Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 234 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05380050Recruiting
Comparing online and in-person memory training for veterans with mild brain injury and PTSD
This study compares two ways of delivering a memory and thinking skills program to veterans with both mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD). The goal is to see if doing the training online is as effective as doing it in person, which could make it easier for more veterans to get help.
Gainesville, FloridaAges 30–55 - NCT07248995Recruiting
Ultrasound to set breathing support in brain injury patients with lung issues
This trial tests if chest and head ultrasound can help doctors adjust the breathing machine (PEEP) for patients with both a severe brain injury and a serious lung condition called ARDS. The goal is to improve care without harming the brain.
ThessalonikiAges 18 years+ - NCT07065916Enrolling by invitation
Arm More + Camp: Helping kids with arm weakness
This trial tests a program called 'Arm More + Camp' to help kids and teens with arm weakness due to cerebral palsy or a brain injury improve their movement. It’s a group camp-style study that fits into the school year.
Calgary, AlbertaAges 5–17 - NCT06979466Recruiting
Electrical device for chronic stroke recovery
This trial tests a device that uses electrical stimulation to help people who had a stroke several months to years ago improve arm and hand movement. You would use the device while sitting and do physical exercises with help from a caregiver.
White Plains, New YorkAges 18–80 - NCT06707441Recruiting
Comparing two scores to predict chest injury outcomes
This study tests two different scoring systems (TTSS and TISS) to see which better predicts recovery in people with chest injuries like broken ribs, lung bruises, or collapsed lungs. Doctors use these scores soon after you arrive to guide treatment and predict how you'll do.
BaghdadAges 16 years+ - NCT02395497RecruitingPhase 2/Phase 3
Penile transplant trial using immune-suppressing medicines
This study tests whether a donated penis can be successfully transplanted using medicines that calm the immune system to prevent rejection. It also looks at safety and recovery of function in men with severe penile loss from injury, cancer surgery, or birth conditions.
Baltimore, MarylandAges 18–69 - NCT07472985Recruiting
Early cycling exercise after spinal cord injury
This trial tests if starting leg cycling exercise within the first week after spinal cord injury is safe and helpful. It is for adults who had surgery within 48 hours of their injury and have a specific level of paralysis.
Montreal, QuebecAges 18 years+ - NCT06127316Recruiting
Heel lift height and foot pressure with custom braces
This study tests if changing the height of a heel lift in a custom foot brace can improve how weight is distributed on your foot after a serious ankle or hindfoot injury. If you have pain when walking, this could help find better ways to reduce that pain.
Iowa City, IowaAges 18–65 - NCT06111976Recruiting
TMS plus reactivation therapy for resistant PTSD
This trial tests if adding a type of brain stimulation (TMS) to a memory reactivation therapy can reduce PTSD symptoms that haven't improved with standard antidepressants. If you have persistent PTSD, this study could offer a new treatment option.
ParisAges 18–65 - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT01894802Recruiting
Brain recording and stimulation to help control a computer
This study tests a brain-machine interface that records brain activity and uses stimulation to help people with severe hand/arm movement loss communicate or control tasks using a computer. It may help restore some control and reduce dependence on hands that cannot be used normally.
Chicago, IllinoisAges 22–70 - NCT06867809Recruiting
Spinal and brain stimulation for arm movement after neck injury
This study tests whether using a combination of spinal and brain stimulation can help improve arm and hand movement in people who have had a cervical spinal cord injury (neck area) at least one year ago. It is for those with some remaining movement but not full strength.
New York, New YorkAges 18 years+ - NCT06015451Recruiting
Exercise for concussion symptoms and headache
This trial tests whether a carefully supervised exercise program can help people who still have headaches or other symptoms weeks after a mild head injury. If you get symptoms when you try to be active, this study may offer a structured way to help you recover.
TrondheimAges 18–65 - NCT06433622Enrolling by invitation
Platelet transfusion for severe brain injury on blood thinners
This trial tests whether giving a platelet transfusion to patients with severe traumatic brain injury who are on antiplatelet medication can improve how well their blood clots. You may qualify if you have a serious brain bleed and are taking a medication like aspirin or clopidogrel.
Lancaster, PennsylvaniaAges 18 years+ - NCT07710417RecruitingEarly Phase 1
Float therapy for healthcare workers with PTSD
This study tests whether floating in a shallow pool of water can help reduce PTSD and stress-related symptoms in first responders and emergency medical personnel. If you're a healthcare worker struggling with work-related trauma, this floating therapy might offer relief.
Tulsa, OklahomaAges 18–64 - NCT05765864Recruiting
Study of self-harm in at-risk teens
This study looks at self-harm and thoughts/behaviors related to safety in teenagers who are considered at higher risk. It may help researchers better understand what supports are needed for teens who self-harm without wanting to die.
LjubljanaAges 13–18 - NCT05665998Recruiting
Brain-controlled spinal stimulation for arm rehab after neck injury
This study tests a brain-controlled spinal stimulation approach to improve arm (upper limb) movement after a neck spinal cord injury. It may help people who have very limited arm function after a stable, traumatic injury, using frequent training and device-related checks.
Lausanne, Canton of VaudAges 18–75 - NCT05865327Recruiting
Nerve freezing for rib-fracture pain using ultrasound guidance
This trial tests whether freezing a specific nerve (a “cryoneurolysis” treatment) through a catheter can better control pain from traumatic rib fractures. It’s offered to adults who have rib fractures soon after hospital admission and can use a pain control method called patient-controlled regional analgesia.
Toronto, OntarioAges 18–100
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 234 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.