Clinical trials
Treatment Resistant Schizophrenia clinical trials
Below are recruiting treatment resistant schizophrenia clinical trials, each written for real people, not researchers. We’re tracking 64 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05074732Recruiting
Study of forensic mental health admissions after a service move
This study looks at all adult admissions to Ireland’s National Forensic Mental Health Service during a specific time window. It may help improve how the new forensic service at Portrane runs in the future.
DublinAges 18 years+ - NCT06505668Recruiting
Comparing two heart rate medicines for clozapine users
This study compares two medications (atenolol and ivabradine) to see which one better controls a fast heart rate (tachycardia) in people with treatment-resistant schizophrenia who are taking clozapine. The goal is to find a safer way to manage this side effect.
Bhubaneswar, OdishaAges 18–60 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT05952674Recruiting
Vagus nerve stimulation for long-term depression symptoms
This trial studies whether a device that stimulates the vagus nerve (VNS) can help people with treatment-resistant depression or related mood disorders that have not improved despite multiple therapies. It may help by targeting mood symptoms when other treatments haven’t worked well.
Angers, FranceAges 18 years+ - NCT07091344Recruiting
VR-based therapy for voice hearing in schizophrenia
This study tests whether a virtual reality therapy that lets you talk to an avatar of the voice you hear can help reduce distress and improve thinking skills. It's for people with schizophrenia who hear voices regularly and are on stable medication.
Barcelona, CataloniaAges 18 years+ - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75 - NCT06511908RecruitingPhase 2
Testing a new ketamine-like drug for hard-to-treat depression
This study tests a new experimental drug (2R,6R)-HNK, a chemical related to ketamine, given by IV infusion to see if it can help people with depression that hasn't improved with other treatments. The goal is to find a new option for people who have not found relief from standard antidepressants.
Bethesda, MarylandAges 18–70 - NCT06480201RecruitingPhase 1
Ketamine for treatment-resistant depression: a brain wave study
This study tests whether a single dose of ketamine can change brain wave patterns (called gamma oscillations) in people with treatment-resistant depression. Researchers want to see if these brain waves can predict who will feel better after treatment.
Houston, TexasAges 21–45 - NCT05377177Recruiting
Brain stimulation type test for suicidal thoughts in depression
This study tests whether stimulating the brain on both sides at once versus one side can reduce suicidal thoughts in people with treatment-resistant depression. It also looks at brain “inhibition” signals to help predict who benefits.
San Diego, CaliforniaAges 18–70 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65 - NCT07521683Enrolling by invitationPhase 2
NS-136 treatment study for schizophrenia relapse
This study tests whether NS-136, a new medication, can help people with schizophrenia who are experiencing a relapse or worsening of symptoms. The study measures how well the medication works and what side effects it causes.
ShanghaiAges 18–65 - NCT04917302RecruitingPhase 2
NMDA and anti-inflammatory add-on for treatment-resistant schizophrenia
This trial tests whether combining an NMDA “signal-supporting” treatment with an anti-inflammatory medicine can reduce symptoms in people with schizophrenia who don’t respond well to usual antipsychotic drugs. If you’ve tried at least two antipsychotics and you’re still symptomatic, this study may be worth screening for.
TaichungAges 18–65 - NCT06574360RecruitingPhase 2
Study of a dual-target drug for hard-to-treat schizophrenia
This trial tests an experimental combination treatment that targets two different brain receptors (sigma-1 and NMDA) to see if it can improve symptoms in people with schizophrenia that hasn't responded well to standard antipsychotics.
TaichungAges 18–65 - NCT04956016Recruiting
Compare two rTMS treatments for moderate to severe depression
This study tests whether a classic type of brain stimulation (rTMS) works better or the same as a deeper version for depression that keeps coming back or is ongoing. You may be offered one of the two stimulation options to see which helps reduce depressive symptoms.
PoitiersAges 18 years+ - NCT05019885RecruitingPhase 2
IV ketamine for hard-to-treat epilepsy in adults
This Phase 2 study tests whether a low dose of IV ketamine can reduce seizures in adults with drug-resistant epilepsy. It may help people whose seizures continue despite trying at least two appropriate seizure medicines.
New York, New YorkAges 18 years+ - NCT06218030RecruitingPhase 4
L-methylfolate for treatment-resistant anxiety
This study tests whether adding L-methylfolate (a form of vitamin B9) to your current antidepressant can help with generalized anxiety disorder that has not responded to other treatments. It is for adults who are already on a stable dose of an SSRI or SNRI medication.
Kingston, OntarioAges 18–65 - NCT06599372Recruiting
TMS for resistant voices in schizophrenia
This trial tests if a non-invasive brain stimulation method called transcranial magnetic stimulation (TMS) can reduce stubborn auditory hallucinations (hearing voices) in people with schizophrenia who haven't improved enough with medication.
Neuilly-sur-MarneAges 18 years+ - NCT06518720RecruitingPhase 2
Psilocybin for Chronic Nerve Pain and Depression
This trial tests whether psilocybin (a psychedelic medication) can help people who have both chronic nerve pain and depression that hasn't responded to standard treatments. The goal is to see if it can reduce pain and improve mood.
Toronto, OntarioAges 18–65 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Birmingham, AlabamaAges 18–65 - NCT06902298RecruitingPhase 1/Phase 2
Ultrasound brain stimulation for depression
This trial tests a new, non-invasive ultrasound treatment for people with depression who haven't gotten enough relief from at least two prior treatments. It uses sound waves to gently stimulate areas of the brain linked to mood.
Salt Lake City, UtahAges 18–65 - NCT05393622Recruiting
Brain stimulation trial for severe, treatment-resistant depression
This study tests an implanted form of brain stimulation for people with severe depression that has not improved with multiple medication trials. If you qualify, you would have brain scans and surgery planning, then follow a treatment-and-safety plan for several months.
Boston, MassachusettsAges 21–80 - NCT07748091Recruiting
Brain wave and inflammation markers in shock therapy for depression
This study looks at brain wave patterns and markers of inflammation in people with depression that hasn't improved with other treatments and who are receiving electroconvulsive therapy (ECT, also known as shock therapy). The goal is to understand how these markers might relate to how well ECT works.
Istanbul, BakırköyAges 18–60
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Common questions
- Are there clinical trials for treatment resistant schizophrenia?
- Yes. Clin2 currently lists 64 recruiting treatment resistant schizophrenia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a treatment resistant schizophrenia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a treatment resistant schizophrenia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.