Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05907317RecruitingPhase 3
Protecting the brains of very young newborns on breathing machines
This Phase 3 study tests ways to protect brain health in newborns who are very premature or recently born and need a breathing machine through a tube. It may help reduce the risk of brain injury while they receive intensive care.
MadridAges birth–4 weeks - NCT05907343Recruiting
Closed-loop brain stimulation for memory changes
This study tests a type of brain stimulation that adjusts based on your brain signals to see if it can help with cognitive decline or mild memory problems. You may be able to join if you are cognitively normal, or if you have mild cognitive impairment (MCI), and your brain imaging and stimulation setup is possible.
Austin, TexasAges 18–90 - NCT05911230Recruiting
MRI test to tell tumor return from temporary treatment effects
This study uses an advanced MRI scan to help doctors tell the difference between true tumor regrowth and “pseudoprogression,” which is a temporary treatment-related change that can look like progression. If it works, it may guide the safest next steps, including whether surgery is helpful.
BaselAges 18 years+ - NCT05916417Recruiting
Personalized TMS dosing for PTSD using brain monitoring
This study tests a “personalized dosing” approach for transcranial magnetic stimulation (TMS) in adults with PTSD. It aims to see whether using brain measurements to guide the TMS settings can improve treatment while keeping participants safe.
Tallahassee, FloridaAges 18–70 - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT05926336RecruitingPhase 4
Different anesthesia drugs during cancer surgery
This trial compares two types of anesthesia medicines to see how they may affect outcomes after surgery for certain primary cancers. You may be considered if you’re having planned (elective) surgery under general anesthesia and meet the safety and health criteria.
Kaohsiung CityAges 20–80 - NCT05929729RecruitingPhase 4
Brain study in women with iron deficiency anemia
This is a study that looks at how iron deficiency anemia may affect the brain, and it also checks whether giving iron through an IV is safe and helpful for some participants. You may be in an observation-only group or an iron-treatment group, depending on study testing.
Duarte, CaliforniaAges 16–60 - NCT05931562Recruiting
How diet may change gut bacteria and brain signals
This study looks at how changing your diet affects the gut bacteria and how that may influence brain-related signals. It may help researchers understand whether diet could support overall brain and gut health.
CorkAges 18–50 - NCT05934188Recruiting
Study how gut signals relate to brain aging and diseases
This study looks at how the gut may influence the brain in normal aging and conditions like Alzheimer’s, Parkinson’s, and multiple sclerosis. It may help researchers understand new ways to measure or treat these brain changes over time.
Venice-Lido, VeniceAges 20–90 - NCT05936619Recruiting
Brain-computer device for communication in people with paralysis
This trial tests a “brain-computer interface” that aims to help people with paralysis communicate. It involves surgery to place a device and uses frequent follow-ups, including daily help from a caregiver to watch the surgical area and behavior.
Dallas, TexasAges 18–65 - NCT05943756Recruiting
Well-being program for adults living with moderate to severe brain injury
This trial tests whether a well-being program can improve quality of life in adults with moderate to severe traumatic brain injury (TBI) more than a year after the injury. If you meet the language and medical-history requirements, you may be invited to join and complete program sessions and screening.
East Hanover, New JerseyAges 18 years+ - NCT05947149Recruiting
Quality-of-life study in head and neck cancer after hadrontherapy
This study asks people with certain head and neck cancers (or long-term survivors) about how hadrontherapy affected their quality of life. It may help doctors understand long-term wellbeing and care needs after treatment.
Pavia, PvAges 18 years+ - NCT05956821RecruitingPhase 1/Phase 2
Study drug for young people with recurring brain glioma
This Phase 1/2 trial tests a study treatment for children and young adults under 22 whose brain glioma has come back or isn’t responding to prior treatment. It’s designed to see whether the treatment is safe and effective for shrinking tumors in this situation.
Miami, FloridaAges 1–21 - NCT05961111RecruitingEarly Phase 1
Oncolytic virus injection for advanced solid tumors
This early-phase trial tests an injection of a virus designed to attack cancer cells in people with advanced solid tumors. It is meant for situations where standard treatments have not worked (or you can’t/won’t take them) and when doctors can directly deliver the treatment to a tumor spot.
Linyi, ShandongAges 18–75 - NCT05961748Recruiting
Brain and heart illness registry for adults in China
This study is a registry that collects health information from adults who have certain new heart and/or brain conditions. It may help researchers understand how these problems occur together and improve future care planning.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05964764Recruiting
Check which head-injury guidelines work for children
This study tests and confirms Swedish/Norwegian guidelines for treating minor to moderate head injuries in children. It may help doctors decide the safest next steps after an injury, especially for whether and when to use scans and observation.
HaukelandAges Up to 17 years - NCT05968053Recruiting
Testing microplastics detection in neurosurgery patients
This study checks whether microplastics and nanoplastics can be detected in people undergoing neurosurgery. If it works, it could help doctors better understand possible material exposures around brain and nerve procedures.
Beijing, Beijing MunicipalityAges 18–80 - NCT05968703Recruiting
Deep brain stimulation study for mild memory trouble in Parkinson’s
This trial looks at a specific type of deep brain stimulation (DBS) to see if it can help people with Parkinson’s who have mild cognitive problems (mild memory/thinking changes). You may also be asked to temporarily stop Parkinson’s medications around research visits to measure effects more clearly.
Stanford, CaliforniaAges 21–80 - NCT05968976Recruiting
DBS surgery guided while awake versus asleep for essential tremor
This study compares two ways of doing a deep brain stimulation (DBS) procedure for people with essential tremor: using guidance while you are awake versus while you are asleep. It aims to find which approach is safer and works better for controlling disabling tremor.
Amsterdam, North HollandAges 18 years+ - NCT05981755Recruiting
Breathing rescue to prevent SUDEP in epilepsy
This trial tests a breathing rescue device to prevent SUDEP (sudden unexpected death in epilepsy) in people with hard-to-control focal epilepsy who are staying in the hospital for invasive brain monitoring.
Houston, TexasAges 18 years+ - NCT05985486Recruiting
Lifestyle change for brain health in Down syndrome
This study looks at how a healthy lifestyle program can improve brain health in adults with Down syndrome who are overweight or obese. You will attend a medical center three times over a year for tests, and you'll need a caregiver to support you.
Kansas City, KansasAges 18–64 - NCT05986643Recruiting
Brain training game to improve balance in Parkinson's
This trial tests a brain-training game designed to improve balance in people with Parkinson's disease. You may be eligible if you have mild to moderate Parkinson's, have had a fall and freezing episodes in the past year, and are not very active.
LeicesterAges Any age - NCT05989646Recruiting
Brain activity study in children with overactive bladder
This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. It uses MRI scans to understand how the brain controls the bladder, which could lead to better treatments.
AalborgAges 6–14 - NCT05992402Recruiting
Brain training program for epilepsy surgery readiness
This study tests a cognitive training program called ReBOOT for adults with epilepsy who are eligible for surgery. The program is done online and aims to improve brain function before surgery.
Cleveland, OhioAges 18–60
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.