Clinical trials
Bipolar clinical trials
Below are recruiting bipolar clinical trials, each written for real people, not researchers. We’re tracking 241 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04184375Recruiting
Memory training for older adults with bipolar disorder
This study tests whether structured memory and thinking exercises (cognitive stimulation) help older adults with bipolar disorder who have mild to moderate thinking and memory problems. You may be offered guided sessions designed to improve everyday thinking skills while checking safety and fit for the program.
La RochelleAges 65 years+ - NCT07288320RecruitingPhase 2
Testing NBI-1117568 for bipolar I mania
This trial tests an experimental drug called NBI-1117568 for people with bipolar I disorder who are currently having a manic or mixed episode. The goal is to see if the drug helps calm mania symptoms and is safe.
Little Rock, ArkansasAges 18–65 - NCT07263191Recruiting
Olanzapine study for bipolar disorder
This study looks at how well patients with bipolar disorder do while taking the medication olanzapine. You will continue your regular treatment, and answer questions about your experience.
SeongnamAges 19 years+ - NCT07266545RecruitingPhase 4
RNA markers for antidepressant response in depression
This study looks at how RNA might help predict which antidepressant works best for you. It tests two medications: vortioxetine and cariprazine, in people with major depressive disorder or bipolar depression.
Rochester, MinnesotaAges 18–65 - NCT07221864Recruiting
Emotions and brain activity in bipolar disorder
This study uses brain scans to understand emotions in bipolar disorder. It compares people with bipolar who are currently depressed or in a mixed state to healthy volunteers, and involves up to two visits to the research center.
Tulsa, OklahomaAges 18–65 - NCT06914284Recruiting
Apathy and thinking changes in older adults with bipolar disorder
This study looks at whether apathy and certain brain markers can help predict memory and thinking problems in people over 70 with bipolar disorder. If you are 70-85, have bipolar disorder, and are currently stable (no recent mood episodes), you may be able to join.
Rennes, Ile Et VilaineAges 70–85 - NCT07213492Recruiting
Support program for young adults with bipolar disorder
This study tests a program to help young adults with a recent bipolar diagnosis move from hospital back to their community. You would get education sessions and support from peers to make the transition smoother.
Hamilton, OntarioAges 18–35 - NCT06022913Recruiting
Behavioral activation therapy for bipolar depression
This trial tests a therapy called behavioral activation to help people with bipolar depression feel better. The therapy focuses on increasing positive activities and routines to improve mood.
ReykjavikAges 18 years+ - NCT07194278Recruiting
Blue-blocking glasses for bipolar mania
This study tests whether special blue-blocking glasses can help reduce manic symptoms in people with bipolar disorder who are currently in a manic episode. You would wear the glasses for several hours a day, and the study would check if your symptoms improve.
Paris, FranceAges 18 years+ - NCT05867849RecruitingPhase 3
Cannabidiol treatment for bipolar depression symptoms
This trial tests whether cannabidiol (CBD) can reduce symptoms of bipolar depression. You may be eligible if you have bipolar I or II and a current depressive episode while staying on approved mood-stabilizing or antipsychotic medication.
Vancouver, British ColumbiaAges 19–70 - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT07140913RecruitingPhase 3
Testing KarXT for bipolar I mania with mood stabilizers
This study tests whether adding KarXT to lithium, valproate, or lamotrigine helps calm manic episodes in people with bipolar I disorder. It aims to see if the combination is safe and works better than the mood stabilizer alone.
Bentonville, ArkansasAges 18–65 - NCT07121894Recruiting
Ketogenic diet for bipolar depression
This study tests whether a strict low-carbohydrate, high-fat (ketogenic) diet can improve symptoms of depression in people with bipolar disorder. Participants will receive dietary guidance and support to help them follow the diet for several weeks.
Rochester, MinnesotaAges 18–50 - NCT07108257Recruiting
Focused ultrasound for bipolar depression
This trial uses sound waves guided by MRI to target a small brain area. It aims to help people with bipolar depression that hasn't improved with standard treatments.
Toronto, OntarioAges 18–65 - NCT07071532RecruitingPhase 1
Study of ABBV-932 with itraconazole for bipolar disorder
This study tests an investigational drug called ABBV-932 in people with bipolar disorder. It looks at how the drug moves through the body when taken with another medication (itraconazole) and checks for any side effects.
Los Alamitos, CaliforniaAges 18–65 - NCT06983834Recruiting
Mindfulness for caregivers of people with bipolar disorder
This study tests a mindfulness program for caregivers of people with bipolar disorder. It aims to help you feel less stressed, improve your quality of life, and build resilience.
AfyonkarahisarAges 18 years+ - NCT06088732RecruitingPhase 1/Phase 2
Exercise and ibuprofen for bipolar depression
This study tests whether acute exercise and ibuprofen can improve symptoms of bipolar depression by studying their effects on the immune system and brain circuits. It may help if you are currently in a depressive episode and can do moderate physical activity.
Tulsa, OklahomaAges 18–55 - NCT07031661Recruiting
Bipolar disorder risk study for teens and children
This study follows children and teens who may be at higher risk for bipolar disorder to develop a prediction model. It includes three groups: those with a parent who has bipolar disorder, those with atypical depression, and healthy volunteers.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT07020364Recruiting
Study of a single tool for prostate surgery using laser or bipolar energy
This study is testing a new way to perform prostate surgery using a single tool that can use either laser or bipolar energy. It aims to see if this approach is safe and effective for men with a large prostate (40 cc or more) who need surgery to help with urination problems.
Shibīn al Kawm, MenoufiaAges 50 years+ - NCT07021508Recruiting
Testing a new brain stimulation for bipolar depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can safely and effectively improve symptoms of bipolar depression. It may be an option for people who are not taking medication or who are willing to stop their current medication for a short time.
Hangzhou, ZhejiangAges 18–45 - NCT06986460RecruitingPhase 3
Low-frequency TMS for bipolar depression
This study tests whether low-frequency TMS (a gentle magnetic stimulation to a specific part of the brain) can help treat depression in people with bipolar disorder who did not get enough benefit from a previous study. You must be on a mood stabilizer and not taking certain anticonvulsant medications.
Toronto, OntarioAges 18 years+ - NCT06943573RecruitingPhase 2
Psilocybin therapy for bipolar ii depression
This study tests whether a psychedelic drug called psilocybin (the active ingredient in 'magic' mushrooms), combined with therapy, can help relieve depression in people with bipolar II disorder who haven't gotten better with other treatments. You'll receive the drug in a supervised setting and attend follow-up visits to see how it affects your mood.
Vancouver, British ColumbiaAges 19–65 - NCT06951711RecruitingPhase 3
KarXT for mania in bipolar I disorder
This study tests a new medication called KarXT to see if it helps calm manic episodes in people with bipolar I disorder. You would need to be in the hospital for a manic episode and stop other psychiatric medications temporarily.
Little Rock, ArkansasAges 18–65 - NCT06951698RecruitingPhase 3
Testing KarXT for bipolar I mania
This trial tests a new medicine, KarXT, to see if it can safely treat manic episodes in people with bipolar I disorder. It is for patients who are currently hospitalized for a manic episode that started within the last 3 weeks.
Bentonville, ArkansasAges 18–65
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Common questions
- Are there clinical trials for bipolar?
- Yes. Clin2 currently lists 241 recruiting bipolar studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.