Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 404 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06929273RecruitingPhase 3
Long-term safety study of KarXT for bipolar I mania
This study tests the long-term safety of KarXT for people with bipolar I disorder who are having a manic or mixed episode. It is for people who either completed a previous KarXT study or are new to the study and have moderate to severe mania symptoms.
Glendale, ArizonaAges 18–65 - NCT03522545RecruitingPhase 1
Stem cell add-on for hard-to-treat bipolar depression
This Phase 1 study tests whether adding allogeneic (donor) stem cells to standard care is safe and may help adults with bipolar depression that has not improved with usual treatments. It mainly targets people with more severe symptoms and certain blood inflammation levels.
Houston, TexasAges 18–65 - NCT03859297Recruiting
Testing how rumination changes in depressed teens
This study looks at what changes in “rumination” (repetitive worrying/thinking about negative thoughts) in teens with depression, and how those changes relate to recovery. It’s for ages 14–17 who have had major depression and meet specific screening and medical rules.
Columbus, OhioAges 14–17 - NCT06555406Recruiting
Healthy lifestyle study for bipolar disorder with sleep issues
This study tests a healthy lifestyle program for people with bipolar disorder who have sleep or schedule problems. It aims to see if changing daily habits can help improve mood and sleep.
Berkeley, CaliforniaAges 18–65 - NCT06523439Recruiting
Brain stimulation for depression in young people
This study tests a new type of brain stimulation called accelerated intermittent theta burst stimulation (aiTBS) in young people (ages 13-20) with depression who have not tried many treatments before. The goal is to see if this treatment can safely help reduce depression symptoms.
Austin, TexasAges 13–20 - NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Dothan, AlabamaAges 10–17 - NCT04191811Recruiting
Using brain signals to predict CBT success for mood or sleep issues
This study tests whether brain measurements can help predict who will benefit from a type of talk therapy called CBT (cognitive behavioral therapy). If you have depression, social anxiety, or insomnia, your brain “response variability” may be used to personalize or improve treatment planning.
Huddinge, Stockholm CountyAges 18 years+ - NCT02604277Recruiting
Study of suicidal behavior in people with bipolar disorder
This study looks at suicidal thoughts or behaviors in people diagnosed with bipolar disorder. It may help researchers understand what leads to suicidal risk and how to better support safety and treatment.
Atlanta, GeorgiaAges 18–64 - NCT04870255Recruiting
Brain stimulation for depression in borderline personality disorder
This study tests a type of brain stimulation called rTMS to see if it can help improve mood in people who have both depression and borderline personality disorder. It may offer a new treatment option for those who haven't tried TMS before.
Stanford, CaliforniaAges 18–80 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65 - NCT07758010Recruiting
Brain stimulation for treatment-resistant depression
This study tests a type of brain stimulation called cTBS (continuous theta burst stimulation) applied to a specific part of the brain (the precuneus) to see if it helps with treatment-resistant depression. It aims to provide a new option for people who haven't found relief from standard treatments.
Belmont, MassachusettsAges 18 years+ - NCT07359157Recruiting
Support program for WRCH patients with legal history
This study offers a group program at Worcester Recovery Center and Hospital (WRCH) aimed at helping people who have been involved with the legal system. It is designed for current patients at WRCH who are at least 18 years old and comfortable speaking English.
Worcester, MassachusettsAges 18 years+ - NCT07476469Recruiting
Nerve stimulation for anhedonia and anxiety
This study tests whether a gentle nerve stimulation device (tVNS) placed on your ear can help reduce symptoms of anhedonia (loss of pleasure) and anxiety. You will also have brain scans (MRI) to see how the treatment affects your brain.
BonnAges 18–40 - NCT07638553RecruitingPhase 3
Psilocybin to prevent alcohol relapse with depression
This study tests whether psilocybin (a psychedelic compound) can help people with severe alcohol use disorder stay sober longer, especially if they also have depression. Participants receive guided psilocybin sessions alongside counseling to reduce the risk of returning to heavy drinking.
BayonneAges 18 years+ - NCT06746155Recruiting
Predictors of relapse in major depression
This study looks at adults with major depressive disorder who have responded to treatment, to find out what might predict a relapse. You will wear a wrist activity monitor and complete questionnaires.
Calgary, AlbertaAges 18–70 - NCT06763081Recruiting
SSRI side effects genetics study
This study looks at why some people have behavioral side effects when taking SSRI antidepressants like Prozac or Zoloft. It hopes to find a genetic reason to help doctors choose safer treatments in the future.
Winnipeg, ManitobaAges 6–24 - NCT07637799Recruiting
Parent support group for teens with autism and anxiety or depression
This study tests whether a parent support group helps families manage anxiety or depression in teenagers who have autism. The group teaches parents skills to support their teen at home.
GothenburgAges 12 years+ - NCT07478796RecruitingPhase 4
Blood-based dosing of SSRIs for hospitalized depression
This study tests whether adjusting the dose of common antidepressants (SSRIs) based on regular blood tests can help people in the hospital feel better faster. It is for adults and teens age 12 and older with moderate to severe depression who are starting fluoxetine, escitalopram, or sertraline.
Poznan, Greater Poland VoivodeshipAges 12 years+ - NCT06758414Recruiting
CBT for chronic pain in veterans with serious mental illness
This trial tests a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain, designed for veterans with serious mental illness. It aims to help you manage back pain and improve your quality of life.
Baltimore, MarylandAges 18 years+ - NCT05989451Recruiting
Talk therapy for depression and anxiety
This trial tests a type of talk therapy called dialectical behavior therapy (DBT) adapted to help people with emotional disorders like depression or anxiety. It aims to improve emotional regulation and reduce symptoms.
TaipeiAges 18–65 - NCT07337889Recruiting
Borderline personality as a relationship disorder study
This study compares people with borderline personality disorder, bipolar disorder, and healthy controls to understand how relationships are affected. It may help find better ways to support people with these conditions.
MontpellierAges 18–45 - NCT01980147Recruiting
Skills for Wellness program for youth coping with mental health risks
This trial tests a structured skills program to help children and teens (ages 9–21) cope with early mental health warning signs such as anxiety, mood swings, or unusual thoughts. It may help participants build practical coping tools and well-being.
Halifax, Nova ScotiaAges 9–21 - NCT06528938Recruiting
Accelerated vs. standard TMS for teen depression
This study tests whether a faster, brain-guided form of TMS (called iTBS) can help treat depression in teenagers better than standard TMS. You may qualify if you're 16–19, have tried an antidepressant that didn't work well, and have no medical reasons to avoid TMS or MRI.
Ottawa, OntarioAges 16–19 - NCT05703412Enrolling by invitation
Text or app check-ins after discharge for serious mental illness
This study tests an mHealth (phone-based) program that helps people with serious mental illness after leaving the hospital. It may help you stay connected to care and support in the community after discharge.
Providence, Rhode IslandAges 18 years+
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 404 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.