Gastroenterology
Digestive system clinical trials
Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We’re tracking 7,896 recruiting studies in this area right now.
By phase
- Not applicable4,922
- Phase 21,186
- Phase 1581
- Phase 3466
- Phase 1/Phase 2394
- Phase 4236
- Phase 2/Phase 3111
Top conditions
- Colorectal Cancer492
- Gastric Cancer297
- Pancreatic Cancer292
- Hepatocellular Carcinoma283
- Esophageal Cancer191
- Rectal Cancer176
- Breast Cancer147
- Crohn Disease144
- Ulcerative Colitis141
- Colon Cancer115
- Inflammatory Bowel Diseases108
- Hepatocellular Carcinoma (HCC)106
- Liver Cancer100
- Lung Cancer98
- Pancreas Cancer94
- Esophageal Squamous Cell Carcinoma88
- Ovarian Cancer88
- Cystic Fibrosis78
Leading sponsors
- Fudan University104
- Sun Yat-sen University90
- Mayo Clinic74
- Chinese University of Hong Kong60
- M.D. Anderson Cancer Center58
- Second Affiliated Hospital, School of Medicine, Zhejiang University57
- Assistance Publique - Hôpitaux de Paris55
- Sixth Affiliated Hospital, Sun Yat-sen University50
- National Taiwan University Hospital49
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences48
Where studies are running
- California462
- Arizona177
- Texas149
- Florida134
- Massachusetts128
- New York123
- Alabama122
- Maryland86
- Ohio80
- Pennsylvania72
Recruiting studies7,896 total
- NCT06914349Recruiting
Comparing two ways to reconnect the stomach after Whipple surgery
This trial compares two common surgical techniques for reconnecting the stomach and small intestine during a Whipple procedure (pancreaticoduodenectomy) to see if one leads to fewer complications. It may help surgeons choose the best approach for you.
LarissaAges 18–80 - NCT06914635Recruiting
Immunotherapy hub study for liver tumor patients
This trial is checking how the immune system works in people with primary liver cancer, looking at ways to prevent infections and manage the tumor. It is an observational study—meaning no new treatments are given—so it helps doctors learn more without adding extra medications.
Pavia, PaviaAges 18–90 - NCT06914648Recruiting
Liver preparation before surgery study for certain liver cancers
This study tests a procedure called portal vein embolization (PVE) to help grow the healthy part of the liver before surgery. It may be an option for people with certain liver cancers who need more healthy liver tissue before their operation.
New Haven, ConnecticutAges 18 years+ - NCT06914674RecruitingPhase 2
Tamoxifen for advanced pancreatic SPTP
This trial tests whether tamoxifen, a hormone therapy drug, can shrink or slow down advanced solid pseudopapillary tumors of the pancreas (SPTP) that have estrogen and progesterone receptors. It may be an option for people whose tumors cannot be removed by surgery or have come back after other treatments.
ShanghaiAges 14–80 - NCT06915389Recruiting
Gastric cancer: predicting immune therapy side effects
This trial studies whether blood tests before treatment can predict side effects from immunotherapy (PD-1/PD-L1 inhibitors) in people with gastric cancer. If you are about to start this type of treatment, your participation could help doctors manage side effects better.
Xining, QinghaiAges 18–80 - NCT06915753RecruitingPhase 1
TYRA-430 for advanced liver cancer and other solid tumors
This trial tests an oral drug called TYRA-430 for people with advanced liver cancer (HCC) or other solid tumors that have changes in the FGF/FGFR pathway. It aims to see how safe the drug is and whether it can shrink tumors or slow cancer growth.
Los Angeles, CaliforniaAges 18 years+ - NCT06915961Recruiting
HE4 Protein and Lung Function in Cystic Fibrosis
This study looks at a protein in the blood (HE4) and how it relates to lung function in children with cystic fibrosis. It also tests a quality improvement plan to help manage CF. The goal is to find better ways to track and treat the disease.
Cairo, AbbasiaAges 6 years+ - NCT06916390RecruitingPhase 4
Testing guselkumab with antibiotics for chronic pouchitis
This study tests whether adding a medication called guselkumab to antibiotics can help people with chronic or recurring pouchitis, a condition that causes inflammation in the J-pouch after ulcerative colitis surgery. Participants will take antibiotics for the first 4 weeks and guselkumab as an injection over the course of the trial.
Leuven, Vlaams-BrabantAges 18 years+ - NCT06917079RecruitingPhase 1
BBO-11818 for KRAS-mutated cancers
This trial tests a new oral drug (BBO-11818) for people with solid tumors that have a specific KRAS mutation. It's for those whose cancer has spread or cannot be removed by surgery and who have not had other cancers recently.
Los Angeles, CaliforniaAges 18 years+ - NCT06917716Recruiting
Chinese pain survey for chronic pancreatitis patients
This study is testing a new questionnaire to better measure pain in people with chronic pancreatitis. It aims to help doctors understand and treat your pain more effectively.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT06917963Recruiting
Preventing high stoma output with omeprazole
This trial tests if a stronger dose of omeprazole can help prevent high fluid output from a new ileostomy (a surgically created opening in the belly that passes waste). If you are scheduled for surgery to create an ileostomy, you may be able to join.
