Clinical trials
Skeletal Muscle clinical trials
Below are recruiting skeletal muscle clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06025500Recruiting
Muscle function before and after lung valve treatment
This study looks at how well your leg muscles work before and after getting special valves placed in your lungs. It uses an exercise bike test and an MRI scan to measure muscle changes, and the results may help people with COPD breathe better.
GroningenAges Any age - NCT05671614Recruiting
Prevent muscle stem cell failure after critical illness
This trial studies ways to improve recovery of skeletal muscle in people who have been very sick in the ICU. It focuses on preventing problems with the body’s muscle “repair cells” after critical illness.
Prague, Czech RepublicAges 18 years+ - NCT06475391Recruiting
L-arginine supplement for exercise performance
This study tests whether taking L-arginine (a natural amino acid supplement) can improve your performance during short, intense exercise like sprinting or weightlifting. If you are a healthy, active adult, you may be able to join.
Winnipeg, ManitobaAges 18–39 - NCT06083766Recruiting
Hormone Therapy Effects on Metabolism in Transgender Adults
This study looks at how long-term gender-affirming hormone therapy affects your body's metabolism and energy use. Researchers want to understand these changes better to improve care for transgender and gender-diverse people.
Rochester, MinnesotaAges 18–40 - NCT06967220Enrolling by invitation
Inflammation's effect on muscle in hospitalized patients
This study tests whether inflammation affects muscle loss in older hospitalized patients who are malnourished. It could help find ways to protect muscle strength during a hospital stay.
CopenhagenAges 65 years+ - NCT06689761Enrolling by invitation
Collagen peptides and exercise: muscle strength study
This trial tests whether taking collagen peptides before exercise can improve how your muscles adapt to strength training. It could help you build muscle more effectively.
Vienna, State of ViennaAges 18–40 - NCT05801185Enrolling by invitation
Studying muscle changes after leg unloading in healthy young adults
This trial looks at how human muscle cells change when one leg is not used for a short time. It may help us understand muscle loss and how to prevent it.
Huddinge, Stockholm CountyAges 18–40 - NCT07251361Enrolling by invitation
Exercise program for heart failure with preserved ejection fraction
This study tests whether a special exercise program that combines different types of training (like aerobic, strength, and balance) can improve heart and muscle function, daily abilities, and quality of life in people with heart failure with preserved ejection fraction (HFpEF). You may benefit if your heart failure is stable and you are able to exercise safely.
Pamplona, NavarreAges 18 years+ - NCT07724522Recruiting
Prebiotic Fiber for Irregular Periods in Women
This study tests whether taking a prebiotic fiber (inulin) can help women who are in the later years of their reproductive life (before menopause) and have irregular periods. You may be eligible if you are overweight, have irregular cycles, sit a lot, and do not exercise much.
Washington D.C., District of ColumbiaAges 40–55 - NCT03584204Recruiting
Imaging study for people with liver cirrhosis
This study looks at how liver cirrhosis shows up on non-invasive imaging like CT scans, and how those findings relate to outcomes. It may help researchers better understand what scan patterns could signal disease severity.
BonnAges 18–80 - NCT03800017Recruiting
Muscle strength and exercise function in lung scarring
This study looks at how well skeletal (muscle) function supports exercise in people with interstitial lung diseases (including idiopathic pulmonary fibrosis). It may help better understand fitness and breathing limits, which can guide rehabilitation choices and future care.
Vancouver, British ColumbiaAges 40–80 - NCT03940911Recruiting
Testing fatigue and muscle effects after starting targeted therapy
This study looks at how starting “targeted” treatment affects fatigue and skeletal muscle function in people with severe axial spondyloarthritis. It may help doctors understand what to expect early after treatment starts and how well it impacts day-to-day energy and muscle performance.
