Clinical trials
Total Shoulder Arthroplasty clinical trials
Below are recruiting total shoulder arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03511586Recruiting
Shoulder replacement outcomes registry
This study collects information from people having shoulder replacement surgery with an Arthrex implant. It helps doctors learn how well these implants work over time.
Phoenix, ArizonaAges 18–100 - NCT05487677Recruiting
Add-on repair technique for shoulder replacement
This study looks at an extra repair step (augmentation) done during total shoulder arthroplasty, which is a full shoulder replacement. It may help improve how the repaired shoulder works after surgery.
Redwood City, CaliforniaAges 18 years+ - NCT07604714Recruiting
Shoulder Replacement Surgery: Testing a Bone-Removal Technique
This trial compares two surgical approaches for reverse total shoulder replacement—a procedure that replaces a damaged shoulder joint. Researchers are testing whether removing part of a shoulder bone (the coracoid) helps improve your arm's ability to rotate inward after surgery.
AnnecyAges 18 years+ - NCT03921944Recruiting
CT and nerve tests after shoulder replacement for arthritis
This study checks how well the rotator cuff (the shoulder’s key tendons/muscles) is working after a total shoulder replacement done for arthritis. It uses CT scans and nerve testing to see what affects shoulder structure and function, which may help improve future care.
Hershey, PennsylvaniaAges 45 years+ - NCT05789784Enrolling by invitation
Using a shoulder-mobility app after shoulder replacement
This trial tests whether the Zimmer Biomet mymobility smartphone app improves outcomes after a reverse total shoulder replacement. It may help by supporting follow-up exercises and tracking progress after surgery.
Palm Beach Gardens, FloridaAges 18 years+ - NCT04629391Recruiting
Reverse vs standard shoulder replacement for arthritis
This study compares two types of shoulder replacement surgery for people with arthritis and an intact rotator cuff. The goal is to see which operation works better and is more reliable for your type of shoulder problem.
MeyrinAges 65–85 - NCT04228419Recruiting
Shoulder replacement approach comparison for advanced shoulder arthritis
This trial compares two ways of doing shoulder arthroplasty (shoulder replacement) for people with advanced shoulder arthritis who have not improved with non-surgical treatments. It may help determine which approach works better for pain and function.
Edmonton, AlbertaAges 65 years+ - NCT03804853Recruiting
Rehab program after reverse shoulder replacement surgery
This trial studies a rehabilitation plan after reverse total shoulder arthroplasty (reverse shoulder replacement) to see if it improves recovery. If you are eligible, you may be guided through specific therapy and follow-up visits as part of the study.
Bloomington, MinnesotaAges 55 years+ - NCT05487274Recruiting
Shoulder arthritis surgery plan for specific shoulder bone alignment
This study compares two types of surgery for advanced shoulder osteoarthritis when the shoulder socket is turned backward more than 15 degrees. It aims to see which surgical approach works best for pain and function when the bone alignment issue can be corrected.
Ottawa, OntarioAges 65 years+ - NCT04507412RecruitingPhase 4
IV steroid before shoulder surgery to reduce inflammation
This trial studies whether giving dexamethasone through a vein (an anti-inflammatory steroid) around the time of total shoulder replacement surgery improves outcomes. It may help lower inflammation and related discomfort, but you must meet specific health and medication safety criteria to join.
LuganoAges 58–85 - NCT07410650Enrolling by invitation
Shoulder replacement that spares a key muscle
This study is testing a shoulder replacement surgery that avoids cutting a key muscle (the subscapularis). It may help patients recover shoulder function more quickly with less pain.
Salt Lake City, UtahAges 18–90 - NCT07406893Recruiting
Reducing Infection Risk in Shoulder Replacement Surgery
This trial tests whether a special gel (Prontosan) applied during shoulder replacement surgery can reduce the risk of infection. It is for men having their first shoulder replacement.
