Clinical trials
Severe Traumatic Brain Injury clinical trials
Below are recruiting severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 234 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07319208RecruitingPhase 3
Testing a continuous infusion of a treatment for traumatic brain injury
This trial tests whether starting a continuous infusion of a concentrated salt solution (HSS) early in the ICU can improve brain recovery at 6 months in patients with traumatic brain injury. It may help control brain swelling and pressure.
AngersAges 18–75 - NCT07301710RecruitingPhase 1/Phase 2
Low-tech treatments for sleep apnea
This study tests simple, low-tech treatments (like exercises) for sleep apnea. It's for people who are newly diagnosed or whose current treatment isn't working, and who are willing to pause their usual treatment for 3 months.
Bethesda, MarylandAges 18–65 - NCT07282691Recruiting
Validating eye tests for mild brain injury
This study looks at eye tests for people who had a mild brain injury (mTBI) in the last 1 to 6 months. It aims to better understand and measure eye movement problems that can happen after such an injury.
Philadelphia, PennsylvaniaAges 18–35 - NCT06028334Recruiting
GetUp&Go: Helping you get active after a brain injury
This study tests a program to help people with traumatic brain injury become more physically active. You would use a smartphone app and get coaching to increase your daily movement, which may improve your recovery and quality of life.
Elkins Park, PennsylvaniaAges 18 years+ - NCT06589362Recruiting
Nerve stimulation plus cognitive training for brain injury recovery
This study tests if a gentle, noninvasive nerve stimulation (on the neck) combined with computerized thinking exercises can help people recovering from a traumatic brain injury improve memory and attention. It is for adults currently in inpatient rehab who can use a keyboard and are medically stable.
Chicago, IllinoisAges 18–65 - NCT06292585Recruiting
Blocking the artery to treat epidural hematoma
This trial tests a new way to treat a blood clot outside the brain (epidural hematoma) after a head injury. Instead of surgery, doctors use a thin tube to block the artery feeding the clot, which may help the body absorb the clot more safely.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07202494Recruiting
Brain aging and resilience MRI study
This study uses powerful MRI scans to understand how the brain ages and why some people stay healthy while others develop neurological diseases like multiple sclerosis or Alzheimer's. It compares healthy volunteers to people with certain conditions, and all participants get a detailed brain MRI.
MarseilleAges 18–90 - NCT06909071Recruiting
Smart insulin pump for blood sugar control after brain surgery
This trial tests a smart insulin pump (hybrid closed-loop system) to control high blood sugar after brain surgery for bleeding strokes. It's for people with type 2 diabetes who are stable enough to leave the intensive care unit and are getting tube feedings.
Taiyuan, ShanxiAges 18–75 - NCT07176936Recruiting
Can ear stimulation improve hearing in noise?
This study tests whether a gentle, noninvasive ear stimulation device can help people hear speech better in noisy places. It is for people who have had a traumatic brain injury or those with normal hearing.
Gainesville, FloridaAges 25–55 - NCT07120373Recruiting
Sleep after traumatic brain injury: a wearable tracker study
This study looks at how sleep is affected after a traumatic brain injury (TBI). It uses a small wearable tracker to measure sleep patterns at home, either soon after the injury or a year or more later.
Nottingham, NottinghamshireAges 18–60 - NCT06562127Recruiting
Water exercise and cognitive training for veterans with TBI
This trial tests if combining water-based exercise with cognitive training over eight months can help improve thinking and memory in veterans with a past mild or moderate brain injury. It may benefit veterans aged 50-89 who have ongoing cognitive complaints.
Palo Alto, CaliforniaAges 50–89 - NCT07055633Recruiting
Improving cognitive rehab for veterans with concussion and PTSD
This trial tests a program to help veterans with memory, attention, or thinking problems after a mild concussion (mTBI) and with PTSD. It also looks at depression and sleep issues. The goal is to improve thinking and daily life.
