Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 186 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07202494Recruiting
Brain aging and resilience MRI study
This study uses powerful MRI scans to understand how the brain ages and why some people stay healthy while others develop neurological diseases like multiple sclerosis or Alzheimer's. It compares healthy volunteers to people with certain conditions, and all participants get a detailed brain MRI.
MarseilleAges 18–90 - NCT07871071Recruiting
Brain-computer interface communication device for ALS
This trial tests a brain-computer interface (BCI) device that lets people with ALS communicate using brain signals, without needing to move. It may help those who have difficulty speaking or using eye-gaze devices.
Santa Barbara, CaliforniaAges 18 years+ - NCT03366506Recruiting
Study factors linked to ALS development
This study looks at people who might have amyotrophic lateral sclerosis (ALS) to understand what factors are associated with how the condition starts and develops. If you have a suspected or confirmed ALS diagnosis, it may help researchers learn what influences ALS and potentially guide future prevention or care.
JerusalemAges 12–120 - NCT05136222Recruiting
Testing a night breathing machine setting for muscle-nerve disease
This study helps find the best night-time settings for a non-invasive breathing support device (a machine that helps breathing without a tube). It may help people with motor neurone disease start long-term breathing support more comfortably and effectively.
AdelaideAges 18 years+ - NCT05663008Recruiting
Testing nerve-to-muscle signal changes to diagnose movement diseases
This study measures how nerves communicate with muscles, using recordings and gels. It aims to spot early, personalized signs of conditions like ALS and related diseases, and to improve diagnosis.
Dublin, LeinsterAges 18 years+ - NCT05923905RecruitingPhase 4
Study of FB1006 for people with early ALS
This trial tests whether FB1006 is safe and works better than usual care for treating amyotrophic lateral sclerosis (ALS). It focuses on people with relatively early ALS and good breathing function.
Beijing, Beijing MunicipalityAges 18–80 - NCT06337578Recruiting
Telephone-based cognitive screening study
This study tests if a phone-based cognitive screening can effectively assess thinking and memory. It may help people who can't easily visit a clinic.
MilanAges 18–100 - NCT07844590Recruiting
Early breathing problem detection in ALS
This study tests new ways to find breathing problems early in people with ALS. It uses MRI scans and other checks to see how the disease affects breathing muscles, which could help doctors treat symptoms sooner.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07836751Recruiting
Eye-controlled device for neck weakness
This study tests a device that lets you control head and neck movements using your eyes. It's designed to help people with neck weakness (head drop) move their heads more easily by looking in the direction they want to go.
Salt Lake City, UtahAges 18 years+ - NCT07823101Recruiting
Imaging study of swallowing and speech muscles in muscle diseases
This study uses imaging to look at the muscles involved in swallowing and speaking in people with certain muscle diseases, like inclusion body myositis or ALS. The goal is to better understand these conditions, which might help improve care in the future.
Baltimore, MarylandAges 18 years+ - NCT07818772Recruiting
Using powerful MRI scans to find markers in motor neuron disease
This study uses a very powerful MRI scanner (7T) to take detailed pictures of the brain and spinal cord in people with motor neuron disease. The goal is to find non-invasive markers that could help diagnose and monitor the disease.
GlasgowAges 18 years+ - NCT06219759Recruiting
Nerve Reconnection and Signals in ALS
This study looks at how nerves reconnect and send signals to muscles in people with ALS. It may help doctors understand the disease better and find new ways to treat it.
Aarhus, Central JutlandAges 18 years+ - NCT05983211Recruiting
TMS therapy study for ALS patients
This trial tests whether repetitive TMS (transcranial magnetic stimulation) can help people with ALS. It uses a special type of TMS that is repeated and measured. You would lie comfortably for about an hour while receiving the treatment.
Toronto, OntarioAges 18 years+ - NCT07743268Enrolling by invitationPhase 1/Phase 2
Personalized gene therapy for ALS linked to TARDBP
This trial tests a personalized medicine approach for people with ALS caused by changes in the TARDBP gene. The treatment uses a custom-made molecule to target the genetic cause and may help slow the disease.
St Louis, MissouriAges Any age - NCT07703462Enrolling by invitationPhase 1/Phase 2
Personalized therapy for TARDBP ALS
This trial offers a custom-made treatment for people with ALS caused by a TARDBP gene mutation. It uses a personalized medicine approach to target the specific genetic cause of the disease.
Philadelphia, PennsylvaniaAges Any age - NCT06598202RecruitingPhase 1/Phase 2
Nasal Drop Therapy for ALS
This trial tests a nasal drop made from tiny cell particles (extracellular vesicles) for ALS. The goal is to see if it's safe and if it can slow down the disease. It may be an option if your ALS is in the early to moderate stage.
Beijing, Beijing MunicipalityAges 18–80 - NCT07674667RecruitingPhase 1/Phase 2
Testing a treatment to restore UNC13A function in ALS
This trial tests a new treatment aimed at restoring the function of a gene called UNC13A in people with ALS. It involves multiple clinic visits, MRI scans, and spinal taps to see if the treatment is safe and may slow the disease.
Lübeck, Schleswig-HolsteinAges 18–75 - NCT06681610Recruiting
Testing pulse stimulation to improve movement in ALS
This trial studies if a non-invasive pulse stimulation can help people with ALS move better. It aims to see if this treatment can improve motor function.
Barcelona, CataloniaAges 21–80 - NCT05632757Recruiting
Studying support for ALS patients and their family caregivers
This study looks at how much burden (stress and day-to-day strain) ALS creates for both the patient and the main caregiver. It may help shape better ways to support families facing ALS over time.
MarseilleAges 18 years+ - NCT05995782RecruitingPhase 1
Testing safety of FB418 in healthy people
This trial studies a new drug called FB418 to see if it's safe and how the body handles it. It first tests single doses in younger healthy men, then multiple doses, and also includes an optional group for healthy older adults.
SeoulAges 19 years+ - NCT07595666Enrolling by invitation
New PET scanner versus standard PET for head and neck imaging
This study compares a newer PET/CT scanner (called NeuroEXPLORER) with standard PET/CT scanners for imaging the head and neck region. The goal is to see if the new scanner provides better or clearer images to help diagnose conditions.
Leuven, Vlaams-BrabantAges 4 weeks+ - NCT07567664Enrolling by invitation
Brain Changes in Neurodegenerative Diseases: A Tracking Study
This research study tracks how brain damage progresses in rare neurodegenerative diseases like frontotemporal dementia, primary progressive aphasia, PSP, CBS, and ALS. Researchers use brain imaging and tests to understand how these diseases spread in the brain, which could help develop better treatments.
Milan, LombardyAges 20–85 - NCT06528964Recruiting
Skin protein study for Alzheimer's, Parkinson's, and related disorders
This study looks at the skin of people with memory or movement disorders (like Alzheimer's, Parkinson's, ALS) to find proteins that may help diagnose these conditions. If you have one of these diseases or are a healthy older adult, you may be able to join by giving a small skin sample.
San Luis Potosí CityAges 45 years+ - NCT07533903Recruiting
Brain-Computer Interface for Arm Control in Paralysis
This trial tests a surgically implanted brain-computer interface (BCI) device designed to help people with severe arm paralysis—from conditions like ALS or stroke—regain some ability to control their arms. The device reads signals from your brain and translates them into arm movements, potentially helping you perform daily activities.
MelbourneAges 21 years+
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 186 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.