Clinical trials
Amyotrophic Lateral Sclerosis clinical trials
Below are recruiting amyotrophic lateral sclerosis clinical trials, each written for real people, not researchers. We’re tracking 189 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06249867RecruitingPhase 2
Darifenacin for ALS: safety and effect
This trial tests whether darifenacin, a drug currently used for bladder control, can safely help people with ALS. It aims to understand how the drug works in the body and if it can slow the disease or relieve symptoms.
Ottawa, OntarioAges 18–85 - NCT06266403Recruiting
Studying how people with ALS communicate in conversations
This study looks at how people with ALS and their conversation partners talk with each other. It aims to understand changes in speech and find better ways to support communication.
University Park, PennsylvaniaAges 18–90 - NCT06280079Recruiting
High-calorie fatty diet for ALS patients
This trial tests a very high-calorie, fatty diet to see if it helps people with ALS. If you have been diagnosed recently and are not too advanced in the disease, this special diet may give your body extra energy to slow progression.
AachenAges 18 years+ - NCT06318585Recruiting
Building a database for motor neuron disease research
This study collects information from people with ALS or other motor neuron diseases to better understand how these conditions vary. By joining a database, you help researchers find patterns that could improve care.
Milan, MIAges 18 years+ - NCT06337578Recruiting
Telephone-based cognitive screening study
This study tests if a phone-based cognitive screening can effectively assess thinking and memory. It may help people who can't easily visit a clinic.
MilanAges 18–100 - NCT06363357Recruiting
Shoulder brace study for arm weakness from nerve or muscle diseases
This study tests a fabric shoulder brace that moves like a muscle. It may help people with nerve or muscle diseases improve arm movements like reaching and lifting.
Seoul, Jongno-guAges 10 years+ - NCT06396260Recruiting
Brain network study in ALS with emotional outbursts
This study looks at how ALS affects the brain's structure and networks, especially in people who have sudden emotional outbursts (pseudobulbar affect). You will have brain scans (MRI and MEG) and answer questions to help researchers understand these changes.
Aalborg, Northern JutlandAges 18–90 - NCT06429735Recruiting
Robot-implanted brain-computer interface for severe paralysis
This trial tests a brain-computer interface (a device that lets you control a computer with your thoughts) that is implanted by a robot. It is for people with severe paralysis who may benefit from a new way to communicate or control devices.
Phoenix, ArizonaAges 22–75 - NCT06491732Recruiting
Muscle Scan as an ALS Biomarker
This study tests a device called Myolex mScan that measures muscle health non-invasively in people with ALS. It aims to see if this can be a useful biomarker to track the disease progression.
Phoenix, ArizonaAges 18 years+ - NCT06527222RecruitingPhase 2
Ranolazine for muscle cramps in ALS
This trial tests if a heart medication called ranolazine can reduce painful muscle cramps in people with ALS. If you experience frequent cramps and meet the other criteria, this study may be an option for you.
San Francisco, CaliforniaAges 18 years+ - NCT06528964Recruiting
Skin protein study for Alzheimer's, Parkinson's, and related disorders
This study looks at the skin of people with memory or movement disorders (like Alzheimer's, Parkinson's, ALS) to find proteins that may help diagnose these conditions. If you have one of these diseases or are a healthy older adult, you may be able to join by giving a small skin sample.
San Luis Potosí CityAges 45 years+ - NCT06539169Recruiting
Following people with rare diseases over time
This study follows people with rare diseases over time to learn more about how these conditions progress and how they are treated. Joining may help researchers understand your disease better and find better ways to care for others.
Los Altos, CaliforniaAges Any age - NCT06566651Recruiting
Emotion processing study for people with ALS
This study looks at how people with ALS process emotions. It compares ALS patients, people with other nerve-muscle diseases, and healthy volunteers to understand changes in emotional processing.
Aarhus, Central JutlandAges 18 years+ - NCT06581861Recruiting
Family study to prevent ALS and FTD
This study is for adults who have a strong family history of ALS or FTD (like a parent or sibling with the disease) to help researchers understand how to prevent these conditions. It involves following you for about a year to track your health.
Birmingham, AlabamaAges 18 years+ - NCT06596746Recruiting
Tracking markers for neurodegenerative diseases
This study tracks changes in people with Parkinson's disease, other movement disorders, or cognitive decline to find better ways to measure disease progression.
Cassino, FrosinoneAges 10 years+ - NCT06598202RecruitingPhase 1/Phase 2
Nasal Drop Therapy for ALS
This trial tests a nasal drop made from tiny cell particles (extracellular vesicles) for ALS. The goal is to see if it's safe and if it can slow down the disease. It may be an option if your ALS is in the early to moderate stage.
Beijing, Beijing MunicipalityAges 18–80 - NCT07521930Recruiting
Brain implant to restore communication and movement control
This trial tests a surgically implanted brain device designed to help people with severe paralysis or movement disorders regain the ability to communicate and control their limbs. The device reads signals from your brain and translates them into commands that could help you interact with computers or assistive technology.
Baltimore, MarylandAges 18–80 - NCT06665165RecruitingPhase 1
Study of AMX0114 for people with ALS
This study tests an experimental drug called AMX0114 for people recently diagnosed with ALS. It is an early-phase trial to see if the drug is safe and how it affects the body.
La Jolla, CaliforniaAges 18 years+ - NCT06671236RecruitingPhase 1
Treg cell therapy for ALS
This trial tests a new type of cell therapy called regulatory T cells (Tregs) for people with neurodegenerative diseases like ALS. The goal is to see if these cells can slow down the disease.
Zhengzhou, HenanAges 18–70 - NCT06681610Recruiting
Testing pulse stimulation to improve movement in ALS
This trial studies if a non-invasive pulse stimulation can help people with ALS move better. It aims to see if this treatment can improve motor function.
Barcelona, CataloniaAges 21–80 - NCT06700304Recruiting
Brain implant to help control devices with thoughts
This clinical trial tests a brain-computer interface (a small device implanted in the brain) that may help people with severe paralysis control external devices like a computer or tablet using only their thoughts. The study is for adults with paralysis from a spinal cord injury or ALS, and requires a stable caregiver.
Toronto, OntarioAges 19 years+ - NCT07213440Recruiting
Early markers for ALS study
This study looks for early signs of ALS in people with genetic risk, healthy controls, and people with early symptoms. It aims to find markers that could help diagnose ALS sooner.
Tours, FranceAges 18–90 - NCT06765499Recruiting
Silkworm pupa powder for nutrition and frailty in motor neuron disease
This trial tests whether silkworm pupa powder can improve nutrition and reduce frailty in people with motor neuron disease (like ALS). It looks for volunteers who are frail, have a confirmed diagnosis, and are willing to provide blood, stool, and urine samples.
Hangzhou, ZhejiangAges 18–80 - NCT06803784Recruiting
Bioproducts in body fluids for early brain disease detection
This study is looking for proteins in blood and other body fluids that could help detect brain diseases like Parkinson's, Alzheimer's, and ALS early. It aims to improve diagnosis and future treatments.
Pozzilli, ItalyAges 20 years+
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Common questions
- Are there clinical trials for amyotrophic lateral sclerosis?
- Yes. Clin2 currently lists 189 recruiting amyotrophic lateral sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amyotrophic lateral sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.