Gdansk, Pomeranian VoivodeshipAges 18 years+ - NCT06919068Recruiting
Colon camera capsule for gut bacteria in the blood
This trial tests whether a camera capsule can detect problems in the large intestine when certain gut bacteria are found in the blood. If you have one of these bacteria and are stable enough for the exam, it might help identify the source of the infection.
OdenseAges 18 years+ - NCT06920680Recruiting
A registry for colonoscopy reports and videos
This study is a registry that collects information and videos from colonoscopy procedures. It helps doctors learn more about these tests and improve care for patients like you.
Stuttgart, Baden-WurttembergAges 18 years+ - NCT06921161Recruiting
TongueFit therapy for swallowing problems in children
This study tests a new device called TongueFit that helps children strengthen their tongue muscles to improve swallowing. If your child has trouble swallowing due to weak tongue muscles, this therapy may help.
Jakarta, Jakarta Special Capital RegionAges 3–16 - NCT06921837RecruitingPhase 1/Phase 2
BDC-4182 for advanced gastric or gastroesophageal cancer
This trial tests a new drug called BDC-4182 for advanced gastric or gastroesophageal cancer. It is for people who have already tried standard treatments and may target a protein called Claudin 18 on some cancer cells.
Darlinghurst, New South WalesAges 18 years+ - NCT06922383RecruitingPhase 1/Phase 2
Study of arfolitixorin in advanced colorectal cancer
This study tests a new drug called arfolitixorin given with standard chemotherapy (FOLFOX or FOLFIRI) plus a targeted therapy for people with advanced colorectal cancer that has spread. It may help the chemotherapy work better.
BerlinAges 18 years+ - NCT06922669Recruiting
Steroids for drug-induced liver injury with high bilirubin
This trial tests whether steroids (glucocorticoids) can help people with acute liver injury caused by a drug, especially when bilirubin levels are high. It aims to see if steroids can reduce liver damage and improve recovery.
Shenyang, LiaoningAges 18–80 - NCT06923150Recruiting
MiniGo vs. standard care for bowel symptoms after rectal cancer surgery
This trial tests a small, portable device called MiniGo that uses a gentle water rinse to help control bowel symptoms after rectal cancer surgery. It may be an option for people who still have bothersome bowel problems despite trying other treatments.
AmiensAges 18 years+ - NCT06923345RecruitingPhase 2
Modified long-course radiation and chemo with immunotherapy for rectal cancer
This trial tests a treatment plan involving radiation, chemotherapy, and an immunotherapy drug (a PD-1 inhibitor) for people with a specific type of high-risk rectal cancer. The goal is to see if this combination helps shrink the tumor before surgery.
Guangzhou, GuangdongAges 18–75 - NCT06923449Recruiting
Gastric cancer surgery and tumor board performance study
This study looks at how tumor board discussions affect outcomes for people having surgery to cure gastric cancer. If you have gastric adenocarcinoma and are scheduled for curative surgery, you may be able to join.
Rome, ITAges 18 years+ - NCT06923761RecruitingPhase 1/Phase 2
Trial of a new drug for advanced solid tumors
This trial tests a new drug (GRWD5769) that may help your immune system fight cancer. It is for people with advanced solid tumors that have stopped responding to standard treatments, including certain types of cervical, liver, and other cancers.
AdelaideAges 18 years+ - NCT06923787RecruitingPhase 2
Lidocaine for colon cancer surgery recovery
This trial tests whether giving lidocaine through an IV during and after colon cancer surgery can help with recovery and boost your immune system. It's for people having laparoscopic colon surgery who haven't had chemotherapy before.
LjubljanaAges 18–80 - NCT06923800Recruiting
Exercise and Diet Advice for Fibromyalgia and IBS
This study tests whether combining exercise with dietary advice can help people who have both fibromyalgia and irritable bowel syndrome (IBS). It aims to see if this approach improves symptoms and quality of life.
Castellana Grotte, BariAges 30–65 - NCT06925061RecruitingPhase 2
Testing EXL01 to prevent Crohn's disease return after surgery
This study tests a new oral treatment called EXL01 to see if it can prevent Crohn's disease from coming back after surgery to remove part of the small and large intestine. It may be an option if you are not planning to use strong immune-suppressing drugs (except anti-TNF) in the next 6 months.
Clermont-FerrandAges 18 years+
Common questions
- How many digestive system clinical trials are recruiting?
- Clin2 is tracking 7,896 recruiting gastroenterology studies from the U.S. registry right now, out of 12,425 we cover in this area in total.
- What does “Digestive system” cover here?
- Conditions of the stomach, intestines, liver, and the rest of the digestive tract. We group each study into digestive system based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a digestive system trial near me?
- Use the search to filter digestive system studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
- Cancer
- Brain & nervous system
- Heart & circulation
- Hormones & metabolism
- Mental health
- Lungs & breathing
- Immune system & allergy
- Women’s health & pregnancy
- Skin
- Blood & lymphatic
- Kidney & urinary
- Infections
- Genetic & congenital
- Bones, joints & muscles
- Pain
- Injuries & trauma
- Mouth & dental
- Eyes & vision
- Ear, nose & throat
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.