Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06923995Recruiting
AI-based depression and anxiety assessment study
This study tests an AI tool that analyzes video and audio recordings to measure depression and anxiety. It is for people starting a new treatment for depression or anxiety and aims to see if the AI can accurately track their progress.
Houston, TexasAges 18–65 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT03953014Recruiting
Genetic study of antidepressant side effects in young people
This trial studies whether genes (using a saliva sample) can help explain why some young people feel more “disinhibited” after taking antidepressants like SSRIs. If you’ve had depression, anxiety, or OCD and have used an SSRI, your information and genetics may help improve how antidepressants are chosen and monitored.
Calgary, AlbertaAges 6–17 - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT07174947RecruitingPhase 2
Fluoxetine plus immunotherapy for advanced liver cancer with depression
This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help treat advanced liver or bile duct cancer in people who also have depression or anxiety. You must not have received any prior cancer treatment and be ready to start immunotherapy as your first therapy.
Wenzhou, ZhejiangAges 18–80 - NCT07174557Recruiting
Remote monitoring to prevent depression relapse
This study tests whether remote check-ins via smartphone can help people who have recovered from depression stay well after leaving a collaborative care program. If you've recently finished depression treatment and feel better, you may be eligible.
Hanover, New HampshireAges 18 years+ - NCT07490782Recruiting
Nutrition study for college students with depression
This trial tests whether changes in diet can help improve mild to moderate depression in college students. If you are currently getting treatment or are open to it, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT06594588Recruiting
Aerobic exercise for depression in adults
This trial tests whether adding a personalized aerobic exercise program to your usual depression treatment can help you feel better. It is for adults aged 18-45 with depression who are not currently in regular psychotherapy.
Beijing, Beijing MunicipalityAges 18–45 - NCT06835855Recruiting
Does mother’s depression affect baby’s attention to emotions?
This study looks at how babies of mothers with depression pay attention to emotional faces. Researchers want to learn if these babies show different patterns of attention to happy or sad cues, which could help understand early development.
Binghamton, New YorkAges 6 months+ - NCT07143838Recruiting
Enhancing deep sleep to help depression
This study tests a gentle brain stimulation method (called transcranial electrical stimulation) during sleep to see if it can improve deep sleep and help with depression symptoms. It is for adults with moderate depression who also have some memory or thinking complaints.
Winston-Salem, North CarolinaAges 40–80 - NCT07188623Recruiting
Virtual reality therapy for older adults with depression
This study tests if a virtual reality program can help older adults with depression become more active and feel better. You would use a VR headset at home to practice activities that improve your mood.
Stanford, CaliforniaAges 65 years+ - NCT05680220Recruiting
40 Hz light therapy for adults with depression
This trial studies whether daily 40 Hz light stimulation can reduce symptoms of major depression. You’d use a light device for about an hour each day for 6 weeks, while researchers track changes in depression severity.
Copenhagen, DenmarkAges 18–75 - NCT06616116Recruiting
Stress Management with Real-Time Body Signal Feedback
This trial tests a stress management program that uses real-time feedback from your body signals (like heart rate). It is for people with mood disorders, such as depression or bipolar disorder, who also feel anxious or stressed. The goal is to help you learn to control your stress better.
Seoul, Jongno-guAges 15–59 - NCT06480201RecruitingPhase 1
Ketamine for treatment-resistant depression: a brain wave study
This study tests whether a single dose of ketamine can change brain wave patterns (called gamma oscillations) in people with treatment-resistant depression. Researchers want to see if these brain waves can predict who will feel better after treatment.
Houston, TexasAges 21–45 - NCT07611773Recruiting
Brain Stimulation for Depression Treatment Planning
This study tests whether brain scans can predict which people with depression will benefit from transcranial direct current stimulation (tDCS)—a non-invasive treatment that uses mild electrical pulses to stimulate brain areas related to mood. You would use a small home device and complete brain monitoring sessions.
ValenciaAges 18 years+ - NCT06773949Recruiting
Exercise before rTMS for hard-to-treat depression
This trial tests if doing exercise before repetitive transcranial magnetic stimulation (rTMS) can improve depression symptoms in people who haven't gotten better with standard treatments.
Ottawa, OntarioAges 18–75 - NCT07603804Recruiting
Accelerated Brain Stimulation for Treatment-Resistant Depression
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
IstanbulAges 18–65 - NCT06045897Recruiting
EEG brain test for young people at risk of psychosis
This study uses a short EEG recording to look at brain activity patterns in young people with early signs of mental health conditions, including those at risk for psychosis, first episode psychosis, depression, or autism. It aims to find brain markers that could help identify people who might benefit from early treatment.
ParisAges 15–30 - NCT07180342Recruiting
Nature outings for depression recovery
This study tests whether nature-based group trips can help people with major depression feel better. You would visit parks and do outdoor activities while researchers measure changes in mood and daily function.
Jinan, ShandongAges 18–59 - NCT07140913RecruitingPhase 3
Testing KarXT for bipolar I mania with mood stabilizers
This study tests whether adding KarXT to lithium, valproate, or lamotrigine helps calm manic episodes in people with bipolar I disorder. It aims to see if the combination is safe and works better than the mood stabilizer alone.
Bentonville, ArkansasAges 18–65 - NCT06668571RecruitingPhase 2
Ketamine for treatment-resistant depression
This study tests if intravenous ketamine can help people with treatment-resistant depression who haven't found relief from at least two other treatments. If you qualify, you'll receive ketamine infusions to see if it improves your mood.
Rochester, MinnesotaAges 18–65
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 408 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.