Clinical trials
Anterior Cruciate Ligament (ACL) Reconstruction clinical trials
Below are recruiting anterior cruciate ligament (acl) reconstruction clinical trials, each written for real people, not researchers. We’re tracking 114 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05342441Recruiting
Choosing the best ligament graft for ACL repair
This study looks at how different “grafts” (tissue used to rebuild the ACL) affect outcomes after first-time ACL reconstruction. It may help personalize graft choice for people who want to return to physical activity.
HvidovreAges 18–40 - NCT05391672Recruiting
Study for early surgery after a partial ACL tear
This trial looks at treatment options for people with a partial ACL ligament tear in the knee, including both recent and long-standing injuries. It may help to clarify the best early approach for healing and knee function, especially when there are no other ligament injuries.
AsyutAges 15–50 - NCT05461326Recruiting
Compare two tendon grafts for ACL surgery recovery
This study compares two ways to rebuild the ACL using different tendon grafts (quadriceps tendon vs patellar tendon) taken from your own body. It aims to learn which option leads to better recovery after ACL reconstruction, including strength and function.
Birmingham, AlabamaAges 14–65 - NCT05747079Recruiting
Early versus delayed surgery after a new ACL tear
This study compares immediate surgery versus waiting a short time for people with a new ACL injury. It aims to see which timing leads to better recovery and knee function.
LeuvenAges 16 years+ - NCT05754632Recruiting
Blood flow restriction exercises after ACL surgery in teens
This trial tests whether a special type of exercise that uses a cuff (blood flow restriction training, or BFRT) can help teens recover after ACL reconstruction. It’s designed to see if adding BFRT to standard rehab improves strength and return to sport.
Farmington, ConnecticutAges 12–18 - NCT05949177Recruiting
Mindfulness and graded exercise for fear after ACL surgery
This trial studies whether a combination of mindfulness practice and a step-by-step return-to-activity plan can reduce fear and improve recovery after ACL reconstruction. It may help people who feel worried about re-injury and want a structured way to get back to sports.
Chapel Hill, North CarolinaAges 14–35 - NCT05953051Recruiting
ACL surgery with a tunnel widened using enriched bone
This trial compares two techniques for ACL reconstruction—one uses an enriched, patient’s own bone during surgery and the other uses the standard approach. It may help researchers understand whether the enriched bone method improves knee healing and function.
ZurichAges 18–50 - NCT05985629RecruitingPhase 4
Numbing shot behind the knee for ACL surgery pain
This study tests whether an extra numbing shot (called IPACK) behind the knee helps reduce pain and the need for strong pain medicine after ACL reconstruction surgery. It's for patients who are having their first ACL surgery and are not using a donor graft.
Maywood, IllinoisAges 16 years+ - NCT06147427Recruiting
ACL reconstruction with or without Lemaire procedure
This study compares two surgical techniques for repairing a torn ACL: standard ACL reconstruction alone versus ACL reconstruction plus a Lemaire procedure (an extra side-stabilizing repair). It aims to see which approach provides better knee stability for active patients over at least 2 years.
LyonAges 18–50 - NCT06190223Recruiting
ACL repair using kneecap tendon with press-fit method
This study looks at a specific ACL reconstruction technique using a graft from your kneecap tendon that is fixed with a press-fit method. It aims to determine how well patients recover after at least one year.
AnkaraAges 18–55 - NCT06194682Recruiting
ACL reconstruction follow-up study
This study follows people who have had or will have ACL reconstruction surgery at this hospital. It helps doctors learn more about how patients recover after ACL surgery over the long term.
MilanAges 18–65 - NCT06206200Recruiting
Thinking and moving after ACL surgery
This study looks at how doing a thinking task at the same time as a walking or balance task affects recovery in people who have had ACL reconstruction surgery. It may help you understand what to expect during later stages of rehab.
Roeselare, West-VlaanderenAges 18–40 - NCT06294314Recruiting
ACL surgery with bone marrow and internal brace for return to sports
This trial studies a new way to reconstruct a torn ACL using your own bone marrow cells and a special internal brace to help you return to sports. It's for young athletes who haven't had ACL surgery before.
