Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 234 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06480838Recruiting
Brain blood flow and thinking after traumatic brain injury
This study looks at how the brain controls its own blood flow after a moderate to severe traumatic brain injury (TBI). It uses MRI scans and thinking tests to understand recovery and help improve care for people like you.
Dallas, TexasAges 18–80 - NCT06469983Recruiting
Robotic vs. traditional standing therapy for severe brain injury
This trial compares using a robotic device versus standard therapy to help people with severe brain injury practice standing. It tests whether the robotic approach leads to better recovery of standing ability.
Sant'Angelo dei Lombardi, AvellinoAges 18–75 - NCT03321370Recruiting
Study of brain swelling after severe head injury surgery
This trial looks at changes in brain activity after severe traumatic brain injury (TBI) when patients need emergency skull surgery. The goal is to better understand what happens in the brain after surgery and whether earlier recognition could help care after injury.
Minneapolis, MinnesotaAges 18 years+ - NCT06413173Recruiting
Remote brain stimulation for attention after mild TBI
This trial tests if a remote brain stimulation device can improve attention and concentration in active-duty service members who have had a mild traumatic brain injury. Participants use the device at home while completing tasks to help with daily focus.
San Diego, CaliforniaAges 18–60 - NCT06370520Recruiting
Teen emotions screening after mild brain injury
This study screens teens aged 11 to 17 for emotional and mental health problems after a mild traumatic brain injury (mTBI, also called concussion or minor head injury). The goal is to find out if the hospital screening helps identify teens who may need extra support.
Sacramento, CaliforniaAges 11–17 - NCT06282965RecruitingPhase 1/Phase 2
Angiotensin (1-7) for moderate to severe brain injury
This study tests a drug called Angiotensin (1-7) to see if it helps people recover from moderate to severe traumatic brain injury. It may reduce damage and improve healing when given shortly after the injury.
Tucson, ArizonaAges 18 years+ - NCT06188364RecruitingEarly Phase 1
Helping caregivers of traumatic brain injury patients
This trial tests if mobile health support (texts and calls) helps caregivers of people with traumatic brain injury after rehab. You may join as the main caregiver if you supervise daily care and have a smartphone or can get one.
Richmond, VirginiaAges 18 years+ - NCT06109909Recruiting
Brain training for light sensitivity after mild head injury
This study tests if a type of brain training called neurofeedback can help reduce sensitivity to light in people who have had a mild traumatic brain injury, also known as a concussion, at least 6 months ago.
Boston, MassachusettsAges 18–65 - NCT06065046RecruitingPhase 2
Baricitinib for traumatic brain bleeding
This trial tests if baricitinib, an anti-inflammatory drug, can help people with bleeding in the brain from a head injury. It is for adults with moderate to severe traumatic brain injury who are not immediately having surgery.
Xi'an, ShaanxiAges 18–80 - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT06062888RecruitingPhase 2/Phase 3
Testing fresh frozen plasma for traumatic brain injury
This trial tests whether giving fresh frozen plasma (a blood product) soon after a traumatic brain injury can help people recover better. It is for adults aged 18 to 65 with moderate to severe TBI confirmed by CT scan.
Chicago, IllinoisAges 18–65 - NCT06024122Recruiting
Brain development after mild concussion in young children
This study looks at how a mild concussion affects brain development in young children (ages 3–5) compared to kids with other minor injuries like a broken arm. It involves one MRI scan and some simple check-ups to see how the brain heals over time.
RennesAges 3 years–5.9 years - NCT05929833Enrolling by invitation
Brain injury education program for recovery at home
This study tests a recovery-focused brain injury education and support program for people with traumatic brain injury (TBI) who plan to go home after hospital stay. If you qualify, you and a caregiver/friend may get training and therapy support aimed at improving recovery.
Durham, North CarolinaAges 18 years+ - NCT05889650Recruiting
External drainage for severe TBI brain swelling
This study tests whether placing an external drainage tube in the lower back can reduce dangerous pressure in the brain after a severe traumatic brain injury. If you meet safety and brain-scan criteria, it may help the research team understand whether this approach is safe early after injury.
Gainesville, FloridaAges 18–65 - NCT05848297Recruiting
Robotic ultrasound monitoring for severe traumatic brain injury
This trial tests whether a robotic system using a bedside ultrasound test (TCD) can safely monitor brain blood flow in adults with severe traumatic brain injury soon after the injury. It may help the care team track changes earlier and adjust treatment sooner.
Davis, CaliforniaAges 18 years+ - NCT05819008Recruiting
Online brain testing for people with neurological conditions
This trial studies how well a remote, online memory and thinking assessment works for people with neurological disorders or injuries. You may be invited if you can do the computer-based testing and speak Swedish.
UmeåAges 18 years+ - NCT05825027Recruiting
Sorting out risk in children with a recent concussion
This study looks at how to identify which children are at higher risk after a concussion and how they should be monitored. It may help doctors choose safer, more personalized follow-up care after a recent head injury.
Durham, North CarolinaAges 11–17 - NCT05762796Recruiting
Brain scan and stimulation study for kids with mild concussion
This study tests whether a brain “stimulation” approach, paired with brain imaging (MRI), can help children who still have symptoms after a mild concussion. There is also a comparison group of children without concussion history.
Buffalo, New YorkAges 10–15 - NCT05741411Recruiting
Text-and-phone support after concussion for teens
This study tests whether a phone-based (mHealth) handoff and follow-up can help teens after a concussion, especially those at higher risk of long-lasting symptoms. It uses smartphone check-ins and coordination between emergency and specialty care.
Philadelphia, PennsylvaniaAges 13–18 - NCT05725993Recruiting
Study of tiny blood-vessel brain injury after head trauma
This study follows people with a moderate, non-penetrating traumatic brain injury (TBI) to see how small blood-vessel damage changes over time. It uses brain scans to learn what happens after a serious accident, which may help improve future care.
Philadelphia, PennsylvaniaAges 18–65 - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05647044RecruitingPhase 1
Brain stimulation to reduce impulsivity and suicidal thoughts after mild TBI
This early-stage study tests whether a noninvasive brain stimulation treatment (called iTBS) can reduce impulsivity and suicidal thoughts in Veterans who have had a mild traumatic brain injury (mTBI) and recent suicidal thinking. If you qualify, you may be offered a monitored treatment plan and assessments for safety and symptom changes.
Hines, IllinoisAges 22–65 - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 234 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.