Clinical trials
Soft Tissue clinical trials
Below are recruiting soft tissue clinical trials, each written for real people, not researchers. We’re tracking 323 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06114004RecruitingPhase 2
Selinexor plus gemcitabine for advanced soft-tissue sarcoma
This trial tests a combination of two drugs, selinexor and gemcitabine, for people with a type of soft-tissue sarcoma (leiomyosarcoma or malignant peripheral nerve sheath tumor) that has spread or cannot be surgically removed and has gotten worse despite at least one prior treatment. The goal is to see if this combination can help shrink or slow the cancer.
Santa Cruz de Tenerife, Canary IslandsAges 18–80 - NCT06171282RecruitingEarly Phase 1
Virus therapy for advanced bone and soft tissue tumors
This trial tests an investigational virus therapy (R130) injected directly into tumors for people with advanced bone or soft tissue cancer who have exhausted standard treatments or choose not to pursue them.
ShanghaiAges 16–75 - NCT06760221Recruiting
Spotlight on bone cancer: SBRT plus surgery
This trial tests if giving a high dose of focused radiation (SBRT) before surgery can improve outcomes for people with aggressive soft tissue sarcoma in an arm or leg. You may be able to avoid chemotherapy and still have a good result.
Hangzhou, ZhejiangAges 18–80 - NCT06939855RecruitingPhase 2
QL1706 for advanced bone and soft tissue sarcoma
This trial tests an experimental drug called QL1706 for people with advanced sarcoma (a type of cancer that starts in bones or soft tissues like muscle or fat) that cannot be removed by surgery or has spread. The goal is to see if QL1706 can help shrink or control the cancer.
Guangzhou, GuangdongAges 18–75 - NCT06968988RecruitingPhase 1
Three-drug combo for advanced soft tissue sarcoma
This trial tests a new combination of three drugs (zanzalintinib, ipilimumab, and nivolumab) for people with soft tissue sarcoma that has spread. The goal is to see if this combination can shrink or slow the cancer.
St Louis, MissouriAges 18 years+ - NCT07609329Recruiting
Nutritional Support Before Sarcoma Surgery
This study tests whether special nutritional supplements given before surgery for bone or soft tissue sarcoma (a type of cancer) can help your body heal better and recover faster. You'll take oral supplements for at least a week before your planned surgery.
BrnoAges Any age - NCT06743958Enrolling by invitation
Prehab for kids with leg bone or soft tissue sarcomas
This study tests whether a prehabilitation program (special exercises and support before cancer treatment) helps children and teens with leg sarcomas recover better. It aims to improve strength and mobility after treatment.
Munich, BavariaAges 6–18 - NCT07624331Recruiting
PEEK vs. Standard Healing Caps for Tooth Implants
This study compares two types of temporary healing caps (PEEK and standard materials) used during dental implant surgery for a single back tooth. Researchers will measure how well the gum tissue heals around each type to see which works better.
Sungai Buloh, SelangorAges 18 years+ - NCT07409558Recruiting
3D scan study for gum improvement after surgery
This study uses 3D digital scans to measure gum tissue changes after a gum grafting procedure. It may be helpful for people with receding gums on their lower front teeth.
Kahramanmaraş, KahramanmaraşAges 18 years+ - NCT06263231RecruitingPhase 3
Study of INT230-6 injection for soft tissue sarcoma
This study tests an experimental drug, INT230-6, injected directly into tumors, compared to the usual treatments for soft tissue sarcoma. It aims to see if the injection is safe and works better for people whose cancer has not responded to earlier treatments.
Los Angeles, CaliforniaAges 18 years+ - NCT05182164RecruitingPhase 2
Pembrolizumab plus cabozantinib for advanced sarcoma patients
This Phase 2 trial studies whether combining pembrolizumab and cabozantinib can control advanced sarcoma that can’t be removed by surgery and has grown or returned after standard treatment. It may help shrink tumors and improve outcomes in adults who have limited treatment options left.
BordeauxAges 18 years+ - NCT06593899RecruitingPhase 2
Chemotherapy and radiation before surgery for arm or leg sarcoma
This trial tests giving chemotherapy and radiation therapy together before surgery for soft tissue sarcoma in the arms or legs. The goal is to see if this approach can improve outcomes for people with larger, high-grade, or deep tumors.
