Clinical trials
Chronic Obstructive Pulmonary Disease Severe clinical trials
Below are recruiting chronic obstructive pulmonary disease severe clinical trials, each written for real people, not researchers. We’re tracking 212 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06390345Recruiting
Telehealth lifestyle and exercise for COPD and sleep apnea
This study tests a telehealth program that combines lifestyle coaching and exercise to help people with both COPD and sleep apnea improve their breathing and daily function. It may be a good fit if you are overweight, have a history of smoking, and feel short of breath during light activity.
Boise, IdahoAges 18 years+ - NCT06377410Recruiting
Ivy extract vs NAC for COPD: Which works better?
This study compares two treatments – a dry powder ivy extract and a common mucus-thinning medicine called NAC – to see which is safer and more effective for people with stable COPD. If you have COPD and are over 40, this trial could help find a better option to manage your symptoms.
Cheras, Kuala LumpurAges 40 years+ - NCT06376994RecruitingPhase 3
Clean air study for COPD
This study tests if using air cleaners at home improves lung health in people with COPD. If you qualify, you may get an air cleaner for your home and be followed for 12 months.
Birmingham, AlabamaAges 40 years+ - NCT06283966RecruitingPhase 3
Triple inhaler for COPD with heart risk
This study tests a triple-combination inhaler (budesonide, glycopyrronium, and formoterol) to see if it can help protect the heart and lungs in people with COPD who also have heart problems or high risk for them.
Athens, AlabamaAges 40–80 - NCT06188065Recruiting
Eosinopenia and Recovery in Severe COPD Exacerbation
This study is looking at people admitted to the hospital for a severe COPD flare-up. It checks if a low level of eosinophils (a type of white blood cell) in the blood is linked to how quickly you recover from the flare-up.
North ShieldsAges 35 years+ - NCT01177618Recruiting
Study of early-onset severe COPD in younger adults
This study looks at people who develop COPD (a long-term lung breathing problem) at a younger age and have severe airflow limitation. It may help researchers better understand COPD in early-onset patients and find ways to improve care for this group.
Boston, MassachusettsAges Any age - NCT06068647Recruiting
Ultrasound and breathing tests for lung disease patients
This study uses ultrasound and sensors to monitor lung health in people with certain lung conditions, including those that cause scarring or breathing problems. It aims to find better ways to track lung disease, which could help manage your condition more effectively.
RomeAges 18 years+ - NCT06072690Recruiting
COPD and Heart Health Study
This study looks at how COPD affects your breathing and heart health. It is for people who are newly diagnosed with COPD and have a history of smoking.
Kaunas, Kaunas CountyAges 40 years+ - NCT05785026Recruiting
Menthol to reduce breathlessness in COPD and healthy adults
This trial tests whether menthol helps with breathlessness (dyspnea) during exercise. You may be asked to do breathing and exercise tests, and to use menthol under study supervision to see if symptoms improve.
LeuvenAges 18 years+ - NCT05989698Recruiting
Validating a wearable cough monitor (C-mo)
This study tests a wearable device (C-mo) that monitors coughing. It is for people of all ages who are currently coughing and can cooperate with wearing a small sensor on their belly for a short time.
AlfenaAges 2 years+ - NCT05937854RecruitingPhase 2
Tadalafil to help breathing in COPD with pulmonary hypertension
This Phase 2 study tests whether tadalafil can improve breathlessness in people with COPD and pulmonary hypertension (high blood pressure in the lungs). It may help you breathe more easily if your symptoms are driven by this specific lung circulation problem.
Aurora, ColoradoAges 35–89 - NCT05896579Recruiting
Study heart function during rest and exercise in COPD
This study measures how well the right side of your heart works when you are resting and when you exercise, in people with chronic obstructive pulmonary disease (COPD). It may help researchers better understand COPD-related heart strain and guide future care.
Aurora, ColoradoAges 40 years+ - NCT05844462RecruitingPhase 3
Tadalafil for severe lung blood-pressure problems from COPD
This study tests whether tadalafil can improve outcomes for people with severe pulmonary hypertension caused by COPD (chronic lung disease). It compares how you do with tadalafil versus standard care, focusing on breathing symptoms and how well your heart and lungs cope.
