Immunology & allergy
Immune system & allergy clinical trials
Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We’re tracking 6,236 recruiting studies in this area right now.
By phase
- Not applicable3,144
- Phase 21,066
- Phase 1823
- Phase 1/Phase 2446
- Phase 3426
- Phase 4238
- Phase 2/Phase 393
Top conditions
- Multiple Sclerosis345
- Multiple Myeloma334
- Asthma194
- Lymphoma183
- Rheumatoid Arthritis141
- Type 1 Diabetes131
- Atopic Dermatitis129
- Systemic Lupus Erythematosus126
- Acute Lymphoblastic Leukemia123
- HIV Infections117
- Chronic Lymphocytic Leukemia100
- Autoimmune Diseases81
- Follicular Lymphoma74
- Diabetes Mellitus, Type 170
- Hodgkin Lymphoma67
- Leukemia64
- Rheumatoid Arthritis (RA)64
- Mantle Cell Lymphoma62
Leading sponsors
- Institute of Hematology & Blood Diseases Hospital, China91
- National Institute of Allergy and Infectious Diseases (NIAID)91
- National Cancer Institute (NCI)74
- Assistance Publique - Hôpitaux de Paris70
- Novartis Pharmaceuticals65
- M.D. Anderson Cancer Center63
- AstraZeneca57
- City of Hope Medical Center46
- Mayo Clinic46
- Memorial Sloan Kettering Cancer Center45
Where studies are running
- California492
- Maryland196
- Alabama179
- Arizona141
- Florida141
- New York122
- Massachusetts120
- Texas119
- Illinois82
- Colorado77
Recruiting studies6,236 total
- NCT06343792RecruitingPhase 2
Testing RLS-0071 for steroid-resistant acute graft-versus-host disease
This trial tests a new drug, RLS-0071, for people who are hospitalized with acute graft-versus-host disease that hasn't improved with steroids. It aims to see if the drug is safe and can help control the condition.
Duarte, CaliforniaAges 12 years+ - NCT06470971RecruitingPhase 2
Siltuximab to prevent severe side effects during immunotherapy rechallenge
This trial tests if siltuximab can prevent severe immune-related side effects when patients restart immunotherapy (anti-PD-1/PD-L1) after previous severe side effects. It aims to make rechallenge safer for people with advanced cancer.
Columbus, OhioAges 18 years+ - NCT06463119Recruiting
Vaccine response registry for immune-weakened patients
This study creates a registry to track how people with weakened immune systems respond to vaccines. It helps doctors better understand which vaccines work best for patients like you.
GenevaAges Any age - NCT06286644Recruiting
Hops compounds and your immune system
This study looks at how compounds found in hops (used in beer) affect your immune system. If you are a healthy adult, you may join and help researchers learn more about how these natural substances work.
ViennaAges 18–70 - NCT06235892RecruitingPhase 3
Lowering Tacrolimus for Low-Risk Kidney Transplant Patients
This trial tests whether safely lowering the dose of tacrolimus—an anti-rejection drug—can still protect a kidney transplant one year after surgery. It's for first-time transplant recipients with low immune risk.
NantesAges 18 years+ - NCT06208137Recruiting
Using immune risk score to guide recovery after stem cell transplant
This study uses a special score (immune risk score) to check how well your immune system rebuilds after a half-matched stem cell transplant. The goal is to find patients who might need extra help with immune recovery.
Tianjin, Tianjin MunicipalityAges 16 years+ - NCT06264817Recruiting
Adjustable sleeve for arm swelling after breast cancer
This trial tests a new adjustable compression sleeve for arm swelling (lymphedema) after breast cancer. It aims to see if the sleeve is comfortable and effective at reducing swelling.
AnkaraAges 18 years+ - NCT06263361Recruiting
Making brain biopsies safer for lymphoma patients
This trial tests a new method to improve the safety and accuracy of brain biopsies in people with a type of lymphoma that starts in the brain or spinal cord. It may help reduce complications and get more reliable results.
Milan, MilanAges 18 years+ - NCT06268769RecruitingPhase 4
Comparing two tacrolimus drugs in kidney transplant patients
This study compares two long-acting forms of tacrolimus (Envarsus and Advagraf) to see how the body processes them after a kidney transplant. It aims to find the best way to use these medications to prevent organ rejection.
AachenAges 18 years+ - NCT06312748RecruitingPhase 1
Improving blood vessels in veterans with heart failure
This test is looking at whether certain medications (like statins) can help improve blood vessel health in veterans who have heart failure with preserved pumping function. It may help reduce symptoms and keep you out of the hospital.
Salt Lake City, UtahAges 18 years+ - NCT06262776Recruiting
Shingles vaccine safety study for transplant recipients
This trial tests whether the shingles vaccine (RZV) is safe and works well for organ transplant recipients and their household members. It also includes people on dialysis or certain immunosuppressants.
