Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 226 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07089251RecruitingPhase 4
Epinephrine and tranexamic acid in knee replacement surgery
This study tests if using epinephrine and tranexamic acid together helps reduce bleeding and improve outcomes during knee replacement surgery. It may be a good fit if you are planning to have knee replacement and do not have certain medical conditions or allergies to these medicines.
Riyadh, Riyadh RegionAges 18–70 - NCT07092982Recruiting
Comparing two numbing methods for knee replacement surgery
This study compares two different numbing techniques to see which provides better pain control during and after total knee replacement. It may help find a way to reduce pain and improve recovery.
IstanbulAges 18–75 - NCT07080814Recruiting
Balance exercises after knee replacement
This study tests whether special balance exercises on a platform can help people who have recently had a knee replacement walk better and feel steadier.
Ankara, YenimahalleAges 18 years+ - NCT07080892Recruiting
Comparing two ways to give a knee nerve block for pain after knee replacement
This study compares two different ways of giving a nerve block (called iPACK) to see which works better for pain after total knee replacement. The goal is to find the best spot for the injection to help you feel more comfortable after surgery.
BratislavaAges 18–80 - NCT06640491RecruitingPhase 1/Phase 2
Antibiotics via bone injection for knee replacement
This study tests giving antibiotics (cefazolin and vancomycin) through a small needle into the shin bone during knee replacement surgery. The goal is to see if this way of giving antibiotics works well to prevent infection.
Houston, TexasAges 18 years+ - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT07058623Recruiting
Nurse-led telehealth vs in-person follow-up after knee replacement
This trial compares follow-up care with a nurse via video calls or phone versus in-person visits after your first total knee replacement. It aims to see if telehealth is as good as in-person for your recovery.
Hong KongAges 18 years+ - NCT07053943Enrolling by invitation
Comparing single vs. multiple antibiotic doses for hip and knee replacement
This study compares two ways of giving antibiotics before hip or knee replacement surgery to see which one leads to fewer infections needing another surgery. It may help doctors choose the best antibiotic approach for patients having their first joint replacement.
Amsterdam, North HollandAges Any age - NCT07021287Recruiting
Cold therapy after knee replacement surgery
This study compares different cold therapy programs to see which works best for pain and swelling after total knee replacement. Everyone in the study receives cold therapy, and the researchers will track recovery outcomes.
Yiwu, ZhejiangAges 18 years+ - NCT07017400Recruiting
Nerve block for knee replacement pain relief
This trial tests a nerve block called the sacral erector spinae plane block to see if it improves pain control after total knee replacement surgery. If you're having a knee replacement and staying in the hospital overnight, you may be able to join.
CrotoneAges 18 years+ - NCT07020312RecruitingPhase 2
Brain training to improve muscle recovery after joint surgery
This trial tests whether brain-computer interface training can help you regain muscle control more effectively after knee or hip surgery. It focuses on four common procedures and uses neurofeedback to optimize muscle activation during recovery.
Chicago, IllinoisAges 18 years+ - NCT07006545Enrolling by invitation
Getting back to activity after knee replacement
This study looks at how well people can return to daily activities and exercise after total knee replacement surgery. It may help find better ways to guide recovery.
Munich, BavariaAges 18 years+ - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT06991231Recruiting
Cryoablation benefits in knee replacement surgery
This trial tests if a special cold treatment (cryoablation) can help reduce pain or improve recovery for people getting knee replacement surgery for arthritis. It might offer an extra option to feel better after the procedure.
New York, New YorkAges 18 years+ - NCT06968143Recruiting
Patient Satisfaction With Smart Knee Implants Trial
This trial looks at how satisfied patients are with a new 'smart' knee implant that tracks motion and function. If you are getting a total knee replacement, you might be able to join and help compare the smart implant with standard implants.
Chicago, IllinoisAges 18 years+ - NCT06971757Recruiting
Is yearly check-up after hip or knee replacement needed?
This study looks at whether routine check-ups one year after hip or knee replacement are helpful or unnecessary. If you've had or are scheduled for a first hip or knee replacement for arthritis, you may be able to join.
AmsterdamAges 50 years+ - NCT06955481Recruiting
Navigated knee replacement study for better outcomes
This study tests a computer-guided system for total knee replacement. It aims to see if using the OrthoPilot® navigation system helps improve surgical precision and long-term results.
ŠumperkAges 18–80 - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT06946368Recruiting
Exparel for pain after knee replacement
This study tests if a long-lasting numbing medicine called Exparel, given by the surgeon during knee replacement, helps control pain after surgery. It is for people having their first total knee replacement on one knee due to arthritis.
Cleveland, OhioAges Any age - NCT06951477Recruiting
Gut health and knee replacement revision study
This study looks at how the bacteria in your gut might affect recovery after a second knee replacement surgery. Researchers want to learn more about the connection between gut health and surgical outcomes.
London, OntarioAges Any age - NCT06925880Recruiting
Can creatine help seniors recover strength after knee replacement?
This trial tests if taking creatine supplements can help people aged 65+ rebuild muscle mass and strength more quickly after total knee replacement surgery. Participants will take creatine during their standard outpatient rehab program.
Mataró, BarcelonaAges 65 years+ - NCT06929871Recruiting
Cementless vs. cementless knee replacement for osteoarthritis
This trial compares two types of knee replacements: one where the implant is glued in (cemented) and one where it locks into the bone without glue (cementless). It is for people with knee osteoarthritis who need a first-time total knee replacement.
LondonAges 18 years+ - NCT06124482Recruiting
Study of a new knee replacement implant
This trial tests a new knee replacement implant called the FHK®-CK. It is for people who need a new knee due to arthritis or to replace a failed knee implant.
BeaumontAges 18 years+
Hear when a new Total Knee Arthroplasty trial opens
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Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 226 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.