Le Kremlin-Bicêtre, FranceAges 18–85 - NCT05572632Recruiting
COPD wellness rehab program for safety-net patients
This trial studies a COPD (chronic lung disease) wellness and rehabilitation program for people who get care through the safety-net health system. It may help improve day-to-day outcomes by supporting safer exercise and better COPD management.
San Francisco, CaliforniaAges 40–90 - NCT05704881Recruiting
Using breath CO2 levels to judge COPD flare severity in ER
This study measures an easy breathing signal called end-tidal carbon dioxide (a CO2 reading from your exhaled breath) to help judge how severe a COPD flare is. It may help doctors decide how closely you need monitoring and treatment during emergency care.
Grenoble, IsèreAges 18 years+ - NCT05237505RecruitingPhase 2
Sleep apnea plus COPD study to check heart and breathing effects
This Phase 2 study looks at the cardiovascular (heart/blood vessel) effects of having both sleep apnea and COPD. It may help doctors better understand who is at risk and how to manage these breathing problems together.
La Jolla, CaliforniaAges 40–79 - NCT05196698Recruiting
Home high-flow oxygen after COPD hospital flare
This study tests whether using a special oxygen device at home helps prevent another acute COPD flare after you’ve been hospitalized. It’s mainly for people with severe breathing problems who may need oxygen support long-term.
RouenAges 18–85 - NCT05061368RecruitingPhase 2
Sildenafil by mouth to improve breathing in COPD
This Phase 2 trial tests whether sildenafil tablets can improve exercise ability, shortness of breath, and heart-lung function in people with COPD. It also compares against people without COPD to better understand how sildenafil affects breathing tests.
Edmonton, AlbertaAges 40–80 - NCT04849806Recruiting
Testing whether heart nerve signals predict COPD symptoms
This study looks at “sympathetic nerve activity” (signals from the nervous system that affect the heart) in adults with chronic obstructive pulmonary disease (COPD). The goal is to see whether these measurements can help predict what happens to people with COPD.
AachenAges 18 years+ - NCT04339270RecruitingPhase 4
Testing azithromycin in chronic lung disease with frequent flare-ups
This Phase 4 study tests whether a long course of azithromycin can reduce flare-ups in people with chronic obstructive pulmonary disease (COPD) who have had recent exacerbations. It also looks at mucus properties and how flare-ups happen.
BordeauxAges 40–85 - NCT04179981Recruiting
CPAP treatment effects in older COPD and sleep apnea patients
This study looks at whether using positive airway pressure (often called CPAP) improves health outcomes in older adults who have both COPD and obstructive sleep apnea. It may help find ways to reduce symptoms and complications from “overlap” breathing problems.
Detroit, MichiganAges 60 years+ - NCT03044847Enrolling by invitation
Long-term study of COPD in adults in China
This study follows people with COPD (chronic lung disease) over many years to better understand the condition. It may help doctors learn what factors predict worsening over time.
Beijing, Beijing MunicipalityAges 40–75 - NCT02966665RecruitingPhase 1
Testing blood vessel function in people of different health conditions
This early study measures how well your blood vessels work using tests that may include MRI. It compares healthy people with people who have conditions like COPD, pulmonary arterial hypertension, heart failure, or high blood pressure, to better understand “vascular function” in health and disease.
Salt Lake City, UtahAges 18 years+ - NCT04911491Recruiting
Breathing muscle training for people with kidney disease
This study tests whether training your breathing muscles can improve health in people with chronic kidney disease (stage 3–4). It may help how your body handles daily activity and circulation-related measurements, compared with usual care.
Aurora, ColoradoAges 50 years+
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Common questions
- Are there clinical trials for chronic obstructive pulmonary disease severe?
- Yes. Clin2 currently lists 212 recruiting chronic obstructive pulmonary disease severe studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic obstructive pulmonary disease severe trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic obstructive pulmonary disease severe trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.