Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06925204Recruiting
Study on chronic pancreatitis and its treatments
This study looks at how chronic pancreatitis changes over time and how treatments work. It may help doctors find better ways to manage the condition.
Shanghai, Shanghai MunicipalityAges Any age - NCT06925243RecruitingPhase 3
Apatinib, Sintilimab, and Chemo for Intestinal Gastric Cancer
This phase 3 trial tests adding the targeted drug apatinib to a standard combination of sintilimab (immunotherapy) and chemotherapy (SOX regimen) given before surgery for a specific type of stomach or gastroesophageal junction cancer (intestinal type, HER2-negative). The goal is to see if the three-drug combination works better than the two-drug combination in shrinking the tumor and improving outcomes before surgery.
Lanzhou, GansuAges 18–75 - NCT06925594RecruitingPhase 3
Cell injection for Crohn's-related anal fistulas
This trial tests a new cell injection (TH-SC01) to treat anal fistulas caused by Crohn's disease. It aims to see if the injection can heal fistulas and lower infection risk.
Nanjing, JiangsuAges 18–70 - NCT06926075RecruitingPhase 1/Phase 2
Early trial of KESONOTIDE™ for solid tumors
This trial tests a new tablet called KESONOTIDE™ for people with solid tumors that have spread. The goal is to see if it can help when other treatments have stopped working or are not an option.
Kogarah, New South WalesAges 18 years+ - NCT06926374Recruiting
Robotic surgery for gastrointestinal and urologic conditions
This trial tests a new robotic surgery system for common operations on the colon, rectum, prostate, kidney, bladder, stomach, esophagus, gallbladder, and hiatal hernia. It may offer a less invasive option for patients who need surgery for these conditions.
Hong KongAges 18–80 - NCT06928259Recruiting
A study of hepatitis C treatments and other medications
This trial looks at how two hepatitis C treatments (GLE/PIB or SOF/VEL) interact with other drugs or recreational substances. It may help doctors understand how to better manage treatment for people taking multiple medications.
CadizAges Any age - NCT06928350Recruiting
Normal esophagus readings in healthy Indian adults
This trial is studying normal acid and fluid movement in the esophagus of healthy people in India. It will help doctors better understand what is typical, which may improve care for people with acid reflux or other swallowing issues.
Hyderabad, TelanganaAges 18–50 - NCT06928545Recruiting
MagDI procedure registry for weight loss
This registry tracks people who have a MagDI procedure, a type of weight-loss surgery that connects parts of the intestine. It helps doctors learn how well the procedure works over time.
Ventura, CaliforniaAges 22 years+ - NCT06928714Recruiting
Feeding problems in children at Amiens Hospital
This study is for children with long-term feeding difficulties that involve medical, nutritional, emotional, or skill-related problems. It aims to understand these challenges better and improve care.
AmiensAges Up to 18 years - NCT06929013Recruiting
Blood marker study for colorectal cancer spread to belly
This study looks at how certain blood markers (nucleosome and CTCF) clear from the body in people with colorectal cancer that has spread to the lining of the belly. It also includes people with other conditions to compare. The goal is to learn more about these markers to help guide treatment.
Pierre-BéniteAges 18 years+ - NCT06929845Recruiting
Organoid models for liver cancer study
This study uses tumor samples to create lab-grown mini-livers (organoids) to better understand liver cancer. It may help researchers learn more about the disease and develop new treatments.
RomaAges 18 years+ - NCT06929949Recruiting
Best Reconnection Method After Upper Stomach Surgery
This study compares different ways of reconnecting the digestive tract after surgery to remove the upper part of the stomach. It aims to see which method leads to a better quality of life for people with early-stage stomach or esophageal junction cancer.
Changchun, JilinAges 18–75 - NCT06935708RecruitingPhase 4
Comparing morphine to epidural pain relief for colon surgery
This study compares two pain relief methods—morphine given through a spinal needle versus pain medicine delivered through a tiny tube in the back—after colorectal cancer surgery. It aims to see which approach works better for controlling pain.
SplitAges 18–80 - NCT06936501Recruiting
Cooling sensation drink test for safe swallowing after stroke
This trial tests a cooling sensation drink to help stroke patients with swallowing problems safely take a high-calorie, high-protein supplement. It looks at whether the cooling sensation makes swallowing easier and safer.
Málaga, MálagaAges 18–99 - NCT06936774RecruitingPhase 3
Intensive follow-up after rectal cancer surgery to improve recovery
This study tests whether a more intensive follow-up program after rectal cancer surgery can improve your recovery, daily function, and overall quality of life. If you've had a temporary ileostomy and are waiting for reversal, this extra support may help you feel better faster.
BaselAges 18 years+ - NCT06936878Recruiting
BOLSTER: Learning skills to thrive with advanced cancer
This study tests a program called BOLSTER to help you learn new skills to thrive while managing advanced cancer and a complex care need. You and a family caregiver will participate together.
Boston, MassachusettsAges 18 years+ - NCT06937112Recruiting
A new scan for early detection of certain cancers
This trial tests a new imaging agent (18F-FAPI) to see if it can help find tumors early in people with lung, thyroid, pancreatic, melanoma, or neuroendocrine cancers.
Nanjing, JiangsuAges 18–75 - NCT06937294RecruitingPhase 4
Metformin for diabetes from chronic pancreatitis
This trial tests if metformin is safe and effective for people who developed diabetes after being diagnosed with chronic pancreatitis. You must not have taken any diabetes medication before.
Shanghai, Shanghai MunicipalityAges 18–65 - NCT06937567RecruitingEarly Phase 1
CDH17 car-t therapy for advanced solid tumors
This trial tests a new treatment called CDH17 CAR-T for people with advanced solid tumors like colorectal, stomach, pancreatic, or bile duct cancer. It is for patients who have tried other treatments without success. The therapy uses your own immune cells, modified to target a protein called CDH17 found on some cancer cells.
Hangzhou, ZhejiangAges 18–70 - NCT06938295Recruiting
Comparing two types of ultrasound for inflammatory bowel disease
This study tests if a standard ultrasound is as good as a high-end one at seeing inflammation in the gut. It could help people with IBD avoid more invasive procedures.
Hyderabad, TelanganaAges 18–75 - NCT06938321RecruitingPhase 1/Phase 2
New drug combo for advanced bile duct and gallbladder cancer
This trial tests two new drugs, AK130 and AK112, for people with advanced bile duct or gallbladder cancer that has stopped responding to standard chemotherapy. The goal is to see if this combination can help shrink tumors or slow the cancer's growth.
Beijing, Beijing MunicipalityAges 18–75 - NCT06938971Recruiting
Exercise for quality of life in metastatic colorectal cancer
This trial tests whether a combination of resistance and aerobic exercise can improve quality of life for people starting their first round of chemotherapy for metastatic colorectal cancer. If you are newly diagnosed and not already exercising regularly, this study may help you feel better during treatment.
CopenhagenAges 18 years+ - NCT06938945Recruiting
Symptom Tracking App for Liver Cancer Immunotherapy
This trial tests whether using a smartphone app to regularly report your symptoms can help you and your doctor manage side effects better during immunotherapy treatment for liver cancer. It is a study where you would be randomly assigned to either use the app or receive usual care.
Haidian, Beijing MunicipalityAges 18–75 - NCT06939023Recruiting
Robot vs. keyhole surgery for left-side pancreas growths
This trial compares robot-assisted surgery with standard keyhole surgery to remove growths on the left side of the pancreas. It may help doctors determine which method is safer and more effective for non-cancerous or pre-cancerous conditions.
AmsterdamAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.