Fuzhou, FujianAges 18–75 - NCT07291297RecruitingPhase 2
Metformin plus standard therapy for soft tissue sarcoma
This trial tests adding metformin, a common diabetes drug, to the usual first cancer treatment for advanced soft tissue sarcoma. It may help the standard therapy work better.
Charlotte, North CarolinaAges 18 years+ - NCT05839275RecruitingPhase 1/Phase 2
Radiation plus two medicines for high-risk soft tissue sarcoma
This Phase 1/2 trial tests whether combining radiation with two targeted/immune medicines can shrink or control high-risk soft tissue sarcoma and improve outcomes. It may help patients whose tumors are large, hard to fully remove, or have come back after prior treatment.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05774275RecruitingPhase 1/Phase 2
Testing combined radiation, chemotherapy, and immunotherapy for high-risk sarcoma
This study tests whether giving radiation, chemotherapy, and immunotherapy together can control high-risk soft tissue sarcoma that is hard to remove or may come back after surgery. It may help by attacking cancer in different ways, including boosting the immune system.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07734337Enrolling by invitation
Reconstruction surgery for upper body soft tissue defects
This trial tests a surgical technique using a skin flap from the back (called a TDAP flap) to repair defects in the upper body, such as after cancer surgery, injury, or scar release. It may help patients who need reconstructive surgery on the breast, shoulder, chest wall, or armpit.
Sohag, Sohag GovernorateAges 5–75 - NCT03805022RecruitingPhase 3
Extra chemotherapy around surgery for high-risk soft-tissue sarcoma
This trial tests whether giving stronger chemotherapy before and/or after surgery helps people with high-risk, resectable soft-tissue sarcoma. It aims to lower the chance the cancer comes back by improving treatment around the time of the operation.
BordeauxAges 18 years+ - NCT06835049RecruitingPhase 2
Heating therapy before surgery for high-risk soft tissue sarcoma
This trial tests a new approach for high-risk soft tissue sarcoma of the arm, leg, or trunk. Before surgery, you would receive chemotherapy combined with local hyperthermia (a treatment that gently heats the tumor area) to see if this can improve outcomes.
AarauAges 18 years+ - NCT06848582Recruiting
NK cell therapy for high-risk pediatric soft tissue sarcoma
This trial tests whether giving immune cells called NK cells from donated umbilical cord blood can help children and teens with high-risk or returning soft tissue sarcoma. The goal is to see if it is safe and effective when other treatments have been tried.
Guangzhou, GuangdongAges Up to 18 years - NCT02275286RecruitingPhase 1/Phase 2
Trabectedin plus radiation for select soft tissue sarcomas
This trial studies whether adding a chemotherapy medicine called trabectedin to targeted radiation can help control certain soft tissue sarcomas. It focuses on specific cancer types and locations, aiming to shrink tumors while keeping radiation safe for nearby healthy organs.
BordeauxAges 18 years+ - NCT02677961Recruiting
Build a bone and soft tissue tumor health record registry
This registry collects health information from people with bone or soft tissue tumors to help researchers understand these cancers better. You may be able to join if you (or your legal decision-maker) can consent to participate.
Columbus, OhioAges 18 years+ - NCT02701153Recruiting
Short pre-surgery radiation for soft-tissue sarcoma
This trial tests a short course of radiation before surgery to shrink a soft-tissue sarcoma and make it easier to remove. It may help by improving how well the tumor can be removed, while studying safety and effectiveness for this cancer type.
Los Angeles, CaliforniaAges 18 years+ - NCT02789384Recruiting
Study of tumor markers to predict chemotherapy benefit in sarcoma
This study looks at stored tumor tissue (or takes a new biopsy) to measure specific tumor markers. Researchers want to see whether these markers match how well chemotherapy works before surgery for soft-tissue sarcoma.
BordeauxAges 18 years+ - NCT07436364RecruitingEarly Phase 1
Ultrasound to monitor sarcoma response to radiation
This trial uses contrast-enhanced ultrasound to see how well soft tissue sarcoma responds to radiation therapy given before surgery. The goal is to find out if this imaging method can help doctors assess treatment effects earlier.
Philadelphia, PennsylvaniaAges 18 years+
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Common questions
- Are there clinical trials for soft tissue?
- Yes. Clin2 currently lists 323 recruiting soft tissue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a soft tissue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a soft tissue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.