Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06465290Recruiting
Brain recovery treatment for recent stroke with ankle stiffness
This trial tests a treatment to help your brain recover after a stroke. It focuses on improving ankle movement and leg strength using exercises that promote brain rewiring.
Baltimore, MarylandAges 30–85 - NCT04442971Recruiting
Music therapy for consciousness recovery after brain injury
This trial studies whether music therapy can help improve the level of consciousness in people recovering from a traumatic brain injury. If you are in early neurological rehabilitation, it may be offered as an add-on approach to support recovery.
Hessisch OldendorfAges 18–85 - NCT04445649Recruiting
Find factors to help people regain consciousness after brain injury
This study looks at what predicts recovery of consciousness after certain serious brain injuries, such as stroke or traumatic brain injury. It may help clinicians better identify which patients are more likely to wake up and guide early rehabilitation and care.
Hessisch OldendorfAges 18–85 - NCT04610697Recruiting
Cognitive training for people in forensic mental health care
This trial studies whether a structured “cognitive remediation” program (training thinking skills) can help people receiving care on a forensic treatment unit. It may benefit those who want support improving attention, memory, or problem-solving as part of their treatment.
Ottawa, OntarioAges 18–55 - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT05423860Recruiting
HALO prostate study for men with early prostate cancer
This trial studies HALO, a new “human analytics” approach, in men with early-stage prostate cancer. It may help doctors better assess or guide care using MRI and biopsy findings, before or around initial treatment.
Indian Wells, CaliforniaAges 45–90 - NCT05426967Recruiting
Brain stimulation for depression after mild traumatic brain injury
This trial studies a noninvasive brain treatment (rTMS) to reduce depression symptoms in people with past mild traumatic brain injury from military service. It may help by changing brain activity, while also requiring stable mental health care and regular follow-up.
Palo Alto, CaliforniaAges 18–55 - NCT05589064Recruiting
Diet and nutrition program for lingering concussion symptoms
This study tests whether a dietary and nutrition intervention can improve symptoms that linger after a concussion. It may help people whose post-concussion symptoms have lasted a short to medium time (at least 2 weeks).
Moncton, New BrunswickAges 16 years+ - NCT05683145Recruiting
Better sleep for people with moderate or severe TBI
This trial studies an approach to improve insomnia (trouble falling or staying asleep) in people who had a moderate-to-severe traumatic brain injury at least one year ago. If you qualify, it may help you restore more regular, efficient sleep after TBI.
Aurora, ColoradoAges 18–60 - NCT05782244RecruitingPhase 2
Sildenafil trial for long-term brain blood-flow problems after TBI
This Phase 2 study tests whether sildenafil (a medication better known for erectile function) can improve long-term symptoms and brain blood-flow issues after a past traumatic brain injury (TBI). It may help by improving blood vessel function in the brain and possibly reducing persistent post-concussion symptoms.
Philadelphia, PennsylvaniaAges 18–70 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT06028334Recruiting
GetUp&Go: Helping you get active after a brain injury
This study tests a program to help people with traumatic brain injury become more physically active. You would use a smartphone app and get coaching to increase your daily movement, which may improve your recovery and quality of life.
Elkins Park, PennsylvaniaAges 18 years+ - NCT06034509Recruiting
Thinking and blood vessel health after head injury
This study looks at how a past traumatic brain injury (TBI) might affect your thinking skills and blood vessel health over time. You may be eligible if you had a TBI at least 3 years ago and have already completed an earlier evaluation at the National Intrepid Center of Excellence (NICoE).
Bethesda, MarylandAges 18–74 - NCT06073106Recruiting
Frailty prevention study for older Asian adults
This trial tests a program to prevent frailty in people aged 50 and older of Asian descent who have recently been diagnosed with a stroke, traumatic brain injury, knee osteoarthritis, or breast cancer. The goal is to help you stay strong and healthy as you recover.
Singapore, SingaporeAges 50 years+ - NCT06148324Recruiting
Wellness program for traumatic brain injury recovery
This study tests a wellness program for people who had a moderate or severe traumatic brain injury (TBI) at least a year ago. The program is done online, so you can join from home, and it aims to help you with your recovery and well-being.
New York, New YorkAges 18–70 - NCT06222450Recruiting
Vestibular rehab app for dizziness after mild brain injury
This study tests a smartphone app with exercises to help improve balance and dizziness in people who have had a mild traumatic brain injury. You may be eligible if you are still experiencing dizziness or balance problems.
Tampa, FloridaAges 18 years+ - NCT06292585Recruiting
Blocking the artery to treat epidural hematoma
This trial tests a new way to treat a blood clot outside the brain (epidural hematoma) after a head injury. Instead of surgery, doctors use a thin tube to block the artery feeding the clot, which may help the body absorb the clot more safely.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06311604Recruiting
Inhaled sedation safety for head trauma patients
This trial tests a new way to give sedation through a breathing mask (isoflurane gas) to people with severe head injuries. It aims to see if this method is safe and may help when IV sedatives alone are not enough.
Grenoble, Choisir Une RégionAges 18 years+ - NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT06473987Recruiting
Virtual reality training for better walking after brain injury
This trial tests a virtual reality program that combines thinking and walking exercises to help improve your balance and walking speed. It may be a good fit if you have a traumatic brain injury and walk more slowly than usual.
West Orange, New JerseyAges 18–65 - NCT07694258Recruiting
Testing a helmet for brain stimulation in consciousness disorders
This study tests a special helmet that uses ultrasound to stimulate the brain in people with disorders of consciousness caused by brain injury. It aims to see if the treatment is safe and possible to do.
Toronto, OntarioAges Any age - NCT06494319Recruiting
PTSD treatment app for veterans with combat trauma
This study tests a virtual training program and mobile app to help veterans manage PTSD from combat. It aims to reduce symptoms and improve daily life.
Houston, TexasAges 18–79 - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 226 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.