Clinical trials
Aortic Stenosis clinical trials
Below are recruiting aortic stenosis clinical trials, each written for real people, not researchers. We’re tracking 208 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07145463Recruiting
New delivery system for severe aortic stenosis treatment
This trial tests a new delivery system (VitaFlow Liberty Flex) for placing a replacement aortic valve in people with severe aortic stenosis. It is designed for patients whose heart anatomy (a steep angle between the heart and aorta) makes the procedure more challenging.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07276711Recruiting
Protecting brain during TAVR with EmStop device
This trial tests a new device (EmStop) that helps protect your brain during TAVR (a type of heart valve replacement). The device is placed in arteries to catch any debris that might break loose during the procedure, potentially reducing the risk of stroke.
New Orleans, LouisianaAges 22 years+ - NCT07278310Recruiting
Siegel Valve for Severe Aortic Stenosis (TAVR)
This study tests a new replacement valve called the Siegel, placed through a catheter in your leg (TAVR), for people with severe aortic stenosis. It aims to see if it is safe and effective for patients at low, intermediate, or high surgical risk.
Atlanta, GeorgiaAges 18 years+ - NCT07335900Recruiting
Studying heart healing after TAVI with FAPI-PET scan
This study uses a special type of PET scan (FAPI-PET) to see how the heart heals after a less invasive valve replacement procedure called TAVI. It aims to help doctors better understand the changes in heart tissue after treatment for aortic stenosis.
ShanghaiAges 18 years+ - NCT02448485Recruiting
Measuring Troponin T blood levels in aortic valve narrowing
This study looks at a blood test called high-sensitivity troponin T in people with aortic stenosis (a narrowed heart valve). The results may help doctors understand heart strain or risk in this condition.
Innsbruck, TyrolAges Any age - NCT07414342Recruiting
Study of RENATUS® valve for severe aortic stenosis
This study tests a new device called the RENATUS® Transcatheter Aortic Valve System for people with severe aortic stenosis. It is designed to replace the narrowed valve without open-heart surgery, and aims to see if it is safe and effective for patients with various surgical risk levels.
BeijingAges 60–100 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT07620925Recruiting
Aortic Valve Calcium Score Study Using Heart Ultrasound
This study develops and tests a new way to diagnose severe aortic stenosis (narrowing of the aortic valve) by measuring calcium buildup on the valve using heart ultrasound. If you're already getting both an ultrasound and a CT scan of your heart, this study compares how well the ultrasound method can identify severe stenosis.
BolognaAges 18 years+ - NCT06679517Enrolling by invitation
Long-term follow-up for severe aortic stenosis patients considered for TAVI
This study follows patients with severe aortic stenosis (a heart valve condition) who are being evaluated for a keyhole procedure called TAVI. It aims to understand their long-term outcomes after the standard evaluation process.
FerraraAges 18 years+ - NCT06212050Enrolling by invitation
A new valve for severe aortic stenosis in bicuspid valves
This trial tests a special heart valve (ACURATE neo2) in people with severe aortic stenosis who also have a bicuspid aortic valve, a common birth difference. The goal is to see if the valve is safe and works well for these patients.
Bad NauheimAges 18 years+ - NCT06171737Enrolling by invitation
Shared decision-making for severe aortic stenosis
This study tests a way to help people with severe aortic stenosis make informed choices about treatment. It may help you talk with your heart team about options like valve replacement.
San Francisco, CaliforniaAges 65–85 - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT04968509RecruitingPhase 3
PCSK9 shots for calcified aortic valve narrowing
This study tests whether adding PCSK9 inhibitor injections (to statin treatment) can slow or improve calcific aortic valve stenosis, a condition where the heart’s aortic valve becomes stiff and narrowed. It’s aimed at adults with mild-to-moderate disease or certain people with severe disease but no symptoms.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05133843Recruiting
Test heart blood-flow measurements before and after TAVI
This study checks whether special heart tests can better understand “in-between” blocked heart arteries before and after TAVI (a valve replacement done through a catheter). It may help doctors choose the safest, most accurate treatment when coronary artery disease is unclear.
LeipzigAges 18 years+ - NCT05646381RecruitingPhase 2
Drug study to slow hardening of aortic valve disease
This Phase 2 trial tests pelacarsen (TQJ230), a medication that lowers a blood fat called lipoprotein(a), to see if it slows progression of calcific aortic valve stenosis. It may help people whose valve narrowing is starting to become more severe, especially when their lipoprotein(a) level is high.
Huntsville, AlabamaAges 50–80 - NCT06477042Recruiting
Act on quality of life in patients with aortic stenosis
This trial studies how a TAVI procedure affects the quality of life of people with aortic stenosis, especially those with multiple health conditions. It may help doctors understand how this treatment improves daily living for patients like you.
Clermont-FerrandAges 18 years+ - NCT06587971Recruiting
Intensive gum treatment for aortic stenosis
This trial tests whether intensive gum disease treatment can improve health in people with aortic stenosis (a narrowed heart valve). If you have both gum disease and mild-to-moderate aortic stenosis, you may be able to join.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT07469371Recruiting
CT-FFR guided heart treatment for severe aortic stenosis
This trial tests whether using a special CT scan (CT-FFR) to guide treatment improves outcomes for people with severe aortic stenosis (a narrowed heart valve). It may help doctors decide between valve replacement surgery or a less invasive procedure.
Kunming, YunnanAges 18 years+ - NCT06597188Enrolling by invitation
TAVR vs. Surgery for severe bicuspid aortic valve stenosis
This trial compares a less invasive valve replacement (TAVR) with traditional open-heart surgery for people with a specific type of severe aortic valve narrowing (bicuspid valve). It aims to see which approach works better for those at intermediate or low surgical risk.
Chengdu, SichuanAges 18–75 - NCT05310461Recruiting
Early or delayed valve surgery for mixed heart valve disease
This study compares doing aortic valve replacement sooner versus waiting, in people with moderate aortic valve narrowing plus at least moderate leakage in the mitral valve. It aims to see which timing improves heart symptoms and outcomes while keeping treatment safe.
BernAges 18 years+ - NCT05739253Recruiting
Study how the aorta changes after a valve procedure
This trial looks at how the ascending aorta (the main artery near the heart) changes over time after transcatheter aortic valve replacement. It may help doctors predict who is at risk of aorta enlargement after this less-invasive valve procedure.
Beijing, Beijing MunicipalityAges Any age - NCT07267117Recruiting
Heart valve disease progression and outcomes study
This study is following people with heart valve disease (leaky or narrowed valves) to understand how the disease changes over time and what problems it may cause. It does not test a new treatment, but helps doctors learn more about valve disease progression.
Fuzhou, FujianAges 18 years+ - NCT05511792Recruiting
Smaller valve size approach versus standard valve size in TAVR
This trial compares a “smaller valve sizing” approach versus the usual sizing method during TAVR (a catheter-based valve replacement) for people with bicuspid aortic stenosis. The study aims to see which method improves safety and outcomes for the right valve fit.
Fuzhou, FujianAges 60 years+
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Common questions
- Are there clinical trials for aortic stenosis?
- Yes. Clin2 currently lists 208 recruiting aortic stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.