Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07625995RecruitingPhase 2
Fluid management strategies for traumatic brain injury patients
This study tests two different approaches to managing fluids given to brain injury patients in the ICU—one more restrictive and one more liberal—to see which is safer and more effective. The goal is to find the best balance that protects the brain while supporting overall health.
BrusselsAges 18 years+ - NCT07635329Recruiting
Home Vision Therapy Guided by Brain Scans
This study tests whether vision rehabilitation exercises done at home, guided by brain imaging, can help people regain vision after a stroke, brain injury, or tumor. Participants will use brain scans to personalize their therapy.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07655310Recruiting
Parent factors and CT use in kids with minor head injury
This study looks at how a parent's background and understanding of health information might affect whether a child with a minor head injury gets a CT scan. It aims to better understand these factors to improve care.
BursaAges Up to 17 years - NCT07463027Enrolling by invitation
Veteran brain injury rehab with integrated care
This trial tests a 3-week rehabilitation program for veterans with traumatic brain injury and other conditions. It aims to improve recovery through team-based care.
Milwaukee, WisconsinAges 18–65 - NCT06901310Enrolling by invitation
Hyperbaric oxygen for mild head injuries in combat athletes
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a special chamber) helps men recover from mild head injuries better than the current standard care (rest). It is for male unarmed combat athletes who have been suspended for a head injury.
Marshfield, WisconsinAges 18 years+ - NCT06817837Enrolling by invitation
Can hypnosis help adults with brain injury?
This study tests if hypnosis can help adults with stroke or traumatic brain injury who have symptoms like anxiety, trouble sleeping, pain, or behavior issues. Researchers want to see if it's a feasible and useful addition to usual care.
Tinlot, LiègeAges 18 years+ - NCT05929833Enrolling by invitation
Brain injury education program for recovery at home
This study tests a recovery-focused brain injury education and support program for people with traumatic brain injury (TBI) who plan to go home after hospital stay. If you qualify, you and a caregiver/friend may get training and therapy support aimed at improving recovery.
Durham, North CarolinaAges 18 years+ - NCT05616910Enrolling by invitationPhase 2
Inhaled nitric oxide for microvascular problems after brain injury
This Phase 2 study tests whether inhaled nitric oxide can improve tiny blood-flow problems in the brain after traumatic brain injury. If you qualify, you may receive inhaled nitric oxide and be monitored for safety and recovery.
Philadelphia, PennsylvaniaAges 18–75 - NCT04982731Enrolling by invitation
Testing reassurance support after a concussion in teens
This study looks at whether a specific reassurance program (“Positive Assurance”) helps teens recover better after a mild concussion. Teens are checked for concussion symptoms, then assigned to different support approaches to see which helps most.
Falls Church, VirginiaAges 13–21 - NCT03502967Enrolling by invitationEarly Phase 1
Hyperpolarized carbon-13 brain scan for recent traumatic brain injury
This early study tests a special brain imaging scan that looks at brain metabolism after a recent concussion/traumatic brain injury (TBI). It may help researchers understand what’s happening in the brain soon after injury.
Dallas, TexasAges 18–60 - NCT07732868Enrolling by invitation
Virtual Reality Therapy for Spinal Cord Injury
This trial tests a virtual reality (VR) program that uses brain-machine interface (BMI) technology to help people with spinal cord injuries regain movement. The program may help your brain and body work together better, potentially improving your recovery.
AveiroAges 18–65 - NCT07215195Recruiting
Brain injury, sleep, and mental health study
This study looks at how brain injuries affect sleep and mental health in the months after injury. It is for people who have had a stroke, brain bleed, or traumatic brain injury within the past year and are willing to let the research team contact their doctor if needed.
OxfordAges 18 years+ - NCT07345481Recruiting
Learning new connections in brain injury
This study tests whether people with an acquired brain injury can learn new connections between symbols and words using a computer-based learning method. The goal is to see if this approach can help with cognitive rehabilitation.
Arnhem, GelderlandAges 18–75 - NCT06800040Enrolling by invitation
Group memory training for brain injury survivors
This trial tests a group memory training program for people who have had a brain injury at least 6 months ago and still have memory problems. The training is in Norwegian and aims to help improve memory skills.
TromsøAges 18–75 - NCT05863897Enrolling by invitation
Online program to help long-term fatigue after brain injury
This trial tests an online, blended coaching program for severe fatigue that lasts at least 6 months after a stroke or traumatic brain injury. It may help reduce fatigue by supporting self-management using an internet-based approach.
Wijk aan Zee, North HollandAges 18–70 - NCT07732374RecruitingPhase 2
Long-term results after hyperbaric oxygen therapy in veterans
This study follows veterans who previously finished a 40-session hyperbaric oxygen therapy (HBOT) program. It tracks how their memory, mood, and daily function are doing 12 weeks later, to understand long-term benefits.
Boise, IdahoAges 18 years+ - NCT06147999Recruiting
Biophoton therapy for brain disorders
This trial tests a biophoton therapy, a light-based treatment, for people with brain disorders. It aims to see if this non-invasive approach can help improve symptoms.
Butler, PennsylvaniaAges 18 years+ - NCT02920788Recruiting
Rehab program study for mild traumatic brain injury symptoms
This trial studies whether a specific rehabilitation program (“GOALS”) helps veterans with mild traumatic brain injury (TBI) who still have thinking or memory problems. It compares the program to usual care, using regular assessments and training over time.
San Francisco, CaliforniaAges 18 years+ - NCT07169370Recruiting
Exercise program for chronic brain injury survivors
This trial tests a 12-week exercise platform designed for people with chronic brain injury. It aims to help you become more active safely at home.
Columbus, OhioAges 18 years+ - NCT06860828Enrolling by invitation
Football players and brain health study: DIAGNOSE CTE
This study looks at brain changes in former college and professional football players, people with memory problems, and healthy controls. It aims to learn more about chronic traumatic encephalopathy (CTE) and Alzheimer's disease.
Phoenix, ArizonaAges 50 years+ - NCT06859996Recruiting
Cognitive rehab study for memory and focus after mild brain injury
This study tests two different types of cognitive rehabilitation (education and problem-solving strategies) delivered via video appointments. It may help people with ongoing thinking and memory problems after a mild brain injury.
Seattle, WashingtonAges 18 years+ - NCT05115929Recruiting
Surgery for dangerously high pressure after head injury
This trial compares two emergency surgery approaches for people with traumatic brain injury who have dangerously high pressure inside the skull that does not improve with standard treatments. The goal is to see which approach leads to better long-term outcomes.
ClamartAges 18–65 - NCT06909071Recruiting
Smart insulin pump for blood sugar control after brain surgery
This trial tests a smart insulin pump (hybrid closed-loop system) to control high blood sugar after brain surgery for bleeding strokes. It's for people with type 2 diabetes who are stable enough to leave the intensive care unit and are getting tube feedings.
Taiyuan, ShanxiAges 18–75 - NCT06790095Enrolling by invitationPhase 2
Testing Cyclosporine for Moderate to Severe Brain Injury
This study tests a drug called cyclosporine to see if it can help people with moderate to severe traumatic brain injury. You may be eligible if you have a brain injury seen on CT and can start treatment within 24 hours.
San Francisco, CaliforniaAges 18–65
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 226 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.