Advanced or Metastatic Breast Cancer clinical trials

Study of a new drug for advanced solid tumors

This trial tests a new drug (an ATR inhibitor) for people with advanced solid tumors that have not responded to or are not suitable for standard treatments. It aims to see if the drug is safe and effective, and it may be an option if you have good heart function and are feeling well enough to participate.

PLB-002 for advanced solid tumors study

This trial tests a new drug called PLB-002 for people with advanced solid tumors that have stopped responding to standard treatments. It aims to see if the drug is safe and effective, especially for cancers that show a specific marker called CLDN6.

Furmonertinib plus radiation and chemo for EGFR lung cancer with brain spread

This trial tests a combination of a targeted pill (furmonertinib), chemotherapy into the spinal fluid, and precise radiation for people with a specific type of lung cancer (EGFR-mutant adenocarcinoma) that has spread to both the brain and the lining around the brain. The goal is to see if this combination can better control the cancer and improve symptoms.

Study of ZX-8177 for advanced solid tumors

This trial tests a new oral drug (ZX-8177) for people with advanced solid tumors that have stopped responding to standard treatments or cannot be treated with standard options. The goal is to see if it is safe and helps control the disease.

Testing LM103 for advanced melanoma

This trial tests a new drug called LM103 for people with advanced melanoma who have already tried several standard treatments, including immunotherapy. The goal is to see if LM103 can help shrink tumors when other treatments have stopped working.

Long-term study of levodopa gel for advanced Parkinson's

This trial tests how well a levodopa-entacapone-carbidopa intestinal gel works over time for people with advanced Parkinson's disease who have severe motor fluctuations and dyskinesia. It's for those who've already used a similar treatment (foslevodopa) for at least a month and whose doctor decided to start this gel.

Salvage radiation with hormone therapy for prostate cancer recurrence

This trial tests how well salvage radiation therapy works for prostate cancer that has come back after surgery. It looks at whether adding hormone therapy based on PSA response improves outcomes.

Treating blood clots in the lung at home for cancer patients

This study tests whether people with active cancer and a new blood clot in the lung can be safely treated at home instead of in the hospital. If you have cancer and a blood clot that is not causing severe symptoms, you may be able to join this trial.

Testing ABP1011T for advanced solid tumors

This trial tests an experimental pill called ABP1011T for people with advanced solid tumors that are no longer responding to standard treatments. It is especially focused on small cell lung cancer and other cancers that might be sensitive to this drug. The goal is to see if the pill can shrink tumors or slow their growth.

Neoadjuvant drug combo for stage 3 EGFR-mutant lung cancer

This trial tests two drugs, sacituzumab tirumotecan and limertinib, given before surgery to people with stage 3 non-small cell lung cancer that has an EGFR mutation. The goal is to see if this combination can shrink the tumor enough to allow surgery.

Mobithron Advance for knee osteoarthritis: long-term effects

This trial tests a supplement called Mobithron Advance to see if it can slow down knee osteoarthritis over time. It may help people with mild to moderate knee arthritis find a non-surgical option.

Study of MHB009C for advanced solid tumors

This trial tests a new drug called MHB009C for people with advanced solid tumors that have not responded to other treatments. The goal is to see if the drug is safe and effective.

Study of GW5282 for advanced solid tumors

This trial tests a new oral drug, GW5282, for people with advanced solid tumors that have stopped responding to standard treatments. The goal is to see if this drug can shrink tumors or stop them from growing.

LBL-024 combo for advanced esophageal cancer

This trial tests a new drug combination for advanced solid tumors, specifically esophageal cancer. It may help people whose cancer has not responded to other treatments.

Electro-acupuncture for advanced lung cancer: the EALER study

This study tests whether adding electro-acupuncture (a gentle type of acupuncture with mild electrical pulses) to standard first-line immunotherapy and chemotherapy can help people with advanced non-small cell lung cancer. It aims to see if this combination improves quality of life and overall treatment outcomes.

Testing 68Ga-FAPI PET scan in biliary cancers

This trial is testing a new type of PET scan (called 68Ga-FAPI) to see if it can better detect biliary tract cancers, including advanced or recurring gallbladder cancer and intrahepatic cholangiocarcinoma. It may help doctors find cancer more accurately, which could guide better treatment decisions.

Testing TQB3142 in advanced tumors

This trial tests a new drug called TQB3142 in people with advanced cancers that have not responded to standard treatments. The goal is to find a safe dose and see how the drug works in the body.

A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies

Testing BGM-2121 for advanced solid tumors

This study tests an experimental drug called BGM-2121 for people with advanced solid tumors that have not responded to or stopped responding to standard treatments. The goal is to see if the drug is safe and if it can shrink tumors.

Study of MG2512 for advanced solid tumor patients

This trial tests a new drug called MG2512 for people with advanced solid tumors that have not responded to standard treatments or who cannot take standard therapy. The study aims to understand if MG2512 is safe and effective.

Study of PARG inhibitor FORX-428 for advanced solid tumors

This trial tests a new drug called FORX-428, which targets a protein called PARG, in people with advanced solid tumors. It is for patients whose cancer has not responded to prior treatments and who have specific genetic changes, such as BRCA mutations.

Testing a new drug before surgery for lung cancer

This trial studies whether a new drug called Ivonescimab can improve outcomes when given before surgery for non-small cell lung cancer. It may help shrink tumors and make them easier to remove.

SPR1020 for advanced solid tumors with DNA repair defects

This trial tests an experimental drug (SPR1020) for people with advanced solid tumors that have not responded to standard treatments, especially those with BRCA or related gene mutations. The drug is taken by mouth and the study aims to find the right dose and see if it helps shrink tumors.

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors