Clinical trials
Aortic Valve Stenosis clinical trials
Below are recruiting aortic valve stenosis clinical trials, each written for real people, not researchers. We’re tracking 205 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06049654Recruiting
Comparing Allegra and Sapien valves for valve-in-valve procedure
This trial tests two different replacement heart valves (Allegra and Sapien) to see which works better for people who need a new valve placed inside a previously implanted surgical valve. It aims to help patients with a failing biological aortic valve who are already scheduled for this procedure.
AlessandriaAges 18 years+ - NCT06008080Recruiting
Study following patients after Navitor valve implant
This study is checking how well the Navitor heart valve works in real-world patients. If you are scheduled to get this valve, you may be able to join.
AdelaideAges 18–100 - NCT06000943Recruiting
Bleeding and clot risk after heart valve procedure
This study looks at patients who had a TAVR procedure (a new valve put in the heart) to understand their risk of bleeding or clots over the next year. It tracks changes in blood thinner medications at 1 month, 90 days, and 1 year to help doctors personalize care.
AalstAges 18 years+ - NCT05932615Enrolling by invitation
Testing a new transcatheter valve for aortic valve narrowing
This trial studies how safe and effective the NAVITOR valve is for treating narrowed aortic valves placed through a catheter (no open-heart surgery). It may be an option if you’re at intermediate-to-low surgical risk and meet heart ultrasound/CT measurements.
Birmingham, AlabamaAges 18 years+ - NCT05909748Recruiting
First-in-human test of a new TAVR valve for severe aortic narrowing
This trial tests a new heart valve replacement (TAVR) system in people with severe, symptomatic aortic stenosis. If you qualify, it may offer a less invasive option compared with open-heart valve surgery, while also helping researchers understand safety and early effectiveness.
Petah TikvaAges 18–120 - NCT05851209Recruiting
Study biomarkers in people with moderate aortic valve narrowing
This study looks at blood and/or body signals (called biomarkers) to understand why aortic valve narrowing may worsen and what outcomes people have. You may be able to help researchers by undergoing regular heart care plus additional testing like MRI or CT if you qualify.
BonnAges 18 years+ - NCT05779787Recruiting
Registry after aortic valve procedure to guide future care
This registry is for people with severe, symptomatic aortic valve narrowing who are planning a TAVI procedure (a less invasive valve replacement). It aims to better track and improve how patients do after the valve is replaced, based on how the procedure is planned and performed.
Milan, LombardyAges 18 years+ - NCT05758662Recruiting
PET-CT and heart ultrasound study valve changes after TAVI
This study looks at whether certain valve blood clots (called “subclinical leaflet thrombosis”) and different valve types are linked to valve aging over time. It uses a special PET-CT scan and an echocardiogram to measure changes in the heart valve about five years after TAVI.
CopenhagenAges 18 years+ - NCT05711186Recruiting
Shared decision support for aortic valve procedures
This trial tests a structured, team-guided conversation to help you choose between two common valve procedures: SAVR (surgery) or TAVR (a less invasive procedure done through the groin). It may help you make a choice that fits your health goals and preferences.
BernAges 70 years+ - NCT05714293Enrolling by invitation
CT measurements after surgical aortic valve replacement
This study uses a CT scan (with contrast dye) to measure the coronary artery openings after people have a new aortic valve placed surgically. It aims to see how to best plan or understand coronary blood flow after the surgery.
RomaAges 18–80 - NCT05646381RecruitingPhase 2
Drug study to slow hardening of aortic valve disease
This Phase 2 trial tests pelacarsen (TQJ230), a medication that lowers a blood fat called lipoprotein(a), to see if it slows progression of calcific aortic valve stenosis. It may help people whose valve narrowing is starting to become more severe, especially when their lipoprotein(a) level is high.
Huntsville, AlabamaAges 50–80 - NCT05672836RecruitingPhase 4
Enavogliflozin after TAVR for heart narrowing with mild heart weakness
This trial tests enavogliflozin (a diabetes medication that may help the heart) in people who have had a TAVR procedure for severe aortic stenosis. It looks at whether the medicine can improve outcomes for people with symptoms and mildly reduced or preserved pumping function.
