Clinical trials
Acute Pain clinical trials
Below are recruiting acute pain clinical trials, each written for real people, not researchers. We’re tracking 202 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06741696Recruiting
Saline rinsing after wisdom tooth removal
This trial tests whether using saline (salt water) at different temperatures after wisdom tooth surgery helps with healing and pain. It could help you recover more comfortably.
Rawalpindi, Punjab ProvinceAges Up to 59 years - NCT07528482Recruiting
Reflexology and cold therapy for chest tube removal pain
This study tests whether foot massage (reflexology) and cold application can reduce pain when chest tubes are removed after heart bypass surgery. Researchers want to see if these complementary techniques help manage discomfort during this procedure.
AnkaraAges 18 years+ - NCT07463430Enrolling by invitationPhase 4
Suzetrigine for pain after non-mastectomy breast surgery
This trial tests a new pain medication, suzetrigine, for people having breast surgery (not mastectomy) who are expected to have moderate pain. It checks if this drug works well compared to standard options.
San Diego, CaliforniaAges 18 years+ - NCT05150795RecruitingEarly Phase 1
Testing pregabalin before surgery versus fentanyl during surgery
This trial compares two medicines used around the time of surgery—pregabalin given by mouth before surgery versus fentanyl given during surgery—to see which better controls pain after the operation. You might join if you’re a generally healthy surgical patient and aren’t using certain related medicines.
CairoAges 21–45 - NCT05263297Recruiting
Testing two ways to reduce anxiety during blood draws
This study compares two combined programs to help children feel less stressed during a blood draw. It uses simple, child-friendly activities to see which approach works better for coping during the procedure.
KaramanAges 8–10 - NCT07409753RecruitingPhase 2
How oxytocin affects nerve signals in healthy women
This study tests how a single dose of oxytocin affects nerve signals in your arm. It helps researchers understand how oxytocin might change the way your body senses touch or pain.
LinköpingAges 18–65 - NCT07348419Recruiting
Pain blocks after single-level lumbar disc surgery
This study compares two types of pain-blocking injections (Quadro-Iliac vs Thoracolumbar Interfascial Plane Block) to see which provides better pain relief after a single-level lumbar disc surgery. If you are having this surgery, the trial may help you have less pain and use fewer pain medicines afterwards.
SamsunAges 18–70 - NCT07348523Recruiting
Comparing two types of back pain blocks after lumbar spine surgery
This trial compares two ways of delivering a pain-blocking injection (erector spinae plane block) after a single-level lower back surgery. The goal is to see which approach provides better pain relief after surgery.
SamsunAges 18–70 - NCT07290881Recruiting
Comparing two nerve blocks for hernia surgery pain relief
This trial compares two types of nerve blocks (anterior iliac block and ilioinguinal-iliohypogastric block) to see which provides better pain relief after inguinal hernia surgery. If you are having this surgery, joining could help doctors understand the best way to manage your pain.
Şanliurfa, Hali̇li̇yeAges 18–65 - NCT07291388Recruiting
Retrolaminar block for lumbar fusion with multimodal pain control
This study tests whether adding a retrolaminar block (a type of back injection) to standard pain medicines helps reduce pain after lumbar spine fusion surgery. It may help you recover with less need for strong painkillers.
Santiago, Santiago MetropolitanAges 18–75 - NCT07271849RecruitingPhase 4
Timing of Nalbuphine for Pain and Blood Pressure in Older Knee Surgery Patients
This study tests whether giving the pain medicine nalbuphine at different times during knee replacement surgery affects blood pressure and pain control in older adults. It may help find the best timing to reduce pain and keep vital signs stable.
Jinan, ShandongAges 65–90 - NCT07200544RecruitingPhase 4
Meloxicam for skin cancer surgery pain
This study tests if meloxicam, an anti-inflammatory painkiller, helps control pain after Mohs surgery for skin cancer. It aims to reduce the need for stronger opioid pain medicines.
Oklahoma City, OklahomaAges 18–110 - NCT07145346Enrolling by invitationPhase 4
Suzetrigine for pain relief after multiple rib fractures
This trial tests a new medicine, suzetrigine, for managing acute pain in adults who have broken three or more ribs from a blunt injury. It aims to see if this painkiller works well and is safe for you.
Orange, CaliforniaAges 18 years+ - NCT07134660Recruiting
Comparing two numbing medicines for lung surgery pain
This study compares two types of numbing medicine (liposomal vs. hydrochloride bupivacaine) injected near the ribs during lung surgery. The goal is to see which one provides better pain relief after the operation.
ShanghaiAges 18–80 - NCT06754657RecruitingPhase 4
Comparing pain blocks for rotator cuff surgery recovery
This trial tests two ways of numbing the shoulder during rotator cuff surgery to see which leads to better recovery after outpatient surgery. It compares a single injection with a continuous pump that delivers numbing medicine for a longer time.
SantiagoAges 18–75 - NCT07009951Recruiting
Virtual reality during heart device implant
This trial tests if using a virtual reality (VR) headset during pacemaker or defibrillator implant surgery can help reduce pain and anxiety. It may offer a drug-free way to help you feel more comfortable during the procedure.
CosenzaAges 18 years+ - NCT06240260Recruiting
TENS unit for pain relief during IUD insertion
This study tests whether a small device called a TENS unit can reduce pain during IUD insertion. The TENS unit sends gentle electrical pulses through pads on your skin to help block pain signals, and you'll be part of a group that uses it during the procedure.
Boston, MassachusettsAges 12–50 - NCT06982625Recruiting
Numbing injection after hip replacement for pain relief
This trial tests whether an injection of numbing medicine near the hip can help control pain after a hip replacement surgery. It may be an option for people who have significant pain after their operation.
ParisAges 18 years+ - NCT06851910Recruiting
Lacosamide IV for acute trigeminal neuralgia pain
This trial is testing a medication called lacosamide, given through an IV, to treat sudden, severe facial pain attacks in people with trigeminal neuralgia who come to the emergency room. The goal is to see if it helps relieve pain quickly.
L'Hospitalet de Llobregat, BarcelonaAges 18 years+ - NCT06721000Enrolling by invitation
Patient-controlled vs. standard epidural pain relief
This trial compares two types of epidural pain management during surgery. It tests whether letting you control your pain medication yourself works better than the standard method.
Karachi, SindhAges 19 years+ - NCT06539741Recruiting
Ibuprofen response study for wisdom tooth removal
This study looks at how people respond to ibuprofen after having one or more impacted wisdom teeth removed. It aims to understand why pain relief varies between individuals.
Philadelphia, PennsylvaniaAges 18 years+ - NCT03725527Recruiting
Nerve block test to improve breathing after belly surgery
This trial studies whether a numbing injection near the abdominal muscle (rectus sheath block) helps your breathing and diaphragm function after elective upper belly surgery. If you qualify, you may receive or not receive this pain/nerve block as part of the study.
Asyut, Assiut GovernorateAges 18–50 - NCT06411054Recruiting
Acupuncture with electrical stimulation for pain during miscarriage procedure
This study tests whether adding a type of acupuncture (Acu-TENS) to standard care can reduce pain during a procedure to remove pregnancy tissue after a first-trimester miscarriage. If you are eligible, you may receive either acupuncture with a mild electrical current or a placebo device during the procedure.
Hong KongAges 18 years+ - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25
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Common questions
- Are there clinical trials for acute pain?
- Yes. Clin2 currently lists 202 recruiting acute pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a acute pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a acute pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.