Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 404 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04999553Recruiting
Comparing brain stimulation on left vs right side for depression
This study tests whether delivering a type of brain stimulation to the left side of the head is as effective as delivering it to the right side for treating major depression. The treatment is called transcranial magnetic stimulation (TMS), which uses magnetic pulses to stimulate brain areas involved in mood.
Vancouver, British ColumbiaAges 18–65 - NCT06911931Recruiting
Visual perception study in schizophrenia and bipolar disorder
This study looks at how people with schizophrenia or bipolar disorder see the world. By comparing their visual perception to people without these conditions, researchers hope to learn more about how the brain processes what we see.
Rochester, New YorkAges 18–65 - NCT07682207Recruiting
Accelerated brain stimulation for PTSD and depression
This study tests an accelerated form of brain stimulation called iTBS to see if it can help people with both PTSD and depression. It may be a good option if you have not found enough relief from your current treatments.
London, OntarioAges 18 years+ - NCT06630065Recruiting
Ketamine study for depression using brain scans
This trial uses brain scans to understand how ketamine affects negative emotions in people with depression. It may help explain why ketamine works and who benefits most.
Paris, ParisAges 18 years+ - NCT06914284Recruiting
Apathy and thinking changes in older adults with bipolar disorder
This study looks at whether apathy and certain brain markers can help predict memory and thinking problems in people over 70 with bipolar disorder. If you are 70-85, have bipolar disorder, and are currently stable (no recent mood episodes), you may be able to join.
Rennes, Ile Et VilaineAges 70–85 - NCT06923995Recruiting
AI-based depression and anxiety assessment study
This study tests an AI tool that analyzes video and audio recordings to measure depression and anxiety. It is for people starting a new treatment for depression or anxiety and aims to see if the AI can accurately track their progress.
Houston, TexasAges 18–65 - NCT06163625Recruiting
Brain activity and memory in treatment-resistant depression
This study looks at how the brain's frontal lobe (DLPFC) works during memory tasks in people with treatment-resistant depression. It compares brain activity between depressed patients and healthy controls using MRI and possibly a brain stimulation technique (rTMS). It aims to understand why some people don't respond to standard treatments.
Toronto, OntarioAges 18–65 - NCT05892744RecruitingPhase 4
Testing brain scans to help choose depression treatment
This trial studies how brain signals measured by MRI and EEG may help doctors choose the best treatment for depression. It focuses on people with early-onset, long-lasting or recurring major depression, and tests whether these “brain biomarkers” track with treatment choice and response.
Austin, TexasAges 18–65 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT03953014Recruiting
Genetic study of antidepressant side effects in young people
This trial studies whether genes (using a saliva sample) can help explain why some young people feel more “disinhibited” after taking antidepressants like SSRIs. If you’ve had depression, anxiety, or OCD and have used an SSRI, your information and genetics may help improve how antidepressants are chosen and monitored.
Calgary, AlbertaAges 6–17 - NCT06005194Recruiting
Exercise therapy via telehealth for depression after brain injury
This study tests whether an exercise program delivered through video calls can help treat major depression in people who have had a traumatic brain injury. If you are at least one year past your injury and have symptoms of depression, you may be able to join.
Seattle, WashingtonAges 18–64 - NCT07657234RecruitingPhase 1/Phase 2
Brain stimulation for depression in older adults
This study tests whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can help treat depression in people aged 60 and older. tDCS uses a mild electrical current to gently stimulate the brain and may improve mood when added to your current depression treatment.
Dallas, TexasAges 60 years+ - NCT07174947RecruitingPhase 2
Fluoxetine plus immunotherapy for advanced liver cancer with depression
This study tests whether adding the antidepressant fluoxetine (Prozac) to standard immunotherapy can help treat advanced liver or bile duct cancer in people who also have depression or anxiety. You must not have received any prior cancer treatment and be ready to start immunotherapy as your first therapy.
Wenzhou, ZhejiangAges 18–80 - NCT05051618Recruiting
Exercise program for depression in people with multiple sclerosis
This trial studies whether a structured exercise program can help reduce symptoms of major depressive disorder in people who also have multiple sclerosis. You’ll complete questionnaires, wear an activity sensor, and do exercise testing while being assigned to the study program.
Chicago, IllinoisAges 18–64 - NCT07210112RecruitingPhase 2
Psilocybin and Trazodone for tough-to-treat depression
This trial tests if taking psilocybin (a psychedelic drug) with trazodone (an antidepressant) can help people whose depression hasn't improved with at least two standard antidepressants. If you have treatment-resistant depression, this study might be an option.
ParisAges 18 years+ - NCT07680140RecruitingPhase 4
Using biomarkers to choose depression treatment
This study uses a blood test (biomarker) to help pick the antidepressant that might work best for you. It compares two treatments—standard antidepressants and ketamine—in people with major depression who haven't gotten enough relief from one prior treatment.
New York, New YorkAges 18–70 - NCT07611773Recruiting
Brain Stimulation for Depression Treatment Planning
This study tests whether brain scans can predict which people with depression will benefit from transcranial direct current stimulation (tDCS)—a non-invasive treatment that uses mild electrical pulses to stimulate brain areas related to mood. You would use a small home device and complete brain monitoring sessions.
ValenciaAges 18 years+ - NCT07603804Recruiting
Accelerated Brain Stimulation for Treatment-Resistant Depression
This study tests an accelerated form of iTBS (a non-invasive brain stimulation technique) for depression that hasn't improved with antidepressant medications. The goal is to help people with major depression who haven't responded adequately to at least one antidepressant drug.
IstanbulAges 18–65 - NCT07490782Recruiting
Nutrition study for college students with depression
This trial tests whether changes in diet can help improve mild to moderate depression in college students. If you are currently getting treatment or are open to it, you may be able to join.
La Jolla, CaliforniaAges 18 years+ - NCT07188623Recruiting
Virtual reality therapy for older adults with depression
This study tests if a virtual reality program can help older adults with depression become more active and feel better. You would use a VR headset at home to practice activities that improve your mood.
Stanford, CaliforniaAges 65 years+ - NCT07174557Recruiting
Remote monitoring to prevent depression relapse
This study tests whether remote check-ins via smartphone can help people who have recovered from depression stay well after leaving a collaborative care program. If you've recently finished depression treatment and feel better, you may be eligible.
Hanover, New HampshireAges 18 years+ - NCT07143838Recruiting
Enhancing deep sleep to help depression
This study tests a gentle brain stimulation method (called transcranial electrical stimulation) during sleep to see if it can improve deep sleep and help with depression symptoms. It is for adults with moderate depression who also have some memory or thinking complaints.
Winston-Salem, North CarolinaAges 40–80 - NCT06594588Recruiting
Aerobic exercise for depression in adults
This trial tests whether adding a personalized aerobic exercise program to your usual depression treatment can help you feel better. It is for adults aged 18-45 with depression who are not currently in regular psychotherapy.
Beijing, Beijing MunicipalityAges 18–45 - NCT06835855Recruiting
Does mother’s depression affect baby’s attention to emotions?
This study looks at how babies of mothers with depression pay attention to emotional faces. Researchers want to learn if these babies show different patterns of attention to happy or sad cues, which could help understand early development.
Binghamton, New YorkAges 6 months+
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 404 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.