Strasbourg, Bas-RhinAges 18 years+ - NCT04142047Recruiting
Study muscle energy and fatigue in older adults
This study measures how older adults’ muscles use energy and how easily they tire during activity. It includes both people with HIV (with stable treatment and an undetectable viral load) and people without HIV to better understand differences in fatigue.
Baltimore, MarylandAges 60–90 - NCT04449198RecruitingEarly Phase 1
Study for mitochondrial and blood-vessel issues in type 1 diabetes
This early study looks at how a new approach may affect energy-making (mitochondria) and blood-vessel signaling in people with insulin-dependent type 1 diabetes. It may help researchers understand whether these pathways can be improved in type 1 diabetes.
Augusta, GeorgiaAges 18 years+ - NCT05789433Recruiting
Aerobic exercise study after colon or rectal cancer surgery
This trial studies whether a supervised aerobic exercise program helps muscles “remodel” (change/strengthen) after colon or rectal cancer treatment. It may help people improve physical function during recovery, but you can only join if it’s safe for you and you can follow the study plan.
Orlando, FloridaAges 18 years+ - NCT05884138Recruiting
Amino acid supplement and exercise for people on dialysis
This trial studies whether taking essential amino acids along with exercise can improve muscle function in people receiving hemodialysis. It may help you build or maintain strength and mobility.
Daejeon, South KoreaAges 20–80 - NCT05985525Recruiting
Monitoring blood flow in ICU patients with severe infection or shock
This study monitors tiny blood vessels under the tongue using a non-invasive device to see how well blood flows in ICU patients on a breathing machine. Researchers hope to improve care for patients with serious infections or shock.
Winnipeg, ManitobaAges 18 years+ - NCT06009276Recruiting
Gut bacteria, muscle blood flow, and fitness study
This study looks at how the bacteria in your gut affect blood flow to your muscles and your overall fitness. You will provide samples and do some exercise tests to help researchers understand this link.
Charlottesville, VirginiaAges 18 years+ - NCT06053229Recruiting
Massage therapy for leg muscle health during immobilization
This trial examines if percussive massage can help maintain leg muscle mass and strength when your leg is immobilized (e.g., in a cast). It aims to see if this therapy could reduce muscle loss during periods of disuse.
Provo, UtahAges 18–50 - NCT07091500Recruiting
Exercise and a weight-loss drug for people with obesity
This trial tests whether combining a GLP-1 medication (a type of diabetes drug that also helps with weight loss) with an exercise program can improve physical function in people with obesity. If you are obese and have trouble with daily activities, this study may help you become more mobile and healthier.
St Louis, MissouriAges 50–75 - NCT06532474Recruiting
Muscle function study in SMA patients on SMN therapies
This study looks at how muscles work in children and young adults with spinal muscular atrophy (SMA) who are taking or starting SMN-directed therapies (like Evrysdi, Spinraza, or Zolgensma). It aims to understand the body's response to these treatments, which could help improve future care.
Memphis, TennesseeAges 5–20 - NCT07692308Recruiting
Muscle health study for sarcopenia prevention and treatment
This study looks at muscle changes in people with or at risk for sarcopenia (age-related muscle loss). It aims to find better ways to detect and manage sarcopenia using simple tests like muscle strength and body composition measurements.
Milan, MiAges 50 years+ - NCT06486597Recruiting
Metabolism study in children with cerebral palsy
This study looks at how the body uses energy in children with cerebral palsy who have low muscle mass. It compares them to healthy children to understand metabolism better.
Copenhagen, Copenhagen ØAges 2–18 - NCT06573086Recruiting
Resistance training, detraining, and retraining
This study looks at how your body responds to resistance training, a break from training, and then training again. It is for healthy adults who already completed a previous exercise study.
Jyväskylä, Central FinlandAges 18–50
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Common questions
- Are there clinical trials for skeletal muscle?
- Yes. Clin2 currently lists 62 recruiting skeletal muscle studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a skeletal muscle trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a skeletal muscle trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.