Clinical trials
Aortic Valve Replacement clinical trials
Below are recruiting aortic valve replacement clinical trials, each written for real people, not researchers. We’re tracking 139 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06518317RecruitingPhase 3
Short vs Long Blood Thinner Use After TAVI
This trial compares a short course versus a longer course of antiplatelet medicine (blood thinners) after a TAVI procedure for aortic stenosis. It aims to see which approach is safer and more effective.
CaenAges 18 years+ - NCT05062239Recruiting
Statin use after valve surgery to prevent heart rhythm trouble
This study looks at whether taking statin medicines around the time of surgical aortic valve replacement can lower the chance of a common post-surgery heart rhythm problem called atrial fibrillation. It also compares statin-related factors in people who are at the time of surgery in normal rhythm and not on strong rhythm-stabilizing medicines.
OdenseAges 60–95 - NCT06871774Recruiting
One vs. two closure devices for TAVR access site
This trial compares using one versus two Perclose devices to close the large hole in the leg after a TAVR procedure. It aims to find which method works better to prevent bleeding and other complications.
Milwaukee, WisconsinAges 18 years+ - NCT06800781Recruiting
Chest tube duration to prevent afib after heart surgery
This trial tests if leaving a chest tube in a little longer after heart surgery can lower the chance of developing atrial fibrillation (an irregular heart rhythm). It's for people having certain planned heart surgeries who have not had this rhythm problem before.
LundAges 18 years+ - NCT06559332Recruiting
Heart artery checks during aortic valve replacement
This study tests different ways to check for blocked heart arteries in patients getting a new aortic valve through a tube in the leg. It aims to find the best approach to guide treatment.
BernAges 70 years+ - NCT05758701RecruitingPhase 4
CT scan study for people getting TAVR
This trial studies your abdomen using a CT scan around the time you receive TAVR (a heart valve procedure). The goal is to understand how the abdomen area looks on CT and what that might mean for care.
Baltimore, MarylandAges 18–88 - NCT04139616Recruiting
Testing a planned heart rhythm plan after aortic valve replacement
This study tests an algorithm—a step-by-step plan—for how doctors manage abnormal heart rhythms after transcatheter aortic valve replacement (TAVR). It may help guide safer, more consistent care in the weeks after the procedure.
Québec, QuebecAges 18 years+ - NCT07151989Enrolling by invitation
How valve disease type affects new valve durability
This study looks at people who had their mitral valve replaced to see if the original valve problem (tight vs leaky) affects how long the new valve lasts. It may help doctors understand which patients need closer follow-up.
Maastricht, MaastrichtAges 18 years+ - NCT06535659Recruiting
VitaFlow Liberty Valve Study for Severe Aortic Stenosis
This trial tests a new valve replacement device (VitaFlow Liberty) that is inserted through a tube in an artery, avoiding open-heart surgery. It is for people with severe aortic stenosis who are at high risk for traditional surgery.
GalwayAges 18 years+ - NCT06387446Recruiting
Donated heart valve transplant for children and young adults
This study is testing a new way to replace a damaged heart valve using a donated valve (allograft) that may last longer and work better for children and young adults. It may be a good option if you need a new valve and have few other choices.
Boston, MassachusettsAges 4 weeks–50 years - NCT07001800RecruitingPhase 2/Phase 3
Slowing aortic valve disease with ataciguat
This trial tests a new pill, ataciguat, to slow down the progression of moderate calcific aortic valve stenosis (a condition where your aortic valve stiffens). If you have moderate valve narrowing and meet the other criteria, participation could help find a way to delay needing surgery.
Birmingham, AlabamaAges 50 years+ - NCT04754217Recruiting
Follow-up study after valve graft replacement
This study looks at outcomes after certain heart valve surgeries using a valved graft. It may help doctors understand how well these grafts work over time in people who have had valve replacement surgery.
Birmingham, AlabamaAges 18 years+ - NCT06069232Recruiting
Aortic valve disease risk and prognosis study
This study is looking at people with aortic valve disease to understand what factors affect their risk and to build a model that predicts how the disease will progress. Researchers hope this will help doctors better care for patients in the future.
Guangzhou, GuangdongAges 18–100 - NCT07619872Recruiting
Safety study of KONECT RESILIA heart valve replacement
This study tracks how well a new artificial aortic valve and aorta graft (called KONECT RESILIA) work after surgery in real-world patients. Researchers want to understand if it's safe and performs well over time in people who need this valve replaced.
München, BavariaAges 18 years+ - NCT07695545Recruiting
Lipid metabolism study in ascending aortic aneurysm
This study looks at how fat metabolism and cell energy centers (mitochondria) work in patients having surgery for an ascending aortic aneurysm. It aims to understand differences between people with bicuspid or tricuspid aortic valves.
DijonAges 18 years+ - NCT06414265Recruiting
Testing a new valve for severe mitral regurgitation
This trial tests a new device called the SATURN system, which places a new mitral valve without open-heart surgery. It is for people aged 65 and older with severe mitral regurgitation who are at high risk for surgery.
TbilisiAges 65 years+ - NCT05610566Recruiting
HighLife valve replacement for severe leaking mitral valve
This trial studies a new catheter-based valve replacement system for people with moderate to severe, or severe, mitral valve regurgitation (a leaky mitral valve). It aims to check whether the procedure is safe and can improve heart function compared with expected care.
Suzhou, JiangsuAges 18 years+ - NCT07042529Recruiting
Optimizing valve placement during TAVI
This trial is testing a better way to position a new heart valve during a TAVI procedure. The goal is to help the valve work as well as possible for people with severe aortic stenosis.
AalstAges 18 years+ - NCT07099859RecruitingPhase 4
Losartan after aortic valve surgery for severe leakage
This trial tests if the drug losartan can help the heart recover better after surgery to replace a leaky aortic valve. It may reduce strain on the heart and improve long-term outcomes.
São Paulo, São PauloAges 18–85 - NCT06898086Enrolling by invitation
TAVI with or without heart artery check for severe aortic stenosis
This trial compares two approaches for replacing a tight aortic heart valve (TAVI) through a leg artery: doing it with or without a routine check of your heart's arteries (coronary angiogram). If you have severe aortic stenosis and are scheduled for TAVI, this study helps find out whether skipping the artery check is safe and effective.
GrazAges 18 years+ - NCT06552689Recruiting
Testing Sutra Hemi-valve for leaky mitral valve
This trial tests a new, less invasive heart valve (Sutra Hemi-valve) for people with a leaky mitral valve who cannot have standard surgery. The valve is delivered through a vein in your leg, so you avoid open-heart surgery.
HamiltonAges 18 years+ - NCT03470246Recruiting
Wearable activity coaching after heart surgery
This study tests a personalized activity program and coaching after heart surgery, using wearable sensors to track movement. It may help you recover more safely and move in a goal-directed way during rehabilitation.
KuopioAges 30–90 - NCT04636684Recruiting
Study ATTR deposits in the aortic valve
This study looks at how common ATTR-related protein deposits are in the heart valve of people with age-related (degenerative) aortic stenosis. It may help doctors understand how important these deposits are and could guide future treatment decisions.
ToulouseAges 18–99 - NCT07691307Recruiting
TruGamma tricuspid valve replacement study
This trial tests a new device called TruGamma to replace the tricuspid valve without open-heart surgery. It is for older adults with severe tricuspid regurgitation who cannot have surgery and still have symptoms despite medication.
Beijing, Beijing MunicipalityAges 65 years+
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Common questions
- Are there clinical trials for aortic valve replacement?
- Yes. Clin2 currently lists 139 recruiting aortic valve replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.