Clinical trials
Aortic Stenosis Disease clinical trials
Below are recruiting aortic stenosis disease clinical trials, each written for real people, not researchers. We’re tracking 152 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT04204915Recruiting
Early valve replacement for severe but symptom-free aortic narrowing
This study looks at whether replacing a narrowed heart valve early helps people who have severe aortic stenosis but no symptoms. You would be randomly assigned to early valve replacement or careful waiting with regular check-ups.
Garran, Australian Capital TerritoryAges 18 years+ - NCT04968509RecruitingPhase 3
PCSK9 shots for calcified aortic valve narrowing
This study tests whether adding PCSK9 inhibitor injections (to statin treatment) can slow or improve calcific aortic valve stenosis, a condition where the heart’s aortic valve becomes stiff and narrowed. It’s aimed at adults with mild-to-moderate disease or certain people with severe disease but no symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06587971Recruiting
Intensive gum treatment for aortic stenosis
This trial tests whether intensive gum disease treatment can improve health in people with aortic stenosis (a narrowed heart valve). If you have both gum disease and mild-to-moderate aortic stenosis, you may be able to join.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06025149Recruiting
Study of a New Biological Heart Valve 'UniLine'
This study tests a new biological heart valve called 'UniLine' for people who need to replace their mitral valve (the valve between the left heart chambers) or aortic valve (the main valve sending blood to the body) for the first time. If you qualify, you would have planned surgery (not an emergency) and need to be free of certain other serious health conditions.
Kemerovo, Kemerovo OblastAges 18–80 - NCT06743568Recruiting
Comparing new valves for tight aortic valve in enlarged aorta
This trial tests two types of replacement heart valves (self-expanding and balloon-expanding) in people who have severe aortic stenosis (tight heart valve) and an enlarged aorta (the main blood vessel from the heart). The goal is to see which valve type works better for these patients.
Beijing, Beijing MunicipalityAges 65 years+ - NCT06768008Recruiting
Integrated care model for newborns with critical heart disease
This trial tests a coordinated treatment plan for newborns with critical congenital heart disease, starting before birth and continuing after delivery. It aims to improve outcomes for babies who need two-ventricle repair surgery.
BeijingAges 1 day–4 weeks - NCT07469371Recruiting
CT-FFR guided heart treatment for severe aortic stenosis
This trial tests whether using a special CT scan (CT-FFR) to guide treatment improves outcomes for people with severe aortic stenosis (a narrowed heart valve). It may help doctors decide between valve replacement surgery or a less invasive procedure.
Kunming, YunnanAges 18 years+ - NCT07107568Recruiting
Testing ways to check heart arteries before valve replacement
This trial compares different methods to evaluate coronary artery disease in patients planning to have a transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. The goal is to find out if a less invasive approach is as safe and effective as the standard one.
InnsbruckAges 18 years+ - NCT06780241Recruiting
Sex differences in valvular heart disease
This study uses special MRI scans to look at how valvular heart disease (like leaky or narrowed aortic valves) affects men and women differently. It aims to find unique biological patterns that could lead to better treatments.
Cleveland, OhioAges 18–90 - NCT06597188Enrolling by invitation
TAVR vs. Surgery for severe bicuspid aortic valve stenosis
This trial compares a less invasive valve replacement (TAVR) with traditional open-heart surgery for people with a specific type of severe aortic valve narrowing (bicuspid valve). It aims to see which approach works better for those at intermediate or low surgical risk.
Chengdu, SichuanAges 18–75 - NCT05646381RecruitingPhase 2
Drug study to slow hardening of aortic valve disease
This Phase 2 trial tests pelacarsen (TQJ230), a medication that lowers a blood fat called lipoprotein(a), to see if it slows progression of calcific aortic valve stenosis. It may help people whose valve narrowing is starting to become more severe, especially when their lipoprotein(a) level is high.
Huntsville, AlabamaAges 50–80 - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT07476703Recruiting
Extended study on the SCAPIS Stockholm reexamined group
This trial studies data and samples from people already taking part in the main SCAPIS reexamination study in Stockholm. It looks for new findings to help understand heart and lung health.
StockholmAges 56–74 - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
San Francisco, CaliforniaAges 5 months–7 months - NCT07240259Enrolling by invitation
Using a donated aortic patch to rebuild a child's windpipe
This trial tests a new way to repair a child's windpipe using a piece of donated aorta (a blood vessel) as a patch. It's for children who have severe breathing problems from a narrowed or damaged windpipe and cannot have standard surgery.
TaipeiAges birth–18 years - NCT03143361Recruiting
Aortic valve replacement registry for adults needing valve surgery
This study follows adults who are having aortic valve replacement to better understand outcomes across different hospitals in Europe. It may help your care team compare results and improve future treatment planning.
VeronaAges 18 years+ - NCT05439863Recruiting
Valve procedure trial for severe aortic valve problems
This trial studies people with severe aortic valve disease who will receive a catheter-based valve replacement (TAVR). It aims to check how well this approach works for fixing a narrowed or leaky aortic valve, and to monitor outcomes afterward.
Nanjing, JiangsuAges 18 years+ - NCT02856620Recruiting
Study heart function and frailty in people with aortic valve narrowing
This study looks at how heart mechanics, blood markers, and frailty relate to symptoms and heart measurements in people with aortic stenosis (a stiff, narrowed heart valve). It may help doctors better understand who is at higher risk and how disease changes over time.
Montreal, QuebecAges 18 years+ - NCT06713889Recruiting
Study of heart valve disease and events
This study looks for biological markers in the blood that might help predict heart-related events in people with a narrowed aortic heart valve. It aims to improve care for those with this condition, whether or not they have a procedure called TAVI to replace the valve.
LyonAges 18 years+ - NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+
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Common questions
- Are there clinical trials for aortic stenosis disease?
- Yes. Clin2 currently lists 152 recruiting aortic stenosis disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.