Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT07509125Recruiting
Ultra-high resolution PET brain scans for aging, dementia, and psychosis
This study uses a new ultra-high resolution PET scanner to look at brain changes in healthy aging, dementia, ALS, movement disorders, and psychosis. It aims to better understand these conditions and improve imaging techniques.
Leuven, Vlaams-BrabantAges 18–90 - NCT06765564Recruiting
Study of stem cell therapy for amyotrophic lateral sclerosis (ALS) progression
This study tests whether a new treatment using special motor neuron cells made from stem cells (iPSCs) can help people with ALS. The cells will be transplanted into the spinal cord to try to slow the disease and improve function.
Shanghai, Shanghai MunicipalityAges 18–60 - NCT07467187Recruiting
Home Ventilation with Tracheostomy in Denmark (2016–2025)
This study looks at people in Denmark who need a home ventilator through a tracheostomy. It aims to understand their care and outcomes over several years.
CopenhagenAges Any age - NCT07454733Recruiting
Do videos of clinic meetings improve quality of life in ALS?
This study looks at whether watching videos of your clinic team meetings helps improve quality of life for people with ALS and their caregivers. You and your caregiver would both take part, and you'd need to be able to use the internet and email.
Scottsdale, ArizonaAges 18 years+ - NCT05852418Recruiting
Registry study of devices, medicines, and care in ALS and SMA
This study collects information in a registry about assistive devices, medicines, and healthcare support for people with long-term neurological conditions like ALS and SMA. It may help researchers understand what treatments and supports are used and how they relate to patients’ needs over time.
BerlinAges 18 years+ - NCT06396260Recruiting
Brain network study in ALS with emotional outbursts
This study looks at how ALS affects the brain's structure and networks, especially in people who have sudden emotional outbursts (pseudobulbar affect). You will have brain scans (MRI and MEG) and answer questions to help researchers understand these changes.
Aalborg, Northern JutlandAges 18–90 - NCT06810219Recruiting
Brain-computer interface study for ALS communication
This study tests a brain-computer interface (BCI) that uses augmented reality glasses to help people with late-stage ALS communicate. You wear a headset that reads your brain signals and lets you select words or phrases on a screen, giving you a new way to talk to others.
Santa Barbara, CaliforniaAges 18 years+ - NCT07407725Recruiting
Study of brain-computer interface use in ALS, spinal cord injury, and healthy adults
This study tests how well people with ALS, spinal cord injury, or healthy volunteers can use a brain-computer interface (BCI). The goal is to learn how to measure what the device can do, which may help people with severe communication or movement limitations.
Chicago, IllinoisAges 18 years+ - NCT07380204Recruiting
Measuring Hsp90 in the brain with a PET scan
This study uses a special PET scan to measure a protein called Hsp90 in the brain. It aims to understand how Hsp90 levels differ in healthy people and those with Parkinson's, Alzheimer's, or ALS, which may lead to new treatments.
Leuven, Vlaam-BrabantAges 18–70 - NCT07357428Recruiting
Brain-computer implant study for severe paralysis or speech loss
This study tests a brain-computer implant that might help people with severe paralysis or speech loss control a computer with their thoughts. It is for people who have trouble moving and speaking due to a progressive disease or injury.
Sacramento, CaliforniaAges 22–75 - NCT06203106Recruiting
NYSCF Scientific Discovery Biobank
This study collects blood, saliva, or skin samples from people with certain neurological conditions and from healthy volunteers to help researchers better understand and find treatments for these diseases.
New York, New YorkAges 4 weeks+ - NCT00801333Recruiting
Create patient-specific stem cells for research
This study uses adult body cells (from participants) to create special lab cells called stem cells for research. It’s mainly about whether cells can be made and studied, not about treating a disease.
JerusalemAges 18 years+ - NCT07334743Recruiting
A study to find biomarkers in ALS using tiny brain particles
This trial collects blood and spinal fluid samples from people being checked for ALS. The goal is to find clues (biomarkers) in tiny particles from nerve cells that could help doctors better understand and diagnose ALS.
ParisAges 18 years+ - NCT07322003RecruitingPhase 3
Pridopidine for ALS: Phase 3 trial testing safety and effectiveness
This trial is testing if an oral medication called pridopidine can slow the progression of ALS. It is for people recently diagnosed with ALS who have mild to moderate breathing function and meet specific risk scores.
Phoenix, ArizonaAges 18–80 - NCT07312240Recruiting
Biomarkers in ALS: A long-term study
This study is looking for people with ALS to help doctors understand how certain biological markers (biomarkers) change over time. It involves a lumbar puncture (spinal tap) to collect fluid from your spine and regular check-ups.
Milan, LombardyAges 18 years+ - NCT06829212Recruiting
Wireless brain implant for device control
This trial tests a wireless brain implant that lets you control external devices like a computer or wheelchair just by thinking. It's designed for people with paralysis or double arm amputations who want to regain some independence.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07298486Enrolling by invitation
Robotic glove to help with grip and hand function in ALS
This trial tests whether a robotic glove can improve quality of life, grip strength, and fine motor control in people with ALS. If you have trouble with hand strength or dexterity, this device may help you regain some function.
Davie, FloridaAges 18–99 - NCT07302321Recruiting
Needs of ALS patients with C9orf72 mutation and their caregivers
This study asks people with ALS who have a specific genetic change (C9orf72) and their caregivers to fill out an online survey. It aims to better understand their needs so that support can be improved.
Milan, LombardyAges 18 years+ - NCT06849609RecruitingEarly Phase 1
Gene therapy VGN-R13 for ALS safety and tolerability
This study tests a new gene therapy called VGN-R13 for people with ALS. It aims to see if the treatment is safe and tolerable, and if it can slow down the disease. You may be able to join if your ALS symptoms started recently and your lung function is still fairly good.
Wuhan, HubeiAges 18 years+ - NCT07292545Recruiting
Video exercise program for balance and coordination in ALS
This study tests whether a video-guided exercise program for body awareness and movement control can help people with ALS improve their balance and daily function. It may be an option if you can sit up on your own and don't have other nerve or muscle problems.
Mersin, TARSUSAges 18–70 - NCT07294144RecruitingPhase 2
Tofersen for ALS without SOD1 or FUS mutations
This trial tests if tofersen, a drug that targets a protein linked to ALS, can help people who have ALS but do not have mutations in the SOD1 or FUS genes. It aims to slow disease progression in those diagnosed within the last 2 years.
Atlanta, GeorgiaAges 18 years+ - NCT06803784Recruiting
Bioproducts in body fluids for early brain disease detection
This study is looking for proteins in blood and other body fluids that could help detect brain diseases like Parkinson's, Alzheimer's, and ALS early. It aims to improve diagnosis and future treatments.
Pozzilli, ItalyAges 20 years+ - NCT07287397RecruitingPhase 1/Phase 2
Testing VTx-002 for safety in ALS patients
This trial tests a new drug called VTx-002 to see if it is safe and tolerable for people with ALS. You may be able to join if you have had symptoms for less than 18 months and have a caregiver who can help.
Phoenix, ArizonaAges 18 years+
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 186 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.