Bucheon-siAges 19 years+ - NCT05603026Recruiting
MRI study for people getting a valve replacement
This study uses MRI (a type of scan) in people who are scheduled for a catheter-based aortic valve replacement through the groin. It aims to see how well MRI can work for these patients and potentially improve care planning around the procedure.
Cleveland, OhioAges 18–105 - NCT04889872Recruiting
Watchful waiting or TAVR for moderate aortic valve narrowing
This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
Huntsville, AlabamaAges 65 years+ - NCT05459233Recruiting
Testing ultrasound-guided valve settings after valve-in-valve TAVR
This trial compares two ways to check and fine-tune how well a new valve is working after a “valve-in-valve” TAVR procedure. It looks to see whether measurements from ultrasound of the heart (Doppler echocardiography) match results from a catheter test, which could help guide safer, more accurate valve care.
San Francisco, CaliforniaAges 18 years+ - NCT05283356RecruitingPhase 4
Ticagrelor or aspirin after heart valve replacement
This trial compares two blood thinners (ticagrelor and aspirin) to see which one works better at preventing blood clots after a less-invasive heart valve replacement (TAVI). It is for people with severe aortic stenosis who also have diabetes, heart disease, or artery disease.
Vigo, PontevedraAges 18 years+ - NCT05172973Recruiting
New valve procedure for failing aortic bioprosthetic valves
This trial studies whether a new transcatheter aortic valve (SAPIEN X4) is safe and works well in people whose previously implanted aortic valve is now failing. It may help reduce valve symptoms in higher-surgery-risk patients who are not good candidates for open-heart valve replacement.
Newport Beach, CaliforniaAges Any age - NCT04126018Recruiting
MRI scan comparison for certain leaking or narrowed heart valves
This trial studies how well different MRI images can assess heart valve problems—like leaking (regurgitation) or narrowing (stenosis). It may help doctors get clearer information, especially in people who may not respond well to cardiac resynchronization therapy (CRT).
Cleveland, OhioAges 18–90 - NCT04275726Recruiting
Myval heart valve study for adults needing TAVI
This trial studies whether the Myval THV (a new heart valve) is safe and effective for adults who need TAVI, a procedure to replace a narrowed heart valve without open-heart surgery. You may be considered if a heart team says you’re a good candidate for this valve procedure and you’re willing to join the study.
MinskAges 18 years+ - NCT04204915Recruiting
Early valve replacement for severe but symptom-free aortic narrowing
This study looks at whether replacing a narrowed heart valve early helps people who have severe aortic stenosis but no symptoms. You would be randomly assigned to early valve replacement or careful waiting with regular check-ups.
Garran, Australian Capital TerritoryAges 18 years+ - NCT03728049Recruiting
Blood test during TAVI to improve heart valve procedure outcomes
This study checks whether a quick bedside blood test helps guide care during a minimally invasive TAVI procedure (a new valve put in without open-heart surgery). It may improve safety and outcomes by helping the team manage bleeding-related decisions in real time.
Clermont-FerrandAges 18 years+ - NCT06477042Recruiting
Act on quality of life in patients with aortic stenosis
This trial studies how a TAVI procedure affects the quality of life of people with aortic stenosis, especially those with multiple health conditions. It may help doctors understand how this treatment improves daily living for patients like you.
Clermont-FerrandAges 18 years+ - NCT07469371Recruiting
CT-FFR guided heart treatment for severe aortic stenosis
This trial tests whether using a special CT scan (CT-FFR) to guide treatment improves outcomes for people with severe aortic stenosis (a narrowed heart valve). It may help doctors decide between valve replacement surgery or a less invasive procedure.
Kunming, YunnanAges 18 years+ - NCT07359898Recruiting
Study of a new heart valve for aortic stenosis
This study is testing a new type of heart valve (Navitor or Navitor Vision) for people with aortic stenosis. The valve is placed without open-heart surgery, and the goal is to see how well it works in a real-world setting. If you've already been recommended for this procedure by your heart team, you may be able to join.
San Donato Milanese, LombardyAges 18 years+
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Common questions
- Are there clinical trials for aortic valve stenosis?
- Yes. Clin2 currently lists 205 recruiting aortic valve stenosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a aortic valve stenosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a aortic valve stenosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.