San Diego, CaliforniaAges 18 years+ - NCT07044596Recruiting
Non-invasive brain stimulation to slow cognitive decline
This study tests whether a gentle, non-invasive electrical stimulation can help slow memory loss or thinking problems. It is looking for healthy volunteers and people who have had a mild traumatic brain injury within the past year.
Madison, WisconsinAges 20–85 - NCT06973018Enrolling by invitation
Online cognitive rehab for mild memory problems
This trial tests an online program to help people with mild to moderate cognitive problems after a brain injury or nervous system disease improve their thinking skills. It is for Swedish speakers with internet access.
Stockholm, Stockholm CountyAges 18 years+ - NCT06920784Recruiting
Prismatic glasses therapy for brain injury rehabilitation
This trial tests whether wearing special prismatic glasses during cognitive exercises can help people recovering from a traumatic brain injury. It is designed for patients who are still in the early stages of recovery and have a certain level of consciousness and attention.
BariAges 18 years+ - NCT06893029Recruiting
Dizziness from visual motion in concussion and other causes
This study looks at how people with dizziness from concussion or other causes (like vestibular migraine) react to visual motion. It tests balance during specific visual challenges to understand why dizziness happens.
Zurich, Canton of ZurichAges 18–60 - NCT06855186Recruiting
Rehabilitation for concussion based on your symptoms
This study tests a symptom-focused rehabilitation program for people who had a mild traumatic brain injury (concussion) at least 3 months ago. It aims to help with ongoing cognitive complaints like memory or concentration problems.
Wahiawa, HawaiiAges 18–64 - NCT06830291Recruiting
Validating a digital cognitive test for head trauma patients
This study aims to validate a digital cognitive assessment tool (Neuralix) for people who have experienced moderate to severe head trauma within the past 5 years. Participation helps ensure the tool is accurate and useful for monitoring recovery.
ClamartAges 18–65 - NCT06819904Recruiting
Combined talk therapy and balance rehab for mild TBI
This trial tests a new type of therapy that combines acceptance and commitment therapy (a counseling approach) with vestibular rehabilitation (exercises for balance and dizziness). It's designed for people with mild traumatic brain injury who still have symptoms like dizziness, anxiety, or memory problems.
Pittsburgh, PennsylvaniaAges 18–49 - NCT06790095Enrolling by invitationPhase 2
Testing Cyclosporine for Moderate to Severe Brain Injury
This study tests a drug called cyclosporine to see if it can help people with moderate to severe traumatic brain injury. You may be eligible if you have a brain injury seen on CT and can start treatment within 24 hours.
San Francisco, CaliforniaAges 18–65 - NCT06465290Recruiting
Brain recovery treatment for recent stroke with ankle stiffness
This trial tests a treatment to help your brain recover after a stroke. It focuses on improving ankle movement and leg strength using exercises that promote brain rewiring.
Baltimore, MarylandAges 30–85 - NCT06381674Recruiting
Wearable tech for balance rehab after concussion
This study tests whether a wearable device can help people with balance and vision problems after a mild concussion. You will use the device to guide your own exercises and help improve your recovery.
Portland, OregonAges 18–60 - NCT06034509Recruiting
Thinking and blood vessel health after head injury
This study looks at how a past traumatic brain injury (TBI) might affect your thinking skills and blood vessel health over time. You may be eligible if you had a TBI at least 3 years ago and have already completed an earlier evaluation at the National Intrepid Center of Excellence (NICoE).
Bethesda, MarylandAges 18–74 - NCT06222450Recruiting
Vestibular rehab app for dizziness after mild brain injury
This study tests a smartphone app with exercises to help improve balance and dizziness in people who have had a mild traumatic brain injury. You may be eligible if you are still experiencing dizziness or balance problems.
Tampa, FloridaAges 18 years+
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Common questions
- Are there clinical trials for severe traumatic brain injury?
- Yes. Clin2 currently lists 234 recruiting severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.