Adelaide, South AustraliaAges 18 years+ - NCT07199764RecruitingPhase 2
Maintenance therapy using combination immunotherapy for pancreatic cancer
This trial tests a combination of immunotherapy drugs (targeting CD40 and other immune cells) as a maintenance treatment for people with advanced pancreatic cancer that has not grown or has shrunk after initial chemotherapy. The goal is to see if this approach can keep the cancer from progressing longer.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06317558Recruiting
Real-world study of immunotherapy before surgery for lung cancer
This study looks at how well immunotherapy given before surgery works for non-small cell lung cancer. It aims to help doctors understand real-world outcomes for patients who receive this treatment.
Beijing, Beijing MunicipalityAges 18–85 - NCT06272500Recruiting
Betaine for high gastrin in autoimmune gastritis
This trial tests if betaine hydrochloride can lower high gastrin levels caused by autoimmune gastritis. It may help people with this condition by reducing stomach-related symptoms.
Zhengzhou, HenanAges Any age - NCT05937295RecruitingPhase 1
Peptide vaccine plus immunotherapy for a specific cancer gene fusion
This Phase 1 study tests a custom vaccine made to match a specific cancer genetic change (DNAJB1-PRKACA fusion). It’s combined with an approved immunotherapy (immune checkpoint inhibitor) to help your immune system recognize and fight the cancer. You may be considered if your cancer is advanced or has spread and you meet several blood/organ and health requirements.
Tübingen, Baden-WürtembergAges 18 years+ - NCT06015256Recruiting
Natural killer cells in severe asthma patients
This study looks at immune cells called natural killer cells in people with severe asthma. Researchers want to see how these cells are different in people whose asthma is well-controlled, not well-controlled, or flaring up, compared to healthy volunteers without asthma.
MarseilleAges 18 years+ - NCT05921305RecruitingPhase 3
Low-dose methotrexate plus steroid for early acute GVHD
This Phase 3 trial tests whether a specific low-dose medication (methotrexate) together with standard steroid treatment can improve early outcomes in patients with acute graft-versus-host disease after a stem cell transplant. It may help control the immune reaction that attacks the body after transplant.
Beijing, Beijing MunicipalityAges 15–65 - NCT06025240Recruiting
Better antibody monitoring after kidney transplant
This study tests a new way to monitor harmful antibodies after a kidney transplant. It may help prevent transplant rejection over time.
Liverpool, MerseysideAges 18 years+ - NCT05950724Enrolling by invitationEarly Phase 1
TNF blocker to protect lungs after transplant
This early-stage trial tests whether blocking a specific inflammation signal (TNF-alpha) can help prevent or improve kidney problems and early graft (new lung) dysfunction after a lung transplant at Northwestern. You might be eligible if you’re scheduled for that transplant and are willing to go through study consent and follow-up.
Chicago, IllinoisAges 18 years+ - NCT05902741Recruiting
Race-based stress program for Black women
This trial studies whether a specific stress-reduction program tailored to race can improve stress and health for Black women after menopause. It may help you learn coping skills that could benefit blood pressure, cholesterol, or diabetes-related outcomes.
Maywood, IllinoisAges 50–75 - NCT05820802Recruiting
Studying immune cells in children during surgery
This study looks closely at immune cells in children while they are having surgery under general anesthesia using a specific muscle-relaxing medicine (rocuronium). It may help researchers understand how immune systems respond around the time of surgery and anesthesia.
SeoulAges 2–18 - NCT05664035Recruiting
Measuring infection patterns in adults with frequent respiratory infections
This study looks at how often “SPAD” happens in adults who get repeated bacterial infections in the chest or sinuses. It aims to better understand your infection frequency and related immune test results, which may help guide future care.
LilleAges 18–65 - NCT05858632RecruitingPhase 4
Study immune patterns during guselkumab skin response in psoriasis
This trial studies how the immune system changes in the skin after guselkumab treatment for psoriasis, including the scalp. You may be asked to meet certain scalp severity and medication safety rules.
San Francisco, CaliforniaAges 18 years+ - NCT05775718RecruitingPhase 2
Shingrix shot after bone marrow transplant to prevent shingles
This Phase 2 study tests whether an additional Shingrix (RZV) vaccine dose helps prevent shingles in people who previously had an allogeneic bone marrow or stem cell transplant. It focuses on people who are at least a year out from their first two Shingrix doses.
Aurora, ColoradoAges 18–79
Common questions
- How many immune system & allergy clinical trials are recruiting?
- Clin2 is tracking 6,236 recruiting immunology & allergy studies from the U.S. registry right now, out of 9,675 we cover in this area in total.
- What does “Immune system & allergy” cover here?
- Autoimmune conditions, allergies, and disorders of the body’s immune defenses. We group each study into immune system & allergy based on the conditions it studies, so you can scan the whole therapeutic area at once and drill into a specific condition.
- How do I find a immune system & allergy trial near me?
- Use the search to filter immune system & allergy studies by location and eligibility. Every Clin2 trial page explains the criteria in plain English and offers a short, optional pre-screen for a fit read — the study team makes the final decision.
Other specialties
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov; specialty groupings are derived from each study’s conditions. Talk with your doctor about whether a specific trial is right for you.