Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05750992Recruiting
Ultrasound vs surgery guidance for numbing during C-section
This trial compares two ways of placing numbing medicine (with bupivacaine) during a planned C-section: an ultrasound-guided approach versus a surgical approach. It aims to find which method provides better pain control and comfort with fewer problems.
CairoAges 21–35 - NCT05896826Recruiting
Magnetocardiography to better spot heart attack patients
This study tests whether magnetocardiography—a scan that measures heart signals using magnets—can more accurately identify myocardial infarction (heart attack). It may help doctors detect heart attacks faster and more accurately using safer, non-invasive testing.
Jinan, ShandongAges 18–79 - NCT06183528Recruiting
Numbing shot for recovery after hip replacement
This study looks at a special numbing shot around the hip joint to see if it helps people recover faster and feel better after total hip replacement surgery. It may help reduce pain and improve your recovery.
Istanbul, UmraniyeAges 40–85 - NCT06240260Recruiting
TENS unit for pain relief during IUD insertion
This study tests whether a small device called a TENS unit can reduce pain during IUD insertion. The TENS unit sends gentle electrical pulses through pads on your skin to help block pain signals, and you'll be part of a group that uses it during the procedure.
Boston, MassachusettsAges 12–50 - NCT06411054Recruiting
Acupuncture with electrical stimulation for pain during miscarriage procedure
This study tests whether adding a type of acupuncture (Acu-TENS) to standard care can reduce pain during a procedure to remove pregnancy tissue after a first-trimester miscarriage. If you are eligible, you may receive either acupuncture with a mild electrical current or a placebo device during the procedure.
Hong KongAges 18 years+ - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06586840Recruiting
Adding an extra nerve block to knee replacement
This trial tests if adding a special nerve block behind the knee (IPACK) to a standard thigh block helps control pain better after total knee replacement. It may lead to less pain and faster recovery.
AydinAges 18–85 - NCT06626334Recruiting
Blue light for pain and inflammation after rib fractures
This trial tests if wearing blue light can reduce pain and inflammation after breaking one or more ribs. It may help you need less pain medicine and recover faster.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07291388Recruiting
Retrolaminar block for lumbar fusion with multimodal pain control
This study tests whether adding a retrolaminar block (a type of back injection) to standard pain medicines helps reduce pain after lumbar spine fusion surgery. It may help you recover with less need for strong painkillers.
Santiago, Santiago MetropolitanAges 18–75 - NCT06741696Recruiting
Saline rinsing after wisdom tooth removal
This trial tests whether using saline (salt water) at different temperatures after wisdom tooth surgery helps with healing and pain. It could help you recover more comfortably.
Rawalpindi, Punjab ProvinceAges Up to 59 years - NCT06754657RecruitingPhase 4
Comparing pain blocks for rotator cuff surgery recovery
This trial tests two ways of numbing the shoulder during rotator cuff surgery to see which leads to better recovery after outpatient surgery. It compares a single injection with a continuous pump that delivers numbing medicine for a longer time.
SantiagoAges 18–75 - NCT06851910Recruiting
Lacosamide IV for acute trigeminal neuralgia pain
This trial is testing a medication called lacosamide, given through an IV, to treat sudden, severe facial pain attacks in people with trigeminal neuralgia who come to the emergency room. The goal is to see if it helps relieve pain quickly.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06854016Recruiting
Laser therapy for recent ankle sprain
This trial tests if a special laser (LightForce®) can help reduce pain from a lateral ankle sprain that happened within the last 72 hours. It may be a good option if you have moderate to severe pain and want a non-drug treatment.
Cassano d'Adda, MilanoAges 18 years+ - NCT06982625Recruiting
Numbing injection after hip replacement for pain relief
This trial tests whether an injection of numbing medicine near the hip can help control pain after a hip replacement surgery. It may be an option for people who have significant pain after their operation.
ParisAges 18 years+ - NCT07009951Recruiting
Virtual reality during heart device implant
This trial tests if using a virtual reality (VR) headset during pacemaker or defibrillator implant surgery can help reduce pain and anxiety. It may offer a drug-free way to help you feel more comfortable during the procedure.
CosenzaAges 18 years+ - NCT07134660Recruiting
Comparing two numbing medicines for lung surgery pain
This study compares two types of numbing medicine (liposomal vs. hydrochloride bupivacaine) injected near the ribs during lung surgery. The goal is to see which one provides better pain relief after the operation.
ShanghaiAges 18–80 - NCT07200544RecruitingPhase 4
Meloxicam for skin cancer surgery pain
This study tests if meloxicam, an anti-inflammatory painkiller, helps control pain after Mohs surgery for skin cancer. It aims to reduce the need for stronger opioid pain medicines.
Oklahoma City, OklahomaAges 18–110 - NCT07256548Recruiting
Predicting spinal anesthesia duration with machine learning
This trial uses a computer program to predict how long spinal anesthesia will last for patients having knee replacement surgery. It may help doctors plan better care.
Kocaeli, İzmitAges 18 years+ - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07290881Recruiting
Comparing two nerve blocks for hernia surgery pain relief
This trial compares two types of nerve blocks (anterior iliac block and ilioinguinal-iliohypogastric block) to see which provides better pain relief after inguinal hernia surgery. If you are having this surgery, joining could help doctors understand the best way to manage your pain.
Şanliurfa, Hali̇li̇yeAges 18–65 - NCT07348419Recruiting
Pain blocks after single-level lumbar disc surgery
This study compares two types of pain-blocking injections (Quadro-Iliac vs Thoracolumbar Interfascial Plane Block) to see which provides better pain relief after a single-level lumbar disc surgery. If you are having this surgery, the trial may help you have less pain and use fewer pain medicines afterwards.
SamsunAges 18–70 - NCT07348523Recruiting
Comparing two types of back pain blocks after lumbar spine surgery
This trial compares two ways of delivering a pain-blocking injection (erector spinae plane block) after a single-level lower back surgery. The goal is to see which approach provides better pain relief after surgery.
SamsunAges 18–70 - NCT07409753RecruitingPhase 2
How oxytocin affects nerve signals in healthy women
This study tests how a single dose of oxytocin affects nerve signals in your arm. It helps researchers understand how oxytocin might change the way your body senses touch or pain.
LinköpingAges 18–65
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Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 212 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.