Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 408 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06919133Enrolling by invitation
Using smartphone markers to manage depression symptoms
This study tests whether using a smartphone app to track your mood and behavior can help you manage depression symptoms better. You'll use digital tools to monitor your own progress and learn self-management strategies.
FrederiksbergAges 18 years+ - NCT07226011Recruiting
Fast High-Dose Brain Stimulation for Depression
This study tests a stronger, faster type of brain stimulation (called tDCS) to see if it can help treat depression. It may be a good fit if you have major depression and haven't used other brain stimulation in the past 6 months.
Charleston, South CarolinaAges 18–70 - NCT07696871RecruitingPhase 1/Phase 2
Cannabidiol oil for treatment-resistant depression
This trial tests if cannabidiol (CBD) oil can help people with major depression that has not improved with standard antidepressants. You will take CBD oil or a placebo while continuing your current antidepressant treatment to see if it improves your symptoms.
Tubarão, Santa CatarinaAges 18–69 - NCT06972368Recruiting
Home brain stimulation for depression in borderline personality disorder
This trial tests whether a gentle brain stimulation device (tDCS) used at home can help with depression in people with borderline personality disorder. If you have BPD and current depression, you may be able to participate from home using your smartphone.
Montreal, QuebecAges 18–65 - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
Stanford, CaliforniaAges 22–65 - NCT07398040Enrolling by invitation
Anti-inflammatory diet for anxiety and depression
This study tests whether following a personalized anti-inflammatory diet can help reduce symptoms of anxiety, depression, or stress. You would need to live in Zaragoza, speak Spanish, and already have a low-to-moderate Mediterranean diet score.
Zaragoza, ZaragozaAges 18 years+ - NCT06454695Recruiting
Treating depression by reducing negative future images
This study tests a new way to treat major depression by helping people change distressing mental pictures they have about the future. It might be a good fit if you have a few specific negative images that bother you.
Amsterdam, North HollandAges 18 years+ - NCT06780917Recruiting
Online cognitive testing for older adults with depression or memory concerns
This study tests whether an online cognitive assessment platform (Creyos) is valid for older adults with major depression or mild cognitive impairment. Participants will complete brain games or puzzles to see how well the online tool measures thinking skills.
Toronto, OntarioAges 60 years+ - NCT06633263Enrolling by invitation
Combined therapy for depression and insomnia
This trial tests a combination of two behavioral therapies to improve both depression symptoms and sleep problems. It may help you if you have moderate depression and insomnia and can participate in French-language sessions.
LiègeAges 18–67 - NCT05569018Recruiting
Spanish blended group therapy for anxiety and depression symptoms
This study tests whether a group therapy program delivered in both online and in-person formats can reduce emotional symptoms like anxiety and depression. If you qualify, you may be assigned to receive this structured group treatment during the study period.
Castellon, CastellónAges 18 years+ - NCT07500714Recruiting
Digital therapy for depression using AI
This study uses a smartphone app and artificial intelligence to deliver a special type of talk therapy for people with moderate to severe depression. It aims to provide personalized care without needing to change your current treatment.
Taichung, TaichungAges 18–75 - NCT06542094Recruiting
Brain stimulation for severe depression that hasn't improved with other treatments
This trial tests if deep brain stimulation (a device that sends tiny electrical pulses to mood-related brain areas) can help people with tough-to-treat depression. It uses brain-signal monitoring to see which patterns predict improvement.
Chengdu, SichuanAges 18–65 - NCT05553353Recruiting
Repeated brain stimulation for depression after spinal cord injury
This study tests a non-drug treatment called repeated transcranial magnetic stimulation (rTMS) to reduce depression symptoms in people with depression after a spinal cord injury. You might be eligible if you have ongoing major depression and can safely receive magnetic pulses to the head.
Charleston, South CarolinaAges 18–60 - NCT06086366Recruiting
Brain scan study for depression after COVID-19
This study uses brain scans to understand depression that starts soon after COVID-19. Researchers want to see if there are changes in brain chemistry related to depression, and you may help find new treatment targets.
Toronto, OntarioAges 18–75 - NCT07007247Enrolling by invitation
Digital aftercare for teens with depression after hospital discharge
This pilot study tests a digital program to support adolescents aged 12–17 with depression after they leave the hospital. It aims to help prevent relapse and improve well-being using a smartphone, tablet, or computer.
HamburgAges 12–17 - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT06671977RecruitingPhase 1
Safety and effects of DMT in healthy adults and those with depression
This trial studies the safety and effects of DMT, a psychedelic compound, in healthy volunteers and people with major depressive disorder (MDD) who haven't responded well to antidepressants. It aims to see how DMT affects the brain and mood.
West Haven, ConnecticutAges 21–65 - NCT07018245RecruitingPhase 2
TJ0113 Capsule for depression: a phase 2 study
This trial tests an investigational medication called TJ0113 for people with moderate to severe depression. It aims to see if the drug can safely improve depression symptoms when other treatments are stopped during the study.
Hangzhou, ZhejiangAges 18–65 - NCT05570812RecruitingPhase 2
Pregnenolone to improve depressed mood in people with HIV
This Phase 2 trial tests a brain-acting steroid called pregnenolone to help reduce depressed mood. It studies whether it can improve mood in adults with HIV who are already on HIV treatment and still have depression symptoms.
Boston, MassachusettsAges 18–85 - NCT06928480Recruiting
Unified Protocol for Emotional Health in Long COVID
This study tests a program to help people with Long COVID manage emotional difficulties like depression or anxiety. It combines different therapy approaches into one treatment, which you can receive online from home.
Zaragoza, ZaragozaAges 18 years+ - NCT06820723RecruitingPhase 2
Testing a single dose of CYB003 for depression and anxiety
This trial tests a single dose of an investigational drug (CYB003) in people with depression and anxiety who haven't gotten enough help from their current antidepressant. You would take a psilocybin-like medication and be monitored for how it affects your mood and anxiety.
Columbus, OhioAges 21–65 - NCT04996433Recruiting
Compare two talk therapy programs for treatment-resistant depression
This study compares two psychotherapy programs to help people who have ongoing, difficult-to-treat depression while in inpatient care. If you qualify, you’ll receive one of the therapy programs and be followed to see which approach helps depression symptoms more.
Berlin, State of BerlinAges 18–75 - NCT06442423RecruitingPhase 1
Psilocybin study for people with psychiatric symptoms
This trial tests if psilocybin, a substance found in certain mushrooms, can help people with various mental health symptoms that affect daily life. You would take a single dose in a supervised setting and be monitored for changes in your mood and well-being.
New Haven, ConnecticutAges 18 years+ - NCT06740396Recruiting
Depression in heart disease patients in Baghdad
This study looks at how common depression is in people with coronary artery disease and how severe it is. If you have heart disease and are being treated at a hospital in Baghdad, you can help doctors understand the link between heart health and mental health.
BaghdadAges 18 years+
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 408 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.