digestive problems than standard tube feeds.
Xi'an, ShaanxiAges 18–75 - NCT07097792Recruiting
Concussion recovery support program for headaches
This study tests a support program for young people who have had a concussion and are still having headaches. It aims to help them recover and feel better.
Seattle, WashingtonAges 18–29 - NCT07105358Recruiting
Vision recovery study after brain damage
This study tests whether the brain can improve vision after damage caused by stroke, tumor, or injury. It may help people with vision loss from a brain lesion find new ways to see better.
Washington D.C., District of ColumbiaAges 18 years+
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 226 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.