Clinical trials
Traumatic Brain Injury clinical trials
Below are recruiting traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 363 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04124029Recruiting
Study how mild brain injuries may relate to dementia
This study looks at how past mild traumatic brain injury may contribute to brain changes seen in chronic traumatic encephalopathy (CTE) and Alzheimer’s disease (AD). It may help researchers understand risk and brain markers by comparing people with mild or moderate TBI, people with mild memory problems, and healthy controls.
Boston, MassachusettsAges 30–90 - NCT04331392Recruiting
Online memory training for people with recent brain injury
This trial tests an online memory program for people with a recent traumatic brain injury (TBI) to help with thinking and memory. It may be useful if your injury is recent and you can safely do MRI scanning.
Toronto, OntarioAges 18–55 - NCT04349852Recruiting
Memory and attention training for adults after brain injury
This trial tests a therapy that helps improve verbal working memory and attention in adults who had a traumatic brain injury (TBI). It may help by training thinking skills that are often affected after an injury, but it’s only for people who meet timing and mental health substance-use requirements.
New York, New YorkAges 18 years+ - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT04499755RecruitingPhase 3
Nucleo CMP Forte for moderate to severe brain injury in children
This trial studies whether a supplement called Nucleo CMP Forte can improve outcomes after a moderate or severe traumatic brain injury in children. It may help families see if adding this treatment makes recovery better and safer.
TantaAges Up to 18 years - NCT04521881RecruitingPhase 3
Testing an antifibrinolytic for mild head injury in older adults
This study tests whether an anti-bleeding medicine (given to reduce unwanted clot breakdown) can improve outcomes after a mild head injury in people 50 and older. It is looking for patients who arrive quickly after injury and have certain symptoms like brief loss of consciousness, confusion, or nausea.
London, LondonAges 50 years+ - NCT04524637Recruiting
Testing a clotting test in recent traumatic brain injury
This trial tests whether a special blood clotting test called thromboelastography can help assess clotting problems after a head injury. It may help doctors better understand bleeding risk and related complications early after trauma.
ShanghaiAges 18–80 - NCT04550377RecruitingPhase 2
Cannabidiol for PTSD, including PTSD after mild head injury
This Phase 2 study tests whether cannabidiol (CBD) can reduce PTSD symptoms, including in people who also had a mild traumatic brain injury (TBI). It’s meant to see if CBD is helpful and safe for PTSD symptoms over the study period.
New York, New YorkAges 18–70 - NCT04588311RecruitingPhase 3
Epoetin to improve outcomes in severe trauma ICU patients
This trial tests epoetin alfa (a blood-building medicine) to help reduce death and severe disability in critically ill trauma patients in the ICU. You may be considered if your ICU team expects a longer stay and the timing after injury is early.
Camperdown, New South WalesAges 18–75 - NCT04708613Recruiting
Brain testing study for former football players and controls
This study looks at how the brain and thinking may be affected by playing professional football, using brain scans and thinking tests. It also compares former players with similar men who did not play organized football beyond high school.
Pittsburgh, PennsylvaniaAges 29–59 - NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT04855396Recruiting
Study of blood markers during hyperbaric oxygen brain injury care
This trial looks at blood “biomarkers,” or lab measurements, while people receive hyperbaric oxygen treatment for brain injury as part of the main HOBIT study. It may help researchers understand who benefits and why by improving how treatment responses are tracked.
San Diego, CaliforniaAges 16–65 - NCT04869059Recruiting
tDCS for mild brain injury memory word finding
This trial tests whether a noninvasive brain stimulation treatment (tDCS) can improve word-retrieval problems after a mild or moderate concussion-like brain injury. It may help if testing shows trouble finding the right words when speaking.
Dallas, TexasAges 18–75 - NCT05663034Recruiting
Compare CBT-I vs MBTI for sleep and trauma symptoms after TBI
This study compares two types of talk-based therapy to help veterans with long-lasting insomnia after a traumatic brain injury (TBI), and also looks at related post-trauma stress symptoms. It may help you improve sleep and reduce how much these symptoms affect daily life.
Eglin Air Force Base, FloridaAges 18 years+ - NCT04945213RecruitingPhase 3
Biperiden to prevent seizures after traumatic brain injury
This trial tests whether biperiden can lower the chance of developing epilepsy after an acute traumatic brain injury (with bleeding or bruising seen on CT). If you qualify, you would get the medicine or a placebo soon after the injury, and researchers will compare outcomes.
Fortaleza, CearáAges 18–75 - NCT04995068Recruiting
Predicting Brain Lesion Risk After Mild Head Injury
This trial studies how to predict who may develop small brain injuries seen on CT scans after a mild traumatic brain injury. It may help doctors decide who needs closer monitoring or follow-up imaging.
StockholmAges 15 years+ - NCT05022940Recruiting
Track recovery and participation after adult brain injury rehab
This study follows adults with traumatic brain injury (TBI) during and after rehabilitation, to better understand how recovery and daily participation change over time. It may help improve rehab programs for people like you in the future.
Montreal, QuebecAges 17 years+ - NCT05065450Recruiting
Testing whether brain stimulation improves memory in epilepsy
This trial looks at ways to improve memory by targeting specific deep brain areas in people with epilepsy. You may be eligible if you are already scheduled for long-term video monitoring with implanted depth electrodes in the memory-related regions (amygdala, hippocampus, and nearby areas).
St Louis, MissouriAges 18–75 - NCT05084352Recruiting
Monitoring vital signs to predict recovery after head injury
This study checks vital signs (like heart rate and breathing) in the first hours after a traumatic brain injury to predict whether neurological function may decline. It may help doctors spot patients at higher risk sooner and adjust care earlier.
Baltimore, MarylandAges 18–79 - NCT05095857RecruitingPhase 4
Ketamine to improve care in severe acute brain injury
This Phase 4 trial tests whether giving ketamine during anesthesia is safe and helpful for adults with severe sudden brain injuries after surgery. It may improve how patients are sedated and cared for while they are on a breathing machine.
CopenhagenAges 18 years+ - NCT05097261RecruitingPhase 4
Ketamine for adults with severe brain injury in the ICU
This trial studies whether ketamine can improve outcomes for adults with severe traumatic brain injury when they are in the ICU and need sedation. It focuses on patients who have pressure monitoring inside the brain soon after admission.
BonheidenAges 18 years+ - NCT05205174Recruiting
Check a scalp sensor to detect brain swelling after injury
This study tests whether a sensor on the scalp can detect a wave of abnormal electrical activity in the brain after a traumatic brain injury (TBI). The goal is to help clinicians monitor and possibly treat dangerous pressure build-up in the brain.
Minneapolis, MinnesotaAges Any age - NCT05233475Recruiting
Rehab program after concussion in Danish adults
This trial tests a “get going” rehabilitation program for people who recently had a concussion (mild brain injury) from a head impact. It may help reduce concussion symptoms and improve day-to-day functioning in the months after injury.
Hammel, Deb´nmarkAges 18–60 - NCT05261477Recruiting
Kid Brain Injury Education and Care Navigation Program
This trial tests a family support program that teaches caregivers and helps coordinate outpatient care after a traumatic brain injury. It may help families better understand recovery and connect with rehabilitation services.
Colorado Springs, ColoradoAges 3 years+
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Common questions
- Are there clinical trials for traumatic brain injury?
- Yes. Clin2 currently lists 363 recruiting traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.