Treatment
Esketamine clinical trials
We’re tracking 57 recruiting studies that include Esketamine, each written for real people, not researchers, below.
Recruiting studies
- NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT04303325RecruitingPhase 4
Esketamine after breast surgery for depression and gut changes
This trial studies whether esketamine given around the time of breast cancer surgery can improve depression and change gut bacteria. It also monitors your sleep/deep anesthesia level (with a simple monitoring number).
Shenyang, LiaoningAges 18–65 - NCT05450432RecruitingPhase 4
Ketamine maintenance to help prevent suicidal thoughts
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
Boston, MassachusettsAges 18–70 - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05973851RecruitingPhase 3
Six-week medicine boost for depression after first treatment failure
This study tests a more intensive antidepressant medicine approach for people whose first tried treatment didn’t work well enough. It compares the intensified treatment with usual care, aiming to improve depression symptoms and daily functioning.
InnsbruckAges 18–65 - NCT06161805RecruitingPhase 3
Esketamine for chronic pain from endometriosis
This trial tests if esketamine, a nasal spray, can reduce chronic pelvic pain in women with endometriosis that hasn't improved with standard painkillers. You may qualify if you have severe pain and are scheduled for endometriosis surgery.
DelftAges 18–50 - NCT06430645Recruiting
Esketamine and recovery after propofol anesthesia
This trial tests whether adding esketamine to propofol anesthesia helps women wake up faster after a short gynecologic procedure called operative hysteroscopy. It may offer quicker recovery and clearer thinking after surgery.
Beijing, Beijing MunicipalityAges 18–50 - NCT06467513RecruitingPhase 4
Esketamine for lung problems after heart valve surgery
This study tests whether a medicine called esketamine can help prevent lung problems after heart valve surgery. If you are having valve replacement or repair with a heart-lung machine, you may be able to join.
Zunyi, GuizhouAges 18–75 - NCT06488586Recruiting
Ketamine vs Esketamine for treatment-resistant depression
This trial compares two forms of ketamine—given by IV or as a nasal spray—in people with major depression that hasn't improved after trying at least two other antidepressants. The goal is to see which treatment works better.
Kingston, OntarioAges 18–75 - NCT06579937RecruitingPhase 4
Esketamine for behavior after tonsil surgery in children
This study tests whether a medicine called esketamine can help reduce negative behavior changes in children after tonsillectomy or adenoidectomy surgery. Esketamine is given during anesthesia to see if it helps children recover with fewer emotional or behavioral issues.
Fuzhou, FujianAges 3–7 - NCT06778460Recruiting
Esketamine and lidocaine for pain after liver surgery
This trial tests whether two medicines, esketamine and lidocaine, can reduce long-term pain after liver surgery and possibly improve survival. It is for people who are having a planned liver removal (hepatectomy).
Chengdu, SichuanAges 18–75 - NCT06778811RecruitingPhase 4
Sleep quality study for heart surgery patients
This trial studies sleep problems before and after heart surgery. It tests two medicines to see if they can help improve sleep. This may help you recover better after surgery.
Nanjing, JiangsuAges 40–75 - NCT06788444Recruiting
Esketamine for irritable bowel syndrome with anxiety or depression
This study tests if esketamine, a fast-acting medication, can help people with irritable bowel syndrome who also have anxiety or depression. It is given during a colonoscopy to see if it reduces your IBS symptoms.
Beijing, Beijing MunicipalityAges 18–60 - NCT06890897Recruiting
Esketamine with pulsed radiofrequency for shingles-related face pain
This trial tests whether adding esketamine (a medicine related to ketamine) to a standard nerve treatment (pulsed radiofrequency) can better relieve face pain caused by shingles. It may help if you have ongoing, moderate-to-severe pain in your face or scalp.
BeijingAges 18 years+ - NCT06896994Recruiting
Study of esketamine plus pregabalin and duloxetine for shingles nerve pain
This trial tests whether adding esketamine to two standard pain medicines (pregabalin and duloxetine) can better treat nerve pain from shingles that persists for months. It's for people whose pain hasn't improved enough with pregabalin alone.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07002684Recruiting
Esketamine study for depression
This trial tests how treatment with esketamine affects metabolism in people with depression. It may help if you have not responded to at least two standard antidepressants.
ZagrebAges 18–70 - NCT07002723Recruiting
Esketamine and dexmedetomidine for better sleep after hip surgery
This study tests whether combining two medicines (esketamine and dexmedetomidine) can improve sleep quality after hip fracture surgery in older adults. The goal is to help you rest better and recover more comfortably.
Shenzhen, GuangdongAges 65 years+ - NCT07002801Recruiting
Remimazolam and Esketamine for Older Adults Having Painless Stomach and Colon Scope
This trial tests a combination of two sedative medicines (Remimazolam and Esketamine) for elderly patients having a painless stomach and colon exam. The goal is to see if this combination is safe and effective for older adults.
Harbin, HeilongjiangAges 65 years+ - NCT07146503Recruiting
Esketamine Nasal Spray for Treatment-Resistant Depression in Real Life
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
Genova, GeAges 18–74 - NCT07230171Recruiting
Short-term S-ketamine for fibromyalgia pain relief
This trial tests if low-dose S-ketamine, given as a short intravenous infusion, can safely improve fibromyalgia pain and other symptoms for people who haven't gotten enough relief from non-drug treatments. S-ketamine is a fast-acting medicine that blocks pain signals and may help reset how the brain processes pain.
BeijingAges 18 years+ - NCT07317206RecruitingPhase 2
Ayahuasca vs Esketamine for PTSD
This trial tests two treatments—ayahuasca and esketamine—to see if they can help people with PTSD. It's for people who have PTSD and no other health problems.
Ribeirão Preto, São PauloAges 18–65 - NCT07317219Recruiting
Ayahuasca and esketamine on body image
This study tests how ayahuasca and esketamine affect how you see your body. Healthy volunteers are needed to help learn more.
Ribeirão Preto, São PauloAges 18–65 - NCT07317232Recruiting
Ayahuasca and Esketamine for Premenstrual Symptoms
This trial is testing whether a plant-based medicine called ayahuasca and a nasal spray (esketamine) can help with premenstrual symptoms. It's only for healthy people without any medical conditions.
Ribeirão PretoAges 18–65 - NCT07324057Recruiting
Medication before surgery to reduce autism-related anxiety in children
This trial tests whether a nose spray given before anesthesia can help children with autism feel calmer and have fewer behavior problems after surgery. It compares two medications, dexmedetomidine and esketamine, to see if they reduce negative post-surgery changes.
Nanjing, JiangsuAges 2–12
Common questions
- Are there clinical trials studying Esketamine?
- Yes. Clin2 currently lists 57 recruiting studies that include Esketamine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Esketamine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Esketamine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Esketamine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.