Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05295888Recruiting
Temporal Interference treatment for moderate-to-severe depression
This study tests temporal interference (TI), a brain stimulation method, to treat depression. You may be a candidate if you have moderate-to-severe major depression and can follow the study schedule and safety screening.
Toronto, OntarioAges 18–65 - NCT05450432RecruitingPhase 4
Ketamine maintenance to help prevent suicidal thoughts
This Phase 4 study tests whether ongoing treatment with ketamine or esketamine can reduce suicidal thoughts in people with major depression who are at high risk. Because the study focuses on long-term maintenance, you’d receive treatment over time while being closely monitored for safety and mental health changes.
Boston, MassachusettsAges 18–70 - NCT05523817Recruiting
Brain scan targeting to improve specific depression symptoms
This study uses brain-signal targeting (likely with MRI) to see whether it can improve certain symptoms of depression. You may be able to join if you’re 18–65 and currently have a depressive episode, and if you can safely complete the scan.
Boston, MassachusettsAges 18–65 - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06234176Recruiting
Psychomotor therapy for quality of life in depression
This study tests whether a special type of therapy called psychomotor therapy (which focuses on the connection between your mind and body) can improve quality of life for people with severe depression. You’ll continue your usual care while also receiving this therapy, and the researchers will track how your mood and daily life change over time.
LimogesAges 20–60 - NCT06323785Recruiting
Whole-body hyperthermia for depression
This trial tests whether safely raising your body temperature (whole-body hyperthermia) can help relieve depression. It's for people with moderate to severe major depression who are not currently taking antidepressants.
ZurichAges 18–65 - NCT06443216Recruiting
Sleep modulation to treat depression
This study tests whether adjusting sleep patterns can help treat depression. It uses gentle brain stimulation (tDCS or TMS) and sound to study sleep's effect on mood.
GenevaAges 30–60 - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT06976840Recruiting
Rapid antidepressant effects of new brain stimulation methods
This trial tests whether two types of non-invasive brain stimulation can quickly improve depression symptoms. It may be an option for adults with major depression who are not currently taking psychiatric medication.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07003997RecruitingPhase 2
JAK inhibitor for depression with inflammation
This trial tests a JAK inhibitor (a type of anti-inflammatory drug) for depression that is linked to inflammation. If you have depression or bipolar depression and a high CRP level (a marker of inflammation), you may be eligible.
Atlanta, GeorgiaAges 25–55 - NCT07033780RecruitingPhase 1
Brain stimulation study for depression treatment
This trial tests a new type of brain stimulation called theta-burst stimulation to see if it helps treat depression. It is for people aged 18-50 who are currently experiencing a major depressive episode and are on a stable antidepressant regimen.
Toronto, OntarioAges 18–50 - NCT07100951Recruiting
Comparing two couples therapies for relationship distress
This study compares two types of couples therapy to see which is better at reducing relationship distress. If you and your partner are feeling unhappy or struggling, and either of you also has symptoms of depression or anxiety, this trial may offer free professional help.
IstanbulAges 24–65 - NCT07212465Recruiting
Brain stimulation for depression in older adults
This study tests a new, faster brain stimulation method for depression in adults aged 60-85 who haven't improved with medication. The treatment targets a part of the brain linked to mood and may offer relief for those who have not found other treatments effective.
Toronto, OntarioAges 60–85 - NCT07221409Recruiting
Virtual reality to help cancer patients feel better during treatment
This trial tests whether using virtual reality can help reduce stress, anxiety, and other emotional symptoms in people being treated for cancer. Patients undergoing chemotherapy, bone marrow transplant, or CAR-T therapy may be eligible.
Jacksonville, FloridaAges 18–90 - NCT07242105Recruiting
Improving brain activity in depression
This study tests if a type of brain stimulation (TMS) can improve brain function in people with depression. It also includes a small group of epilepsy patients who are already having brain monitoring. The goal is to find new ways to treat depression by targeting specific brain areas.
Iowa City, CaliforniaAges 18–65 - NCT07349706Recruiting
Breathing exercise for dementia risk reduction
This trial tests a simple breathing exercise done for about 5–10 minutes each day for 8 weeks. It aims to see if this exercise can reduce your risk of dementia. If you are between 60 and 80 years old and have at least one risk factor for dementia, this study may be a fit for you.
Tallahassee, FloridaAges 60–80 - NCT07383467Recruiting
Single session help for teens with anxiety or depression
This trial offers a one-time digital self-help program for Hong Kong teens aged 12 to 17 who feel anxious or down. It aims to see if a single session can make a difference.
Hong KongAges 12–17 - NCT00025935Recruiting
Brain Function Studies in Youth With Mood and Attention Disorders
This research study examines how the brains of children and teenagers with mood problems (like persistent irritability or depression) or attention difficulties work differently. Researchers use brain scans and tasks to understand these conditions better and track changes as young people grow up.
Bethesda, MarylandAges 7–60 - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07507370Recruiting
CARED: A fast new treatment plan for depression
This study tests a quick treatment approach for adults with major depression who have not gotten enough help from at least one antidepressant. It aims to see if a new rapid method can improve mood safely.
Chapel Hill, North CarolinaAges 18–70 - NCT07510880Recruiting
Home brain stimulation for major depression
This trial tests a home-based brain stimulation device (tDCS) to treat depression. You would use a headset daily for a few weeks, and the study team will check in to make sure it's working safely and effectively.
L'Hospitalet de Llobregat, BarcelonaAges 18–65 - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 409 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.