Huntington, West VirginiaAges 14–26 - NCT06311513RecruitingPhase 4
Concentrated bone marrow injection during repeat ACL surgery
This study tests whether adding a concentrated bone marrow injection during repeat ACL surgery helps healing and recovery better than surgery alone. If you have had a previous ACL reconstruction that failed, you may be eligible.
Atlanta, GeorgiaAges 18–55 - NCT06341192Recruiting
Comparing two ways to reconstruct the ACL
This trial compares two different techniques for ACL surgery (single bundle vs. double bundle) to see which one works better. If you're planning to have ACL surgery, you may be able to join.
Taoyuan, taoyuanAges 18 years+ - NCT06341868Recruiting
Electrical stimulation for ACL recovery in military cadets
This trial tests whether a special electrical stimulation device (KneeStim) can help military academy cadets recover faster after ACL reconstruction surgery. It aims to improve muscle strength and knee function using gentle electrical pulses during rehabilitation.
West Point, New YorkAges 17–27 - NCT06357091Recruiting
ACL repair with Shark Screw or standard screw
This trial compares two types of screws used to hold a new ACL in place: a Shark Screw and a standard biocomposite screw. It may help if you have a torn ACL that needs surgery.
Schwaz, TyrolAges 18 years+ - NCT06368544Recruiting
Early walking training after ACL knee surgery
This trial studies whether starting walking exercises earlier after ACL reconstruction can help protect the knee cartilage from wearing down. It may be a good fit if you are having your first ACL surgery at Peking University Third Hospital and your knee has already healed from the initial injury.
BeijingAges 18–40 - NCT06430775Recruiting
Long-term ACL recovery after surgery
This study is looking at how well the ACL heals after surgery in the long term. It helps researchers understand recovery patterns, so you may get a closer look at your knee's healing process.
Roeselare, West-VlaanderenAges 18–40 - NCT06442319Recruiting
PRP after ACL reconstruction
This trial tests if injecting platelet-rich plasma (a concentration of your own blood platelets) after ACL reconstruction helps with healing and reduces pain. It's for people who recently had ACL surgery and want to try an extra treatment to improve recovery.
TorunAges 18–45 - NCT06456268Recruiting
VibraCool to reduce pain and opioid use after ACL surgery
This trial tests a device called VibraCool to see if it can reduce pain and the need for opioid painkillers after ACL reconstruction surgery.
New York, New YorkAges Any age - NCT06505525Recruiting
ACL reconstruction: adding extra support vs standard surgery
This trial compares two surgical techniques for ACL reconstruction. The standard method repairs the ACL inside the knee joint, while the new method also adds extra support outside the joint. The study aims to see which approach gives better stability and recovery for people with specific risk factors, like being a young athlete or having a chronic ACL tear.
São Paulo, São PauloAges 14–40 - NCT06511232RecruitingPhase 4
Morphine in bone for ACL surgery pain
This trial tests if giving morphine directly into the bone during ACL reconstruction can reduce pain after surgery. It may help patients who are having a specific type of ACL repair using their own patellar tendon.
Houston, TexasAges 18–40 - NCT06529692Recruiting
Split-belt treadmill training after ACL reconstruction
This study tests whether walking on a special split-belt treadmill (where each belt moves at a different speed) can help improve how your knee moves and feels after ACL reconstruction. The goal is to see if this training leads to better long-term knee health.
Ann Arbor, MichiganAges 14–45
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Common questions
- Are there clinical trials for anterior cruciate ligament (acl) reconstruction?
- Yes. Clin2 currently lists 114 recruiting anterior cruciate ligament (acl) reconstruction studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anterior cruciate ligament (acl) reconstruction trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anterior cruciate ligament (acl) reconstruction trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Anterior Cruciate Ligament Reconstruction
- Anterior Cruciate Ligament Reconstruction Rehabilitation
- ACL - Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament (ACL) Tear
- Anterior Cruciate Ligament Injuries
- Anterior Cruciate Ligament Rupture
- Anterior Cruciate Ligament Tear
- Anterior Cruciate Ligament
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.