Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 234 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07732374RecruitingPhase 2
Long-term results after hyperbaric oxygen therapy in veterans
This study follows veterans who previously finished a 40-session hyperbaric oxygen therapy (HBOT) program. It tracks how their memory, mood, and daily function are doing 12 weeks later, to understand long-term benefits.
Boise, IdahoAges 18 years+ - NCT07774715Recruiting
Electrical stimulation for hand and writing skills after brain injury
This study tests whether electrical stimulation can help improve hand and writing skills after a stroke or brain injury. If it works, it may help you regain better control of your hand movements.
Dallas, TexasAges 18–75 - NCT06147999Recruiting
Biophoton therapy for brain disorders
This trial tests a biophoton therapy, a light-based treatment, for people with brain disorders. It aims to see if this non-invasive approach can help improve symptoms.
Butler, PennsylvaniaAges 18 years+ - NCT02920788Recruiting
Rehab program study for mild traumatic brain injury symptoms
This trial studies whether a specific rehabilitation program (“GOALS”) helps veterans with mild traumatic brain injury (TBI) who still have thinking or memory problems. It compares the program to usual care, using regular assessments and training over time.
San Francisco, CaliforniaAges 18 years+ - NCT07169370Recruiting
Exercise program for chronic brain injury survivors
This trial tests a 12-week exercise platform designed for people with chronic brain injury. It aims to help you become more active safely at home.
Columbus, OhioAges 18 years+ - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT06859996Recruiting
Cognitive rehab study for memory and focus after mild brain injury
This study tests two different types of cognitive rehabilitation (education and problem-solving strategies) delivered via video appointments. It may help people with ongoing thinking and memory problems after a mild brain injury.
Seattle, WashingtonAges 18 years+ - NCT05423860Recruiting
HALO prostate study for men with early prostate cancer
This trial studies HALO, a new “human analytics” approach, in men with early-stage prostate cancer. It may help doctors better assess or guide care using MRI and biopsy findings, before or around initial treatment.
Indian Wells, CaliforniaAges 45–90 - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT07849465RecruitingPhase 2
Oxygen therapy for veterans with brain injury and lasting symptoms
This study tests whether breathing high-pressure oxygen (hyperbaric oxygen therapy) can help veterans who have had a traumatic brain injury (TBI) and are dealing with ongoing issues like memory or concentration problems. It also looks at whether this treatment affects certain markers in the blood that may relate to brain health.
Boise, IdahoAges 18–75 - NCT06311604Recruiting
Inhaled sedation safety for head trauma patients
This trial tests a new way to give sedation through a breathing mask (isoflurane gas) to people with severe head injuries. It aims to see if this method is safe and may help when IV sedatives alone are not enough.
Grenoble, Choisir Une RégionAges 18 years+ - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT07624825Recruiting
Emotional Awareness Therapy After Brain Injury
This study tests whether a therapy focused on recognizing and understanding emotions can help people recover better after a moderate or severe traumatic brain injury (TBI). You'll participate if you're at least 6 months past your injury and struggle to identify or describe your feelings.
Edison, New JerseyAges 18 years+ - NCT07625098RecruitingPhase 1
Social Support Program for People After Brain Injury
This study tests whether a program that helps connect people with social support can improve quality of life for adults living at home after a traumatic brain injury. You might qualify if your injury happened more than 6 months ago and you feel isolated or lack strong social connections.
St Louis, MissouriAges 18 years+ - NCT06473987Recruiting
Virtual reality training for better walking after brain injury
This trial tests a virtual reality program that combines thinking and walking exercises to help improve your balance and walking speed. It may be a good fit if you have a traumatic brain injury and walk more slowly than usual.
West Orange, New JerseyAges 18–65 - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT07549997RecruitingPhase 1
Social Participation Recovery Program After Brain Injury
This study tests whether a group program can help people who've had a traumatic brain injury (TBI) get back to social activities they enjoyed before their injury. You'll work with others and learn strategies to re-engage with friends, family, and community.
St Louis, MissouriAges 18 years+ - NCT07493096Recruiting
Intensive therapy program for children with brain-based conditions
This trial tests an intensive therapy program designed to help children with brain-based conditions like cerebral palsy or autism improve their skills in movement, thinking, and daily activities. The program runs for 2 weeks with daily sessions, and researchers will check for changes in your child's abilities.
The Woodlands, TexasAges 4–12 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT07466589Recruiting
Electric stimulation for dizziness after concussion
This trial tests if a portable electric stimulation device can help improve balance and reduce dizziness in people recovering from a concussion. If you have had ongoing imbalance for at least 4-6 weeks, this study may help you feel steadier.
Ann Arbor, MichiganAges 18–55 - NCT06792877Recruiting
Mindfulness for thinking in early Alzheimer's
This study tests if mindfulness training can help protect thinking and memory in early-stage Alzheimer's disease. It compares mindfulness to other activities to see if it slows down memory loss.
Boston, MassachusettsAges 50–100 - NCT07456020Recruiting
Measuring awareness after brain injury in the ICU
This study checks how awake and aware you are using two standard checklists (CRS-R and SECONDs). It's for people with recent brain injuries in intensive care who are still very dependent.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT07332299Recruiting
Brain stimulation and training for seniors with TBI
This study tests if a wearable brain stimulation device (tDCS) combined with computer-based training can improve attention and concentration in older veterans with a history of mild brain injury. It involves several sessions from home using a headset and computer.
Minneapolis, MinnesotaAges 65 years+
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 234 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.