Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06103201RecruitingPhase 1
Special MRI for Traumatic Brain Injury Recovery
This trial uses a special MRI scan to look at how your brain uses energy after a traumatic brain injury. The goal is to better understand brain healing and find new ways to help people recover.
Baltimore, MarylandAges 18–80 - NCT06109909Recruiting
Brain training for light sensitivity after mild head injury
This study tests if a type of brain training called neurofeedback can help reduce sensitivity to light in people who have had a mild traumatic brain injury, also known as a concussion, at least 6 months ago.
Boston, MassachusettsAges 18–65 - NCT06127459Recruiting
Virtual reality to help kids with brain injury improve thinking skills
This trial tests if virtual reality exercises can help children aged 8-12 with mild or moderate traumatic brain injury improve their attention and thinking skills. It is designed for children whose challenges were confirmed by a psychologist and who speak Finnish.
OuluAges 8–12 - NCT06146062RecruitingPhase 2
Stem cell therapy for severe traumatic brain injury
This trial tests whether a single infusion of stem cells from donated umbilical cord tissue can help calm inflammation in the brain after severe traumatic brain injury. It is for patients aged 18–50 who need brain pressure monitoring and are not responding to verbal commands 5 days after sedation is stopped.
ClamartAges 18–50 - NCT06150196Recruiting
Brain health classes for veterans with TBI
This trial tests whether brain health and wellness classes can help veterans who have had multiple mild traumatic brain injuries and also have PTSD. The classes aim to improve cognitive symptoms like memory and attention.
Martinez, CaliforniaAges 18–75 - NCT06162091Recruiting
Understanding recovery after severe brain injury
This study is for adults who recently had a severe brain injury (within the last 3 months) and are in the early stages of recovery. Researchers want to learn more about what affects recovery and how to improve outcomes.
MessinaAges 18 years+ - NCT06177509Recruiting
Exercise therapy for mild traumatic brain injury
This trial tests if graded aerobic exercise can help people who have ongoing symptoms after a mild traumatic brain injury (concussion). It aims to see if carefully increasing exercise intensity improves tolerance to physical activity.
NesoddtangenAges 18–60 - NCT06184295Recruiting
Robotic balance training for better balance after brain injury
This study tests whether training on a robotic device can help improve balance and posture for people who had a traumatic brain injury (TBI) within the last 6 months to 5 years. It may help if you have some balance issues and can stand without support for 5 minutes.
West Orange, New JerseyAges 18–65 - NCT06188364RecruitingEarly Phase 1
Helping caregivers of traumatic brain injury patients
This trial tests if mobile health support (texts and calls) helps caregivers of people with traumatic brain injury after rehab. You may join as the main caregiver if you supervise daily care and have a smartphone or can get one.
Richmond, VirginiaAges 18 years+ - NCT06217575Recruiting
Brain training and stimulation study for veterans with mild TBI
This study tests whether a computer-based brain training program, combined with a non-invasive brain stimulation technique, can help improve thinking speed and memory in veterans who have had a mild traumatic brain injury. It aims to find new ways to support cognitive recovery.
Birmingham, AlabamaAges 50–85 - NCT06241482Recruiting
Enhanced recovery after brain surgery in intensive care
This study tests a special recovery program for people with serious brain injuries or strokes who need intensive care. The program focuses on helping you heal faster after surgery.
ShanghaiAges 18–75 - NCT06282965RecruitingPhase 1/Phase 2
Angiotensin (1-7) for moderate to severe brain injury
This study tests a drug called Angiotensin (1-7) to see if it helps people recover from moderate to severe traumatic brain injury. It may reduce damage and improve healing when given shortly after the injury.
Tucson, ArizonaAges 18 years+ - NCT06333990RecruitingPhase 3
Quetiapine for concussion symptoms in veterans
This study tests whether quetiapine (a medication that can help with mood, sleep, and thinking) reduces ongoing concussion symptoms in veterans who had a mild traumatic brain injury (mTBI) at least 6 months ago. You may join if you are already taking at least three medications for your brain or mental health symptoms and have some PTSD symptoms.
Albuquerque, New MexicoAges 18–65 - NCT06370520Recruiting
Teen emotions screening after mild brain injury
This study screens teens aged 11 to 17 for emotional and mental health problems after a mild traumatic brain injury (mTBI, also called concussion or minor head injury). The goal is to find out if the hospital screening helps identify teens who may need extra support.
Sacramento, CaliforniaAges 11–17 - NCT06413173Recruiting
Remote brain stimulation for attention after mild TBI
This trial tests if a remote brain stimulation device can improve attention and concentration in active-duty service members who have had a mild traumatic brain injury. Participants use the device at home while completing tasks to help with daily focus.
San Diego, CaliforniaAges 18–60 - NCT06469983Recruiting
Robotic vs. traditional standing therapy for severe brain injury
This trial compares using a robotic device versus standard therapy to help people with severe brain injury practice standing. It tests whether the robotic approach leads to better recovery of standing ability.
Sant'Angelo dei Lombardi, AvellinoAges 18–75 - NCT06839079Recruiting
Brain training for trauma survivors with head injury
This study tests a cognitive rehabilitation program for people with traumatic brain injury who have also experienced war, violence, or other trauma. It aims to improve memory and thinking skills using exercises and strategies.
Boston, MassachusettsAges 18–65 - NCT04867317RecruitingPhase 3
Growth hormone treatment for veterans with mild TBI and deficiency
This Phase 3 study tests whether replacing growth hormone in veterans with mild traumatic brain injury (mTBI) and low adult growth hormone can improve quality of life. If you qualify, you’ll be screened with hormone blood tests and memory/mental health checks before starting treatment.
Birmingham, AlabamaAges 21–55 - NCT06544408Recruiting
Brain stimulation for fast relief of PTSD
This study tests a rapid, non-invasive brain stimulation treatment to reduce PTSD symptoms. It aims to offer a faster way to help adults with PTSD feel better.
Tallahassee, FloridaAges 18–65 - NCT06551987Recruiting
Insomnia treatment for military members with mild brain injury
This study tests a behavioral insomnia therapy for active-duty service members who have had a mild traumatic brain injury and continue to have sleep problems and other symptoms. It aims to help improve sleep and recovery.
Fort Cavazos, TexasAges 18–45 - NCT06560372Recruiting
Bleeding after head injury and brain blood vessel narrowing
This study looks at whether moderate to severe traumatic brain injury with bleeding around the brain can lead to a complication called cerebral vasospasm (narrowing of brain blood vessels). It's being done at Martinique University Hospital to understand how often this happens and how it affects recovery.
Fort-de-FranceAges 18 years+ - NCT06561100Recruiting
Optimizing treatment for brain-injured warfighters
This trial tests ways to improve treatment for active-duty service members who have had a mild traumatic brain injury (mTBI) and still have symptoms. It aims to find the best approach to help them recover.
Camp Pendleton, CaliforniaAges 18–55 - NCT06571032Recruiting
EEG guidance for brain stimulation after severe injury
This study tests whether using brain wave monitoring (EEG) can help guide electrical stimulation treatment for people with severe traumatic brain injury. It aims to see if this approach can improve recovery.
Shanghai, Shanghai MunicipalityAges 18 years+
Hear when a new Severe Traumatic Brain Injury trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 227 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.