St Louis, MissouriAges 18 years+ - NCT06902714RecruitingPhase 3
Tranexamic acid for shoulder replacement recovery
This study tests whether taking an oral medicine called tranexamic acid (TXA) before and after shoulder replacement surgery can reduce bleeding and improve recovery. It is for adults scheduled for a total shoulder replacement who are generally healthy.
Birmingham, AlabamaAges 18–79 - NCT06601803Enrolling by invitationPhase 4
Surgical preparation study for first-time shoulder replacement
This trial tests a surgical prep solution called Surgiphor during first-time total shoulder replacement. It aims to help prevent infections.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07226388Enrolling by invitation
Pyrocarbon hemiarthroplasty vs total shoulder replacement for osteoarthritis
This study compares two types of shoulder replacement surgery for people with osteoarthritis: one that replaces only the ball of the joint (hemiarthroplasty with a pyrocarbon ball) and one that replaces both the ball and socket (total shoulder arthroplasty). The goal is to see which option works better for people with this condition.
St Louis, MissouriAges 40–65 - NCT03839758Recruiting
Personalized implant study for shoulder arthritis
This study looks at a personalized implant/instrument setup for people having shoulder replacement due to wear-and-tear arthritis (and bone tissue death). It aims to see whether customizing the surgery approach improves outcomes over time, including up to 2 years.
Montreal, QuebecAges 18–99 - NCT06891378Recruiting
Home rehab app for patients after shoulder replacement surgery
This trial tests a digital rehab program you can do at home after reverse total shoulder replacement. The goal is to see if an app-based exercise plan helps you recover safely and effectively.
Seoul, Irwon-ro 81Ages 50 years+ - NCT06323980Recruiting
Study of a new stemless shoulder replacement
This trial tests a new shoulder replacement system that does not require a stem (a long piece that goes into the arm bone). It is for patients with severe shoulder arthritis or rotator cuff problems. The study will see how well the device works and how it compares to other treatments.
Irvine, CaliforniaAges 22 years+ - NCT07721415Enrolling by invitationPhase 4
Iodine drapes for shoulder replacement surgery
This trial is testing whether using iodine drapes during a first-time shoulder replacement reduces infection risk. It is for men who are planning this surgery.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06143306RecruitingPhase 4
Adding a second numbing shot for shoulder replacement pain
This study tests whether adding an extra numbing shot (pectoserratus block) to the standard shoulder block reduces pain after total shoulder replacement. It may help you recover more comfortably and use fewer pain medicines.
Minneapolis, MinnesotaAges 18–85 - NCT07145957Recruiting
Pre-surgery exercise program for better shoulder rotation after replacement
This study tests if a special exercise program before shoulder replacement surgery improves how well you can rotate your arm inward after the operation. Participants do exercises for 6 weeks before surgery and are followed for 2 years.
Gainesville, FloridaAges 40–80 - NCT06848023Enrolling by invitation
Shoulder replacement vs tendon repair in older adults
This study compares how well two different shoulder surgeries—reverse total shoulder replacement and rotator cuff repair—work for people 60 and older, at least one year after the operation. If you meet the age and surgery requirements, your results could help doctors decide which procedure is better for older adults.
Germantown, TennesseeAges 60–95 - NCT06133920Recruiting
How long to immobilize after shoulder replacement for broken upper arm
This study compares different durations of immobilization (keeping the arm still) after a reverse total shoulder replacement for a broken upper arm. It aims to find the best approach for recovery.
Camden, New JerseyAges 60 years+ - NCT06733480Recruiting
Band Connect for physical therapy after shoulder surgery
This study tests a new physical therapy tool called Band Connect, which may help people follow their rehab exercises better after shoulder surgery. Researchers want to see if it improves satisfaction and recovery outcomes.
Cleveland, OhioAges 18–89
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Common questions
- Are there clinical trials for total shoulder arthroplasty?
- Yes. Clin2 currently lists 44 recruiting total shoulder arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total shoulder arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total shoulder arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.